Ana Sevilla Selected Research

Phosphotransferases (Kinase)

7/2012	Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
9/2007	Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations.
8/2006	Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling.
3/2006	VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.
12/2004	p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.
11/2004	c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).
6/2004	Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.

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Ana Sevilla Research Topics

Disease

6	Vaccinia 07/2012 - 06/2004
4	Neoplasms (Cancer) 01/2024 - 10/2015
1	Phototoxic Dermatitis (Phototoxicity) 01/2024
1	Glioblastoma (Glioblastoma Multiforme) 10/2023
1	Myocardial Ischemia (Ischemic Heart Diseases) 02/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Neuroinflammatory Diseases 01/2020
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020
1	Pathologic Processes 01/2019
1	Zika Virus Infection 01/2019
1	Carcinogenesis 10/2015
1	Ataxia Telangiectasia (Louis Bar Syndrome) 07/2012
1	Hypertelorism 06/2010
1	LEOPARD Syndrome (Syndrome, LEOPARD) 06/2010
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 06/2010
1	Pulmonary Valve Stenosis (Pulmonary Stenosis) 06/2010
1	Deafness (Deaf Mutism) 06/2010
1	Lentigo (Lentiginosis) 06/2010
1	Infections 08/2006
1	Virus Diseases (Viral Diseases) 08/2006
1	Squamous Cell Carcinoma of Head and Neck 03/2006
1	Retinoblastoma (Glioblastoma, Retinal) 03/2006

Drug/Important Bio-Agent (IBA)

7	Phosphotransferases (Kinase)IBA 07/2012 - 06/2004
3	Proteins (Proteins, Gene)FDA Link 07/2012 - 03/2006
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2024 - 10/2023
2	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2019
1	Oxygen (Dioxygen)IBA 01/2024
1	Photosensitizing Agents (Photosensitizers)IBA 01/2024
1	regadenoson FDA Link 02/2021
1	MethyltransferasesIBA 01/2019
1	MicroRNAs (MicroRNA)IBA 10/2015
1	Small Interfering RNA (siRNA)IBA 07/2012
1	Mitogen-Activated Protein KinasesIBA 06/2010
1	EpitopesIBA 09/2007
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 08/2006
1	Viral ProteinsIBA 08/2006

Therapy/Procedure

2	Therapeutics 01/2024 - 10/2023
2	Photochemotherapy (Photodynamic Therapy) 01/2024 - 10/2023
1	Quantum Dots (Quantum Dot) 01/2024
1	Radiotherapy 01/2024
1	Immunotherapy 01/2024
1	Immunomodulation 01/2020