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F M Sirotnak Selected Research

Probenecid (Benemid)

10/2001Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.
9/2000Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo.

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F M Sirotnak Research Topics

Disease

16Neoplasms (Cancer)
11/2011 - 01/2000
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2011 - 09/2000
4Mesothelioma
04/2007 - 10/2001
3Mucositis
11/2011 - 09/2000
3Stomatitis
05/2007 - 06/2003
2Prostatic Neoplasms (Prostate Cancer)
11/2004 - 01/2000
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
11/2011
1Peripheral Nervous System Diseases (PNS Diseases)
05/2007
1Asthenia
05/2007
1Malignant Mesothelioma
04/2007
1Lymphoma (Lymphomas)
06/2003
1Breast Neoplasms (Breast Cancer)
06/2003
1Colonic Neoplasms (Colon Cancer)
12/2001
1Colorectal Neoplasms (Colorectal Cancer)
12/2001
1Leukopenia
03/2001
1Renal Insufficiency (Renal Failure)
03/2001
1Ascites
09/2000
1Hepatocellular Carcinoma (Hepatoma)
07/2000
1Tics (Tic)
01/2000

Drug/Important Bio-Agent (IBA)

510-propargyl-10-deazaaminopterinFDA Link
11/2011 - 09/2000
5Folic Acid AntagonistsIBA
11/2011 - 09/2000
5Folic Acid (Vitamin M)FDA LinkGeneric
06/2003 - 09/2000
4Methotrexate (Mexate)FDA LinkGeneric
06/2003 - 09/2000
3Paclitaxel (Taxol)FDA LinkGeneric
05/2007 - 01/2000
3Gefitinib (Iressa)FDA Link
03/2007 - 12/2000
3Cytotoxins (Cytolysins)IBA
09/2003 - 03/2000
3edatrexateIBA
10/2001 - 12/2000
2VitaminsIBA
11/2011 - 05/2007
2Docetaxel (Taxotere)FDA Link
05/2007 - 03/2007
2ErbB Receptors (EGF Receptor)IBA
09/2003 - 12/2000
210-deazaaminopterinIBA
10/2001 - 09/2000
2Adenosine Triphosphatases (ATPase)IBA
10/2001 - 09/2000
2Probenecid (Benemid)FDA LinkGeneric
10/2001 - 09/2000
2Multidrug Resistance-Associated ProteinsIBA
10/2001 - 09/2000
2Cisplatin (Platino)FDA LinkGeneric
03/2001 - 12/2000
2Multidrug Resistance-Associated Protein 2IBA
09/2000 - 07/2000
1Taxoids (Taxanes)IBA
03/2007
1AndrogensIBA
11/2004
1Testosterone (Sustanon)FDA Link
11/2004
1Tyrosine Kinase InhibitorsIBA
09/2003
1HomocysteineIBA
06/2003
1Trans-Activators (Trans-Acting Factor)IBA
05/2002
1Folate Receptor 1IBA
05/2002
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
05/2002
1Reduced Folate Carrier ProteinIBA
05/2002
1Topoisomerase I InhibitorsIBA
12/2001
1Irinotecan (Camptosar)FDA LinkGeneric
12/2001
1alvocidib (flavopiridol)IBA
12/2001
1A-Form DNA (A-DNA)IBA
12/2001
1Platinum Compounds (Compounds, Platinum)IBA
10/2001
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2000
1Monoclonal AntibodiesIBA
12/2000
1multidrug resistance-associated protein 1IBA
09/2000
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
09/2000
1Proteins (Proteins, Gene)FDA Link
09/2000
1Uricosuric AgentsIBA
09/2000
1Messenger RNA (mRNA)IBA
07/2000
1Vinca AlkaloidsIBA
03/2000
1L 744832IBA
01/2000
1PeptidomimeticsIBA
01/2000

Therapy/Procedure

3Therapeutics
06/2003 - 01/2000
2Drug Tapering
12/2000 - 09/2000
1Transplantation
11/2004
1Radiotherapy
09/2003
1Drug Therapy (Chemotherapy)
09/2000
1Withholding Treatment
01/2000