Jake Shortt Selected Research

Leukemia

1/2022	Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells.
3/2016	The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.
12/2013	An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.

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Jake Shortt Research Topics

Disease

21	Neoplasms (Cancer) 01/2023 - 07/2012
16	Lymphoma (Lymphomas) 03/2024 - 10/2012
8	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 07/2007
6	Hematologic Neoplasms (Hematological Malignancy) 03/2024 - 10/2012
6	B-Cell Lymphoma (Lymphoma, B Cell) 05/2023 - 10/2012
6	Multiple Myeloma 01/2023 - 01/2014
6	Thrombotic Thrombocytopenic Purpura 10/2022 - 01/2013
5	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2023 - 01/2021
5	Infections 05/2023 - 01/2018
3	Thrombocytopenia (Thrombopenia) 10/2023 - 01/2021
3	Leukemia 01/2022 - 12/2013
3	Carcinogenesis 11/2013 - 12/2012
2	Hemorrhage 12/2023 - 10/2023
2	Neutropenia 01/2023 - 01/2021
2	COVID-19 01/2023 - 12/2022
2	Disease Progression 01/2023 - 11/2013
2	Autoimmune Diseases (Autoimmune Disease) 10/2022 - 11/2016
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2019 - 05/2017
2	Malignant Hypertension 06/2018 - 01/2018
2	Hemophilia A (Haemophilia) 11/2016 - 01/2007
2	Plasmablastic Lymphoma 03/2016 - 01/2007
1	Asthenia 01/2023
1	Body Weight (Weight, Body) 01/2023
1	Death (Near-Death Experience) 01/2023
1	Fatigue 01/2023
1	Headache (Headaches) 01/2023
1	Hypertension (High Blood Pressure) 01/2023
1	Nausea 01/2023
1	Circulating Neoplastic Cells 01/2023
1	Pneumonia (Pneumonitis) 01/2023
1	Syncope (Fainting) 01/2023
1	Iron Overload 01/2023
1	Hemolytic Anemia 10/2022
1	Thrombosis (Thrombus) 10/2022
1	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2021

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2017 - 04/2013
4	Histone Deacetylase InhibitorsIBA 07/2016 - 07/2012
4	Mechanistic Target of Rapamycin Complex 1IBA 01/2016 - 01/2013
3	ChromatinIBA 01/2022 - 01/2017
3	Azacitidine (5 Azacytidine)FDA Link 08/2021 - 12/2020
3	nilotinib FDA Link 01/2021 - 01/2019
3	Phosphotransferases (Kinase)IBA 01/2020 - 04/2013
3	thiamine triphosphorate (TTP)IBA 06/2018 - 11/2016
3	Bortezomib (Velcade)FDA Link 11/2016 - 01/2013
3	PanobinostatIBA 07/2016 - 12/2013
2	Tranexamic Acid (AMCA)FDA Link 12/2023 - 10/2023
2	venetoclaxIBA 05/2023 - 01/2020
2	Lenalidomide (CC 5013)FDA Link 01/2023 - 01/2023
2	Monoclonal AntibodiesIBA 01/2023 - 08/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2023 - 01/2023
2	von Willebrand FactorIBA 10/2022 - 09/2014
2	AutoantibodiesIBA 10/2022 - 04/2015
2	guadecitabineIBA 01/2022 - 12/2020
2	CytokinesIBA 01/2022 - 01/2020
2	EnzymesIBA 01/2022 - 02/2014
2	Thalidomide (Thalomid)FDA Link 11/2021 - 01/2014
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2021 - 07/2012
2	Rituximab (Mabthera)FDA Link 11/2021 - 11/2016
2	Tyrosine Kinase InhibitorsIBA 10/2021 - 01/2019
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2021 - 01/2019
2	Imatinib Mesylate (Gleevec)FDA Link 01/2019 - 05/2017
2	Shiga Toxin (Shigella Toxin)IBA 06/2018 - 01/2018
2	Ribosomal DNA (rDNA)IBA 01/2016 - 11/2013
2	Everolimus FDA Link 01/2016 - 01/2013
2	Oncogene Proteins (Oncogene Protein)IBA 07/2014 - 12/2012
2	Galactosylceramides (Galactocerebrosides)IBA 12/2013 - 10/2012
1	AnticoagulantsIBA 10/2023
1	idelalisibIBA 05/2023
1	ibrutinibIBA 05/2023
1	luspaterceptIBA 01/2023
1	zanubrutinibIBA 01/2023
1	myeloma-associated membrane antigen KMAIBA 01/2023
1	Epoetin Alfa (Epogen)FDA Link 01/2023
1	AntigensIBA 01/2023
1	Surface Antigens (Surface Antigen)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	HematinicsIBA 01/2023
1	Antiviral Agents (Antivirals)IBA 12/2022
1	ThrombospondinsIBA 10/2022
1	ADAMTS13 ProteinIBA 10/2022
1	Metalloproteases (Metalloproteinases)IBA 10/2022
1	ivosidenibIBA 01/2022
1	pyrimidineIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	alpha-hydroxyglutarateIBA 01/2022
1	Bispecific AntibodiesIBA 01/2022
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	Immunomodulating AgentsIBA 11/2021
1	CalciumIBA 10/2021

Therapy/Procedure

22	Therapeutics 12/2023 - 01/2013
4	Drug Therapy (Chemotherapy) 12/2021 - 07/2007
4	Stem Cell Transplantation 11/2021 - 01/2007
3	Transplantation 03/2024 - 07/2012
3	Immunotherapy 01/2022 - 10/2012
2	Platelet Transfusion (Blood Platelet Transfusions) 12/2023 - 10/2023
2	Erythrocyte Transfusion 01/2023 - 07/2008
1	Palliative Care (Palliative Therapy) 01/2023
1	Terminal Care (Care, Terminal) 01/2023
1	Precision Medicine 11/2021