Yuko Saito Selected Research

Amyloid (Amyloid Fibrils)

12/2023	Distinct tau folds initiate templated seeding and alter the post-translational modification profile.
1/2023	O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production.
1/2023	CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease.
1/2023	Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
5/2022	Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
2/2022	Soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for differential diagnosis of mild cognitive impairment.
1/2022	Age-dependent formation of TMEM106B amyloid filaments in human brains.
1/2021	Human tauopathy-derived tau strains determine the substrates recruited for templated amplification.
11/2020	Reactive astrocytes express Aggregatin (FAM222A) in the brains of Alzheimer's disease and Nasu-Hakola disease.
2/2018	Alzheimer's disease pathology in Nasu-Hakola disease brains.

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Yuko Saito Research Topics

Disease

42	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 09/2002
19	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2024 - 04/2005
13	Parkinson Disease (Parkinson's Disease) 10/2023 - 06/2003
12	Amyloid Plaque 12/2023 - 01/2004
12	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2023 - 05/2004
11	Tauopathies 12/2023 - 03/2007
11	Dementia (Dementias) 12/2023 - 05/2004
9	Neoplasms (Cancer) 05/2019 - 01/2007
7	Corticobasal Degeneration 12/2023 - 08/2013
7	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 12/2023 - 08/2013
6	Cognitive Dysfunction 02/2024 - 06/2004
6	Frontotemporal Dementia (Semantic Dementia) 10/2023 - 01/2014
6	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 04/2021 - 10/2011
5	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 11/2018 - 04/2012
4	Atrophy 02/2024 - 08/2005
4	Pick Disease of the Brain (Pick's Disease) 12/2023 - 02/2015
4	Lewy Body Disease (Lewy Body Dementia) 10/2023 - 01/2014
4	Parkinsonian Disorders (Parkinsonism) 01/2023 - 04/2011
4	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 09/2020 - 05/2013
3	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 04/2024 - 11/2009
3	Proteostasis Deficiencies 03/2022 - 11/2012
3	Synucleinopathies 01/2022 - 09/2015
3	Gliosis 08/2021 - 08/2014
3	Bone Cysts (Bone Cyst) 02/2018 - 04/2012
3	Hemimegalencephaly 05/2017 - 12/2009
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2023 - 03/2012
2	Neuronal intranuclear inclusion disease 01/2023 - 05/2021
2	Amyloidosis 01/2022 - 11/2008
2	Sporadic Creutzfeldt-Jakob Disease 05/2021 - 01/2019
2	Leukoencephalopathies 05/2021 - 12/2015
2	Neoplasm Metastasis (Metastasis) 04/2019 - 05/2006
2	Disease Progression 04/2019 - 01/2017
2	Epilepsy (Aura) 06/2018 - 08/2014
2	Tuberous Sclerosis (Bourneville's Disease) 05/2017 - 10/2015
2	Focal Cortical Dysplasia 05/2017 - 10/2015
2	Periodontal Diseases (Periodontal Disease) 05/2016 - 01/2016
2	Seizures (Absence Seizure) 06/2015 - 09/2013
2	Infections 01/2015 - 05/2013
2	Anemia 04/2013 - 01/2007
2	Cerebellar Ataxia (Dysmetria) 02/2007 - 08/2005
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2005 - 09/2002
1	Death (Near-Death Experience) 12/2023
1	Cholangiocarcinoma 08/2023
1	Hemorrhage 08/2023

Drug/Important Bio-Agent (IBA)

24	Proteins (Proteins, Gene)FDA Link 12/2023 - 07/2004
15	Amyloid (Amyloid Fibrils)IBA 12/2023 - 01/2010
12	SynucleinsIBA 10/2023 - 04/2011
10	Biomarkers (Surrogate Marker)IBA 02/2024 - 10/2011
8	Amyloid beta-PeptidesIBA 03/2024 - 09/2002
6	DNA-Binding Proteins (DNA Binding Protein)IBA 03/2022 - 11/2012
5	PrionsIBA 01/2023 - 08/2013
5	alpha-SynucleinIBA 01/2022 - 06/2003
5	tau Proteins (tau Protein)IBA 12/2021 - 10/2011
3	Homovanillic AcidIBA 01/2023 - 01/2017
3	Messenger RNA (mRNA)IBA 11/2020 - 06/2007
3	NucleotidesIBA 09/2020 - 08/2005
3	Prion ProteinsIBA 01/2019 - 08/2007
3	AntibodiesIBA 06/2015 - 08/2012
3	Apolipoproteins E (ApoE)IBA 09/2004 - 04/2004
2	CytokinesIBA 04/2024 - 03/2008
2	Apolipoprotein E4IBA 12/2023 - 05/2004
2	5-hydroxyindoleIBA 01/2023 - 01/2017
2	Acetic Acid (Vinegar)FDA LinkGeneric 01/2023 - 01/2017
2	LipidsIBA 01/2022 - 02/2018
2	Methionine (L-Methionine)FDA Link 12/2021 - 01/2019
2	EnzymesIBA 11/2021 - 01/2006
2	IronIBA 08/2021 - 05/2015
2	sarkosylIBA 01/2020 - 02/2016
2	polyglutamineIBA 01/2020 - 03/2017
2	Docetaxel (Taxotere)FDA Link 04/2019 - 05/2006
2	Codon (Codons)IBA 01/2019 - 07/2010
2	Polysaccharides (Glycans)IBA 01/2017 - 01/2010
2	Butyric Acid (Butanoic Acid)IBA 05/2016 - 01/2016
2	Glial Fibrillary Acidic ProteinIBA 11/2015 - 08/2014
2	UbiquitinIBA 06/2015 - 05/2004
2	Protein Isoforms (Isoforms)IBA 02/2014 - 08/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 05/2006
2	EpitopesIBA 08/2013 - 01/2013
2	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 08/2013 - 10/2011
2	3-Iodobenzylguanidine (Iobenguane)IBA 10/2011 - 04/2006
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 07/2004 - 05/2004
2	ApolipoproteinsIBA 07/2004 - 09/2002
1	Ataxin-1IBA 04/2024
1	Histones (Histone)IBA 04/2024
1	RNA (Ribonucleic Acid)IBA 04/2024
1	RNA Splicing FactorsIBA 04/2024
1	Polyvinyl Chloride (PVC)IBA 12/2023
1	CopperIBA 12/2023
1	14-3-3 Proteins (14-3-3 Protein)IBA 12/2023
1	Adenine FDA LinkGeneric 10/2023
1	ThymidineIBA 10/2023
1	Monoclonal AntibodiesIBA 08/2023
1	tilavonemabIBA 08/2023
1	Inositol (Myoinositol)IBA 01/2023
1	Threonine (L-Threonine)FDA Link 01/2023
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2023
1	diphosphoric acid (pyrophosphoric acid)IBA 01/2023

Therapy/Procedure

11	Therapeutics 04/2024 - 07/2004
4	Drug Therapy (Chemotherapy) 04/2019 - 04/2013
2	Palliative Care (Palliative Therapy) 05/2017 - 12/2012