David J Snyder Selected Research

Chimeric Antigen Receptors

1/2019	Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
1/2018	Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.
2/2014	EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.

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David J Snyder Research Topics

Disease

5	Neoplasms (Cancer) 01/2022 - 02/2014
3	Glioma (Gliomas) 01/2020 - 02/2014
2	Melanoma (Melanoma, Malignant) 01/2022 - 09/2011
2	Lymphopenia (Lymphocytopenia) 01/2018 - 09/2011
2	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 09/2011
1	Experimental Melanoma 01/2019
1	Exanthema (Rash) 09/2015
1	Serum Sickness 09/2015
1	Venous Thromboembolism 09/2015
1	Fever (Fevers) 09/2015
1	Brain Neoplasms (Brain Tumor) 02/2014
1	Hemorrhage 02/2012
1	Thrombosis (Thrombus) 02/2012
1	Carcinogenesis 09/2011

Drug/Important Bio-Agent (IBA)

4	epidermal growth factor receptor VIIIIBA 01/2020 - 02/2014
3	Chimeric Antigen ReceptorsIBA 01/2019 - 02/2014
2	VaccinesIBA 01/2022 - 09/2011
2	AntigensIBA 01/2022 - 02/2014
2	ErbB Receptors (EGF Receptor)IBA 01/2020 - 02/2014
2	Temozolomide (Temodar)FDA LinkGeneric 01/2018 - 09/2011
1	Therapeutic UsesIBA 01/2022
1	AntibodiesIBA 01/2022
1	EpitopesIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	Cancer VaccinesIBA 01/2022
1	Subunit VaccinesIBA 01/2022
1	Immunoglobulin FragmentsIBA 01/2020
1	Interleukin-2 (IL2)IBA 01/2019
1	Single-Chain AntibodiesIBA 01/2018
1	Complement System Proteins (Complement)IBA 09/2015
1	RivaroxabanIBA 09/2015
1	Neoplasm Antigens (Tumor Antigens)IBA 02/2014
1	von Willebrand FactorIBA 02/2012
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 02/2012
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 02/2012
1	Nucleotide AptamersIBA 02/2012
1	Clopidogrel (Plavix)FDA Link 02/2012
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 09/2011
1	Monoclonal AntibodiesIBA 09/2011

Therapy/Procedure

3	Immunotherapy 01/2018 - 09/2011
2	Therapeutics 01/2018 - 02/2014
1	Knee Replacement Arthroplasty (Total Knee Replacement) 09/2015