Scott B Snapper Selected Research

Interleukin-10 (Interleukin 10)

1/2023	Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications.
10/2022	CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.
9/2021	Restored Macrophage Function Ameliorates Disease Pathophysiology in a Mouse Model for IL10 Receptor-deficient Very Early Onset Inflammatory Bowel Disease.
1/2020	Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.
11/2017	Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.
12/2016	Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.
1/2016	Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report.
11/2014	The diagnostic approach to monogenic very early onset inflammatory bowel disease.
5/2014	Protective mucosal immunity mediated by epithelial CD1d and IL-10.
4/2014	Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.

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Scott B Snapper Research Topics

Disease

30	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2024 - 06/2004
24	Colitis 05/2024 - 03/2003
23	Inflammation (Inflammations) 05/2024 - 06/2004
8	Crohn Disease (Crohn's Disease) 02/2024 - 01/2012
7	Wiskott-Aldrich Syndrome 10/2016 - 03/2003
4	Neutropenia 11/2023 - 06/2010
4	Infections 01/2020 - 12/2008
3	Ulcerative Colitis 02/2024 - 07/2019
3	Enterocolitis 04/2014 - 11/2009
2	Virus Diseases (Viral Diseases) 01/2020 - 12/2003
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019 - 01/2017
2	Diarrhea 01/2019 - 01/2019
2	Cicatrix (Scar) 10/2011 - 01/2004
1	Disease Progression 05/2024
1	Glycogen Storage Disease (Glycogenosis) 11/2023
1	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2023
1	Compression Fractures (Compression Fracture) 02/2023
1	Back Pain (Backache) 02/2023
1	Schistosomiasis japonica 01/2023
1	Growth Disorders 09/2022
1	Rare Diseases (Rare Disease) 06/2022
1	Sensorineural Hearing Loss 11/2021
1	Hereditary alpha-tryptasemia syndrome 01/2021
1	Intestinal Atresia 10/2020
1	Lung Injury 01/2020
1	Failure to Thrive 01/2019
1	2 X-Linked Lymphoproliferative Syndrome 01/2019
1	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2018
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Gastroesophageal Reflux (GERD) 01/2018
1	Hypersensitivity (Allergy) 01/2018
1	Eosinophilic Esophagitis 01/2018
1	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 01/2017
1	Thrombosis (Thrombus) 01/2017

Drug/Important Bio-Agent (IBA)

14	Wiskott-Aldrich Syndrome ProteinIBA 11/2021 - 12/2003
13	Proteins (Proteins, Gene)FDA Link 05/2024 - 07/2003
13	Interleukin-10 (Interleukin 10)IBA 01/2023 - 09/2012
8	Interleukin-10 ReceptorsIBA 01/2023 - 11/2009
5	CytokinesIBA 01/2023 - 10/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2023 - 12/2016
3	RNA (Ribonucleic Acid)IBA 06/2022 - 01/2017
3	InterleukinsIBA 01/2018 - 10/2009
3	Interferon-gamma (Interferon, gamma)IBA 12/2016 - 10/2007
3	AutoantibodiesIBA 06/2015 - 06/2004
2	AntibodiesIBA 02/2024 - 01/2021
2	Infliximab (Remicade)FDA Link 02/2024 - 01/2022
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2023 - 01/2018
2	GlucocorticoidsIBA 02/2023 - 01/2022
2	Interleukin-2 (IL2)IBA 01/2023 - 01/2019
2	InterferonsIBA 01/2020 - 01/2018
2	Interleukin-12 (IL 12)IBA 01/2018 - 12/2003
2	Immunoglobulin E (IgE)IBA 01/2018 - 10/2016
2	Messenger RNA (mRNA)IBA 01/2018 - 01/2017
2	Clodronic Acid (Clodronate)IBA 01/2017 - 10/2005
2	Oxidoreductases (Dehydrogenase)IBA 09/2015 - 09/2014
2	AntigensIBA 05/2014 - 11/2008
1	Bile Acids and Salts (Bile Acids)IBA 05/2024
1	Biomarkers (Surrogate Marker)IBA 05/2024
1	Interleukin-18 (Interleukin 18)IBA 05/2024
1	SphingolipidsIBA 05/2024
1	Interleukin-22 (IL-22)IBA 05/2024
1	Immunologic Factors (Immunomodulators)IBA 02/2024
1	empagliflozinIBA 11/2023
1	1,5-anhydroglucitol-6-phosphateIBA 11/2023
1	Diphosphonates (Bisphosphonates)IBA 02/2023
1	Proton Pump InhibitorsIBA 02/2023
1	HerbicidesIBA 11/2022
1	pronamide (Kerb)IBA 11/2022
1	Cholecalciferol (Vitamin D3)FDA Link 01/2022
1	Qa-SNARE Proteins (Syntaxin)IBA 11/2021
1	Carrier Proteins (Binding Protein)IBA 11/2021
1	Lipocalin-2IBA 11/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Tight Junction ProteinsIBA 01/2021
1	SuspensionsIBA 01/2021
1	Volatile Fatty AcidsIBA 01/2021
1	Tryptases (Tryptase)IBA 01/2021
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2020
1	Leflunomide (Arava)FDA LinkGeneric 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2019
1	Monoclonal AntibodiesIBA 07/2019
1	Muromonab-CD3 (Muromonab CD3)FDA Link 07/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	X-Linked Inhibitor of Apoptosis ProteinIBA 01/2019
1	EnzymesIBA 01/2019
1	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Dextrans (Dextran)FDA Link 01/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2017
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 12/2016
1	AcidsIBA 10/2016
1	Granzymes (Granzyme)IBA 10/2016
1	AllergensIBA 10/2016

Therapy/Procedure

3	Therapeutics 01/2017 - 02/2011
2	Hematopoietic Stem Cell Transplantation 10/2023 - 01/2019
1	Precision Medicine 12/2023
1	Gastrostomy 09/2022
1	Total Parenteral Nutrition 09/2022