Tsuyoshi Shuto Selected Research

Inflammation (Inflammations)

7/2022	A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells.
1/2021	Metformin ameliorates the severity of experimental Alport syndrome.
6/2019	Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases.
10/2018	Mild electrical stimulation with heat shock reduces inflammatory symptoms in the imiquimod-induced psoriasis mouse model.

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Tsuyoshi Shuto Research Topics

Disease

13	Neoplasms (Cancer) 01/2021 - 11/2002
11	Hereditary Nephritis (Alport Syndrome) 04/2024 - 01/2012
11	Cystic Fibrosis (Mucoviscidosis) 04/2020 - 08/2002
8	Amyloidosis 09/2023 - 01/2006
6	Proteinuria 01/2022 - 01/2012
5	Chronic Obstructive Pulmonary Disease (COPD) 12/2023 - 05/2002
5	Fibrosis (Cirrhosis) 01/2022 - 01/2017
5	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/2018 - 06/2008
4	Inflammation (Inflammations) 07/2022 - 10/2018
4	Obstructive Lung Diseases (Obstructive Lung Disease) 06/2022 - 12/2016
4	Infections 03/2015 - 11/2002
4	Hyperthermia 06/2008 - 12/2005
3	Emphysema 12/2023 - 06/2019
3	Nephritis 12/2021 - 01/2012
3	Insulin Resistance 02/2013 - 01/2008
2	Kidney Diseases (Kidney Disease) 04/2024 - 12/2017
2	Sclerosis 01/2021 - 12/2017
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 02/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2015 - 07/2010
2	Hyperglycemia 01/2011 - 01/2008
2	Inborn Genetic Diseases (Disease, Hereditary) 07/2010 - 05/2006
2	Carcinoma (Carcinomatosis) 07/2010 - 03/2003
2	Polyneuropathies (Polyneuropathy) 06/2008 - 01/2006
1	Cognitive Dysfunction 03/2024
1	Frailty 03/2024
1	Pneumonia (Pneumonitis) 10/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Fatty Liver 01/2022
1	Chronic Kidney Failure (Chronic Renal Failure) 12/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Ototoxicity 01/2021
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2021
1	Chronic Renal Insufficiency 01/2021
1	Nephrotic Syndrome (Syndrome, Nephrotic) 10/2020
1	Glomerulonephritis 05/2020
1	Disease Progression 05/2020
1	Weight Gain 01/2020
1	Obesity 01/2020
1	Amyloid Plaque 01/2019
1	Transthyretin-Related Hereditary Amyloidosis 01/2019

Drug/Important Bio-Agent (IBA)

11	Prealbumin (Transthyretin)IBA 09/2023 - 01/2006
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
7	Collagen Type IV (Type IV Collagen)IBA 04/2024 - 01/2012
7	Amyloid (Amyloid Fibrils)IBA 01/2023 - 01/2006
4	CreatinineIBA 01/2022 - 01/2017
4	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 04/2011 - 08/2002
3	Blood Proteins (Serum Proteins)IBA 09/2023 - 07/2010
3	MucinsIBA 10/2022 - 11/2002
3	Blood Glucose (Blood Sugar)IBA 06/2022 - 01/2008
3	Messenger RNA (mRNA)IBA 01/2020 - 01/2016
3	CytokinesIBA 12/2017 - 03/2003
3	Transcription Factors (Transcription Factor)IBA 01/2016 - 01/2011
2	Pancreatic Elastase (Elastase)IBA 12/2023 - 06/2019
2	Toll-Like Receptors (Toll-Like Receptor)IBA 07/2022 - 01/2013
2	Metformin (Glucophage)FDA LinkGeneric 06/2022 - 01/2021
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 10/2020
2	CurcuminIBA 03/2019 - 02/2007
2	NitrogenIBA 01/2018 - 01/2017
2	Urea (Carbamide)FDA LinkGeneric 01/2018 - 01/2017
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2018 - 11/2002
2	Proto-Oncogene Proteins c-etsIBA 01/2017 - 11/2002
2	Insulin (Novolin)FDA Link 02/2013 - 01/2008
2	Double-Stranded RNA (RNA, Double Stranded)IBA 04/2012 - 11/2008
2	Toll-Like Receptor 3IBA 04/2012 - 07/2010
2	InterleukinsIBA 01/2012 - 11/2002
2	LigandsIBA 07/2010 - 12/2007
2	Poly I-CIBA 07/2010 - 11/2008
1	ErgothioneineIBA 03/2024
1	Drinking WaterIBA 03/2024
1	Amino Acids FDA Link 03/2024
1	SulfurIBA 03/2024
1	Iodothyronine Deiodinase Type IIIBA 12/2023
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 12/2023
1	NaphthoquinonesIBA 01/2023
1	AMP-Activated Protein KinasesIBA 06/2022
1	Sodium Channels (Sodium Channel)IBA 06/2022
1	Amiloride (Midamor)FDA LinkGeneric 06/2022
1	Epithelial Sodium ChannelsIBA 06/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	bardoxolone methylIBA 01/2022
1	Discoidin Domain Receptor 2IBA 12/2021
1	CholesterolIBA 01/2021
1	Losartan (Cozaar)FDA LinkGeneric 01/2021
1	CollagenIBA 05/2020
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 05/2020
1	MacrolidesIBA 04/2020
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2020
1	Exenatide (Byetta)FDA Link 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 01/2020
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2020
1	gnetin CIBA 01/2020
1	gnemonoside AIBA 01/2020
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2020
1	Sirtuin 1IBA 06/2019
1	pyrvinium (Vankin)FDA Link 01/2019
1	Amyloidogenic ProteinsIBA 01/2019
1	Apomorphine FDA Link 01/2019
1	Cyclic AMP (AMP, Cyclic)IBA 01/2019

Therapy/Procedure

8	Therapeutics 12/2023 - 12/2005
2	Induced Hyperthermia (Thermotherapy) 06/2008 - 12/2005