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Beat W Schäfer Selected Research

Neoplasms (Cancer)

1/2024The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture.
12/2023Elimusertib has Antitumor Activity in Preclinical Patient-Derived Pediatric Solid Tumor Models.
10/2023Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
10/2023Retraction notice to Corrigendum to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia 31 (2022) 100805].
10/2023Retraction notice to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia 27 (2022) 100784].
10/2022Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study.
9/2022Corrigendum to "Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization" [Neoplasia volume 27 (2022) pp. 100784/Number C].
1/2022Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization.
1/2022CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma.
11/2021BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma.
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Beat W Schäfer Research Topics

Disease

46Neoplasms (Cancer)
01/2024 - 05/2002
19Rhabdomyosarcoma
10/2022 - 10/2002
14Ewing Sarcoma (Sarcoma, Ewing)
01/2024 - 11/2012
12Alveolar Rhabdomyosarcoma
12/2023 - 08/2004
11Sarcoma (Soft Tissue Sarcoma)
03/2024 - 06/2010
8Genetic Translocation (Chromosomal Translocation)
03/2024 - 07/2009
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2024 - 01/2005
3Embryonal Rhabdomyosarcoma
01/2021 - 08/2004
3Carcinogenesis
01/2020 - 08/2015
2Neoplasm Metastasis (Metastasis)
01/2021 - 01/2016
2Bone Neoplasms (Bone Cancer)
01/2021 - 10/2015
2Leukemia
01/2018 - 08/2015
2Lymphoma (Lymphomas)
06/2009 - 07/2003
2Carcinoma (Carcinomatosis)
08/2005 - 04/2002
1Ataxia Telangiectasia (Louis Bar Syndrome)
12/2023
1Thyroid Neoplasms (Thyroid Cancer)
08/2015
1Neuroblastoma
01/2013
1Familial cylindromatosis
04/2010
1Glucocorticoid Receptor Deficiency
04/2010
1Melanoma (Melanoma, Malignant)
07/2009
1Glioma (Gliomas)
07/2009
1Breast Neoplasms (Breast Cancer)
07/2009
1Squamous Cell Carcinoma of Head and Neck
08/2005
1Residual Neoplasm
01/2005
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2004
1Inflammation (Inflammations)
04/2004

Drug/Important Bio-Agent (IBA)

24Proteins (Proteins, Gene)FDA Link
03/2024 - 04/2002
10Transcription Factors (Transcription Factor)IBA
01/2024 - 05/2008
9EWS-FLI fusion proteinIBA
01/2024 - 12/2016
7Oncogene Proteins (Oncogene Protein)IBA
01/2022 - 02/2016
4ChromatinIBA
01/2024 - 01/2020
3Phosphotransferases (Kinase)IBA
03/2024 - 04/2010
3FenretinideIBA
01/2021 - 01/2013
3Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA
11/2016 - 05/2010
3FurinIBA
11/2016 - 05/2010
3S100 Proteins (S 100 Protein)IBA
04/2004 - 05/2002
2Biomarkers (Surrogate Marker)IBA
10/2022 - 06/2009
2DNA (Deoxyribonucleic Acid)IBA
10/2022 - 11/2014
2AntibodiesIBA
01/2021 - 11/2020
2Vincristine (Oncovin)FDA LinkGeneric
11/2020 - 01/2019
2PAX3 Transcription FactorIBA
01/2015 - 05/2008
2Dexamethasone (Maxidex)FDA LinkGeneric
04/2010 - 09/2007
2GlucocorticoidsIBA
04/2010 - 09/2007
2Cadherins (E-Cadherin)IBA
06/2009 - 02/2006
1Immunoglobulins (Immunoglobulin)IBA
05/2024
1olaparibIBA
01/2024
1Cysteine (L-Cysteine)FDA Link
12/2023
1PlasticsIBA
10/2023
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2023
1Circulating Tumor DNAIBA
10/2022
1fimepinostatIBA
01/2022
1Verteporfin (Visudyne)FDA Link
01/2021
1Monoclonal AntibodiesIBA
01/2021
1Single-Domain AntibodiesIBA
11/2020
1Type 4 Fibroblast Growth Factor ReceptorIBA
11/2020
1Liposomes (Liposome)IBA
11/2020
1Carrier Proteins (Binding Protein)IBA
01/2020
1navitoclaxIBA
01/2020
1Mi-2 Nucleosome Remodeling and Deacetylase ComplexIBA
01/2020
1Aurora Kinase AIBA
01/2020
1Dynamins (Dynamin)IBA
01/2020
1BI 6727IBA
01/2019
1Deubiquitinating EnzymesIBA
01/2019
1RNA (Ribonucleic Acid)IBA
02/2016
1BI 2536IBA
01/2015
1midostaurinIBA
11/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2011
1tyrosine receptor (receptor, tyrosine)IBA
06/2010
1Histone Deacetylases (Histone Deacetylase)IBA
06/2010
1Proteasome Endopeptidase Complex (Proteasome)IBA
06/2010
1Sirolimus (Rapamycin)FDA Link
04/2010
1obatoclaxIBA
04/2010
1Cytotoxins (Cytolysins)IBA
04/2010
1Dronabinol (THC)FDA LinkGeneric
07/2009
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
07/2009
1Cannabinoid Receptor AgonistsIBA
07/2009
1HU 211 (HU 210)IBA
07/2009
1Fibrillin-2IBA
06/2009
1Peptides (Polypeptides)IBA
05/2009
1Arsenic Trioxide (Trisenox)FDA Link
09/2007
1Messenger RNA (mRNA)IBA
01/2007
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2007
1Calcium-Binding ProteinsIBA
08/2005
1Hydroxyurea (Hydrea)FDA LinkGeneric
08/2005
1Small Interfering RNA (siRNA)IBA
10/2004
1Paired Box Transcription Factors (Pax Transcription Factors)IBA
10/2004
1PAX5 Transcription FactorIBA
10/2004
1OligonucleotidesIBA
08/2004
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
08/2004
1Pyridinolcarbamate (P23)IBA
08/2004
1Myosins (Myosin)IBA
05/2004
1Tumor Biomarkers (Tumor Markers)IBA
07/2003
1S100A12 ProteinIBA
07/2003
1Receptor for Advanced Glycation End ProductsIBA
07/2003

Therapy/Procedure

16Therapeutics
01/2021 - 10/2004
4Drug Therapy (Chemotherapy)
12/2023 - 04/2010
2Radiotherapy
01/2021 - 01/2021
1Combined Modality Therapy
02/2016
1Investigational Therapies (Experimental Therapy)
01/2013
1Combination Drug Therapy (Combination Chemotherapy)
08/2011