Tomohiro Shimizu Selected Research

Osteoporosis

2/2024	Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia.
7/2023	Secondary fracture rates and risk factors 1 year after a proximal femoral fracture under FLS.
7/2022	Bone biopsy findings in patients receiving long-term bisphosphonate therapy for glucocorticoid-induced osteoporosis.
12/2021	Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.
1/2021	Risks vs. benefits of switching therapy in patients with postmenopausal osteoporosis.
10/2020	Comparison of the Efficacy and Renal Safety of Bisphosphonate Between Low-Dose/High-Frequency and High-Dose/Low-Frequency Regimens in a Late-Stage Chronic Kidney Disease Rat Model.
3/2020	Ten years change in post-fracture care for hip fracture patients.
11/2018	Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth.
1/2018	Drug therapy targeting pyrophosphate slows the ossification of spinal ligaments in twy mice.
2/2016	Teriparatide Improves Trabecular Osteoporosis but Simultaneously Promotes Ankylosis of the Spine in the Twy Mouse Model for Diffuse Idiopathic Skeletal Hyperostosis.

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Tomohiro Shimizu Research Topics

Disease

10	Osteoporosis 02/2024 - 02/2016
8	Bone Resorption 01/2022 - 12/2013
6	Rheumatoid Arthritis 07/2022 - 02/2015
5	Arthritis (Polyarthritis) 05/2024 - 02/2015
5	Postmenopausal Osteoporosis 09/2021 - 02/2015
5	Neoplasms (Cancer) 12/2019 - 11/2010
4	Osteonecrosis (Kienbock's Disease) 12/2023 - 01/2018
4	Osteoarthritis 11/2022 - 02/2015
4	Osteolysis 01/2022 - 01/2020
3	Synovitis 01/2022 - 02/2015
2	Heart Failure 12/2023 - 11/2021
2	Joint Instability (Joint Laxity) 01/2023 - 01/2019
2	Hip Dislocation 11/2022 - 04/2022
2	Inflammation (Inflammations) 01/2022 - 10/2015
2	Hypophosphatasia 09/2021 - 11/2020
2	Femoral Fractures (Femoral Fracture) 03/2021 - 11/2020
2	Disease Progression 11/2020 - 01/2019
2	Experimental Arthritis 12/2018 - 02/2015
2	Neoplasm Metastasis (Metastasis) 08/2013 - 01/2013
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2023
1	Developmental Dysplasia of the Hip 06/2023
1	Osteomyelitis 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2021
1	Unstable Angina 11/2021
1	Heart Diseases (Heart Disease) 11/2021
1	Myocardial Infarction 11/2021
1	Acute Coronary Syndrome 10/2021
1	Tooth Loss 11/2020
1	Chronic Renal Insufficiency 10/2020
1	Hip Fractures (Intertrochanteric Fractures) 03/2020
1	Breast Neoplasms (Breast Cancer) 12/2019
1	Bone Fractures (Bone Fracture) 03/2019
1	Hypocalcemia 03/2019
1	Non-alcoholic Fatty Liver Disease 02/2019
1	Thrombocytopenia (Thrombopenia) 02/2019
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 02/2019
1	Juvenile osteoporosis 11/2018

Drug/Important Bio-Agent (IBA)

6	Diphosphonates (Bisphosphonates)IBA 07/2023 - 09/2016
6	Proteins (Proteins, Gene)FDA Link 09/2016 - 12/2013
4	Collagen Type II (Type II Collagen)IBA 05/2024 - 02/2015
4	Therapeutic UsesIBA 01/2022 - 12/2018
3	Denosumab FDA Link 02/2024 - 11/2020
3	Alkaline PhosphataseIBA 09/2021 - 01/2018
3	Teriparatide (Parathar)FDA Link 03/2019 - 02/2016
3	Immunoglobulins (Immunoglobulin)IBA 11/2018 - 02/2015
3	LectinsIBA 11/2018 - 02/2015
3	N-Acetylneuraminic Acid (Sialic Acid)IBA 11/2018 - 02/2015
2	ultra-high molecular weight polyethylene (UHMWPE)IBA 01/2022 - 01/2020
2	Zoledronic Acid (Zometa)FDA Link 01/2022 - 09/2021
2	LigandsIBA 01/2022 - 12/2013
2	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 10/2021
2	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 09/2021 - 11/2020
2	Polyethylene (Polythene)IBA 09/2021 - 01/2020
2	Bone Density Conservation AgentsIBA 11/2020 - 03/2019
2	AntigensIBA 12/2019 - 10/2015
1	itaconic acidIBA 05/2024
1	CollagenIBA 05/2024
1	ZincIBA 02/2024
1	Methylprednisolone FDA LinkGeneric 12/2023
1	Tolvaptan FDA Link 12/2023
1	Collagenases (Collagenase)FDA Link 01/2023
1	CaspasesIBA 01/2023
1	GlucocorticoidsIBA 07/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	Annexin A1IBA 01/2022
1	InflammasomesIBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	InterferonsIBA 12/2021
1	cardiotrophin-like cytokineIBA 12/2021
1	Immunologic Factors (Immunomodulators)IBA 12/2021
1	AcidsIBA 09/2021
1	saracatinibIBA 09/2021
1	Vitamin D FDA LinkGeneric 09/2021
1	Thymidine PhosphorylaseIBA 09/2021
1	Phosphotransferases (Kinase)IBA 09/2021
1	ElementsIBA 03/2021
1	lymphotactinIBA 01/2020
1	ChemokinesIBA 01/2020
1	sialosyl-Tn antigenIBA 12/2019
1	Polysaccharides (Glycans)IBA 12/2019
1	EpitopesIBA 12/2019
1	CarbohydratesIBA 12/2019
1	IntegrinsIBA 12/2019
1	Selective Estrogen Receptor Modulators (SERM)IBA 03/2019
1	eldecalcitol (ED 71)IBA 03/2019
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2019
1	ametantrone (HAQ)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Neutralizing AntibodiesIBA 11/2018

Therapy/Procedure

17	Therapeutics 12/2023 - 08/2013
3	Intra-Articular Injections 05/2024 - 02/2015
3	Osteotomy 06/2023 - 01/2018
2	Hip Replacement Arthroplasty (Total Hip Replacement) 06/2023 - 04/2022
2	Arthroplasty 01/2022 - 01/2020
2	Anterior Cruciate Ligament Reconstruction 01/2020 - 01/2019
1	Injections 01/2022
1	Oral Administration 09/2021
1	Drug Therapy (Chemotherapy) 03/2020
1	Postoperative Care 03/2020