H Martin Seidel Selected Research

Liver Diseases (Liver Disease)

12/2017

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

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H Martin Seidel Research Topics

Disease

3	Neoplasms (Cancer) 05/2015 - 02/2012
2	Non-alcoholic Fatty Liver Disease 01/2020 - 12/2017
2	Fibrosis (Cirrhosis) 01/2020 - 01/2017
2	Autoimmune Diseases (Autoimmune Disease) 01/2015 - 04/2014
1	Inflammation (Inflammations) 01/2020
1	Cholestasis 12/2017
1	Liver Diseases (Liver Disease) 12/2017
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2017
1	Bronchiolitis Obliterans Syndrome 01/2017
1	Carcinogenesis 05/2015
1	Immune System Diseases (Immune Disorders) 01/2015
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2014
1	Breast Neoplasms (Breast Cancer) 12/2013
1	Head and Neck Neoplasms (Head and Neck Cancer) 12/2013
1	Squamous Cell Carcinoma of Head and Neck 12/2013
1	Weight Loss (Weight Reduction) 12/2011
1	Infections 10/2002
1	Virus Diseases (Viral Diseases) 10/2002

Drug/Important Bio-Agent (IBA)

2	Bile Acids and Salts (Bile Acids)IBA 12/2017 - 04/2014
2	Phosphotransferases (Kinase)IBA 05/2015 - 01/2015
1	LipidsIBA 01/2020
1	tropifexorIBA 12/2017
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017
1	GNF6231IBA 01/2017
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2017
1	TropomyosinIBA 05/2015
1	Antigen Receptors (Antigen Receptor)IBA 01/2015
1	Inositol (Myoinositol)IBA 01/2015
1	GTP-Binding Proteins (G-Protein)IBA 04/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 04/2014
1	LGK974IBA 12/2013
1	Nerve Growth Factor (NGF)IBA 02/2012
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 12/2011
1	CannabinoidsIBA 12/2011
1	Indicators and Reagents (Reagents)IBA 10/2002
1	Proteins (Proteins, Gene)FDA Link 10/2002
1	PolylysineIBA 10/2002
1	Poly IIBA 10/2002
1	Messenger RNA (mRNA)IBA 10/2002
1	Double-Stranded RNA (RNA, Double Stranded)IBA 10/2002
1	AcidsIBA 10/2002

Therapy/Procedure

1	Therapeutics 01/2020