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Tin Sein Selected Research

Amphotericin B (Amphotericin)

3/2010Effects of immunomodulatory and organism-associated molecules on the permeability of an in vitro blood-brain barrier model to amphotericin B and fluconazole.
10/2006Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations.
10/2006Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation.
4/2006Multidimensional volumetric imaging of pulmonary infiltrates for measuring therapeutic response to antifungal therapy in experimental invasive pulmonary aspergillosis.
5/2005Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.
10/2004Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.
7/2003Experimental pulmonary aspergillosis due to Aspergillus terreus: pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B.
6/2002Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits.
1/2002Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia.

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Tin Sein Research Topics

Disease

8Invasive Pulmonary Aspergillosis
12/2011 - 01/2002
7Body Weight (Weight, Body)
06/2009 - 01/2002
6Aspergillosis
09/2008 - 01/2002
4Pulmonary Aspergillosis
06/2009 - 01/2002
4Infections
09/2008 - 07/2003
4Candidiasis (Moniliasis)
01/2006 - 06/2002
3Mycoses (Diseases, Fungus)
03/2010 - 09/2008
3Lung Injury
06/2009 - 01/2002
2Invasive Fungal Infections
02/2009 - 06/2008
2Zygomycosis (Phycomycosis)
11/2008 - 09/2005
2Invasive Candidiasis
06/2008 - 01/2006
2Pulmonary Infarction
06/2002 - 01/2002
1Herpes Zoster
03/2010
1Infarction (Infarctions)
06/2009
1Neoplasms (Cancer)
09/2008
1Central Nervous System Infections (Central Nervous System Infection)
05/2005
1Persistent Infection
07/2003

Drug/Important Bio-Agent (IBA)

9Amphotericin B (Amphotericin)FDA LinkGeneric
03/2010 - 01/2002
6galactomannanIBA
06/2009 - 01/2002
4Anti-Bacterial Agents (Antibiotics)IBA
12/2011 - 10/2004
3AntigensIBA
09/2008 - 01/2002
3liposomal amphotericin BFDA Link
10/2006 - 06/2002
3Deoxycholic Acid (Sodium Deoxycholate)IBA
04/2006 - 01/2002
2Dihydrotachysterol (AT 10)IBA
06/2009 - 05/2005
2Antifungal AgentsIBA
02/2009 - 06/2008
2Biomarkers (Surrogate Marker)IBA
11/2008 - 04/2006
2EnzymesIBA
09/2008 - 10/2004
2ER 30346 (ravuconazole)IBA
10/2006 - 06/2003
2TriazolesIBA
10/2006 - 06/2003
2Isoleucine-tRNA LigaseIBA
05/2005 - 10/2004
22- amino- 4- methylenecyclopentane- 1- carboxylic acidIBA
05/2005 - 10/2004
2Fluconazole (Zonal)FDA LinkGeneric
05/2005 - 10/2004
2Micafungin (FK463)FDA Link
06/2003 - 06/2002
2EchinocandinsIBA
06/2003 - 01/2002
1Tight Junction ProteinsIBA
03/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2010
1Voriconazole (Vfend)FDA LinkGeneric
06/2009
1AnidulafunginFDA Link
06/2009
1FluoroquinolonesIBA
02/2009
128S Ribosomal RNAIBA
11/2008
1deoxycholate drug combination amphotericin BIBA
10/2006
1Fungal DNAIBA
01/2006
1DNA (Deoxyribonucleic Acid)IBA
01/2006
1Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric
10/2004
1ImmunosorbentsIBA
10/2004
1OMPIIBA
01/2002
1Caspofungin (Cancidas)FDA Link
01/2002

Therapy/Procedure

10Therapeutics
06/2009 - 01/2002
1Drug Therapy (Chemotherapy)
02/2007
1Injections
10/2004