David Segal Selected Research

Lapatinib (GW572016)

8/2017

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

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David Segal Research Topics

Disease

14	Neoplasms (Cancer) 01/2020 - 05/2006
7	Infections 10/2021 - 09/2007
5	Obesity 01/2023 - 10/2007
4	Leukemia 01/2019 - 01/2011
3	Multiple Myeloma 01/2020 - 10/2016
3	Insulin Resistance 01/2020 - 06/2002
3	Type 2 Diabetes Mellitus (MODY) 01/2012 - 06/2002
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2010 - 10/2007
2	Femoral Neck Fractures 12/2023 - 07/2023
2	Hallux Valgus 10/2023 - 09/2022
2	Congenital Abnormalities (Deformity) 10/2023 - 09/2022
2	Pain (Aches) 02/2023 - 04/2012
2	COVID-19 10/2022 - 01/2020
2	Osteomyelitis 07/2021 - 07/2015
2	Wounds and Injuries (Trauma) 03/2020 - 12/2002
2	Tibial Fractures (Fracture, Tibial) 03/2007 - 12/2002
1	Tendinopathy (Tendonitis) 01/2024
1	Hip Fractures (Intertrochanteric Fractures) 07/2023
1	Overweight 01/2023
1	Metatarsus Varus 09/2022
1	Hemorrhage 10/2021
1	Sepsis (Septicemia) 07/2021
1	Ulcer 05/2021
1	Birth Injuries (Birth Injury) 07/2019
1	Rheumatoid Arthritis 01/2019
1	Experimental Arthritis 01/2019
1	Arthritis (Polyarthritis) 01/2019
1	Melanoma (Melanoma, Malignant) 01/2019
1	Neutropenia 08/2017
1	Triple Negative Breast Neoplasms 08/2017
1	Breast Neoplasms (Breast Cancer) 08/2017
1	Necrosis 01/2017
1	Lymphoma (Lymphomas) 10/2016
1	Bacterial Infections (Bacterial Infection) 06/2012
1	Inflammation (Inflammations) 04/2012

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2019 - 10/2007
3	Anti-Bacterial Agents (Antibiotics)IBA 07/2021 - 06/2012
3	S63845IBA 01/2019 - 10/2016
3	AdipokinesIBA 05/2010 - 10/2007
2	Hyaluronic Acid (Hyaluronan)IBA 01/2024 - 02/2011
2	Warfarin (Coumadin)FDA LinkGeneric 02/2023 - 07/2003
2	Hemostatics (Antihemorrhagics)IBA 10/2021 - 02/2020
2	Bortezomib (Velcade)FDA Link 01/2020 - 01/2019
2	Phosphotransferases (Kinase)IBA 01/2019 - 08/2017
2	Insulin (Novolin)FDA Link 08/2009 - 06/2002
2	Growth Hormone (Somatotropin)IBA 03/2009 - 03/2007
1	Enoxaparin (Lovenox)FDA LinkGeneric 02/2023
1	Vitamin D FDA LinkGeneric 01/2023
1	BNT162 VaccineIBA 10/2022
1	SolutionsIBA 09/2022
1	Biomarkers (Surrogate Marker)IBA 02/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2020
1	S55746IBA 01/2019
1	Therapeutic UsesIBA 01/2019
1	Proteasome InhibitorsIBA 01/2019
1	AutoantibodiesIBA 01/2019
1	AntigensIBA 01/2019
1	dactolisibIBA 08/2017
1	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA 08/2017
1	Trastuzumab (Herceptin)FDA Link 08/2017
1	Docetaxel (Taxotere)FDA Link 08/2017
1	Lapatinib (GW572016)FDA Link 08/2017
1	InterferonsIBA 01/2017
1	Apoptosis Regulatory ProteinsIBA 01/2017
1	Inhibitor of Apoptosis ProteinsIBA 01/2017
1	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 10/2016
1	venetoclaxIBA 01/2016
1	LipidsIBA 07/2015
1	PolymersIBA 07/2015
1	TitaniumIBA 07/2015
1	AlloysIBA 07/2015
1	Doxycycline (Periostat)FDA LinkGeneric 07/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2013
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 07/2012
1	Analgesics (Analgesic Drugs)IBA 04/2012
1	Freund's AdjuvantIBA 04/2012
1	Small Leucine-Rich ProteoglycansIBA 01/2012
1	BiglycanIBA 01/2012
1	DecorinIBA 01/2012
1	bisbenzimide ethoxide trihydrochloride (Hoechst 33342)IBA 12/2011
1	CYT997IBA 12/2011

Therapy/Procedure

7	Therapeutics 11/2019 - 07/2003
4	Cesarean Section (Caesarean Section) 10/2021 - 07/2003
3	Osteotomy 10/2023 - 05/2021
2	Hemiarthroplasty 12/2023 - 08/2021
2	Hip Replacement Arthroplasty (Total Hip Replacement) 12/2023 - 07/2023
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2019
1	Injections 01/2024
1	Orthopedic Procedures 07/2023
1	Minimally Invasive Surgical Procedures 09/2022
1	Operative Time 08/2021
1	Patient Readmission 07/2021
1	Surgical Amputation (Amputations) 07/2021
1	Obstetrical Vacuum Extraction 03/2020
1	Nerve Transfer 07/2019
1	Analgesia 04/2012