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Clyde A Smith Selected Research

Carbapenems (Carbapenem Antibiotics)

3/2024Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase.
12/2023The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases.
1/2022C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.
10/2019Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 β-Lactamase.
8/2017The role of conserved surface hydrophobic residues in the carbapenemase activity of the class D β-lactamases.
1/2015Kinetic and structural requirements for carbapenemase activity in GES-type β-lactamases.
1/2014Crystal structure of carbapenemase OXA-58 from Acinetobacter baumannii.
9/2013Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.
12/2012Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases.

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Clyde A Smith Research Topics

Disease

9Infections
03/2024 - 12/2012
3Neoplasms (Cancer)
01/2021 - 11/2008
2Asthma (Bronchial Asthma)
01/2021 - 07/2015
2Reperfusion Injury
01/2021 - 07/2015
2Bacterial Infections (Bacterial Infection)
03/2014 - 01/2014
2Tuberculosis (Tuberculoses)
07/2008 - 04/2005
1Gastroesophageal Reflux (GERD)
01/2022
1Acinetobacter Infections
09/2013
1Hypertension (High Blood Pressure)
10/2009
1Cardiovascular Diseases (Cardiovascular Disease)
10/2009
1Heart Failure
10/2009
1Hypersensitivity (Allergy)
02/2003
1Leukemia
02/2003

Drug/Important Bio-Agent (IBA)

9Carbapenems (Carbapenem Antibiotics)IBA
03/2024 - 12/2012
4EnzymesIBA
11/2021 - 02/2003
3Anti-Bacterial Agents (Antibiotics)IBA
11/2021 - 03/2014
1carbapenemaseIBA
01/2022
1Proton Pump InhibitorsIBA
01/2022
1gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
01/2021
1Cysteine (L-Cysteine)FDA Link
07/2015
1LactamsIBA
03/2014
1Captopril (Capoten)FDA LinkGeneric
10/2009
1Proteins (Proteins, Gene)FDA Link
11/2008
1Adenosine Diphosphate (ADP)IBA
07/2008
15'-adenylyl (beta,gamma-methylene)diphosphonateIBA
07/2008
1AcetyltransferasesIBA
04/2005
1SiderophoresIBA
04/2005
1AminoglycosidesIBA
04/2005
1folylpolyglutamate synthetaseIBA
02/2003
1Folic Acid (Vitamin M)FDA LinkGeneric
02/2003
1Folic Acid AntagonistsIBA
02/2003

Therapy/Procedure

1Therapeutics
12/2012