Marc S Sabatine Selected Research

Cholesterol

1/2022	No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab.
12/2020	Cognition After Lowering LDL-Cholesterol With Evolocumab.
11/2020	Clinical Application of High-Sensitivity Troponin Testing in the Atherosclerotic Cardiovascular Disease Framework of the Current Cholesterol Guidelines.
1/2020	Efficacy of Evolocumab on Cardiovascular Outcomes in Patients With Recent Myocardial Infarction: A Prespecified Secondary Analysis From the FOURIER Trial.
1/2020	The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism.
2/2014	AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57).
1/2012	Design and rationale of the LAPLACE-TIMI 57 trial: a phase II, double-blind, placebo-controlled study of the efficacy and tolerability of a monoclonal antibody inhibitor of PCSK9 in subjects with hypercholesterolemia on background statin therapy.
1/2011	Genetic variants in the KIF6 region and coronary event reduction from statin therapy.
1/2008	Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
11/2005	Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.

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Marc S Sabatine Research Topics

Disease

191	Myocardial Infarction 04/2024 - 04/2002
118	Heart Failure 05/2024 - 05/2004
90	Acute Coronary Syndrome 01/2023 - 04/2002
73	Cardiovascular Diseases (Cardiovascular Disease) 02/2024 - 04/2002
63	Stroke (Strokes) 04/2024 - 09/2005
50	ST Elevation Myocardial Infarction 01/2022 - 11/2002
47	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2018
41	Hemorrhage 12/2022 - 09/2005
38	Coronary Artery Disease (Coronary Atherosclerosis) 03/2024 - 11/2002
23	Thrombosis (Thrombus) 01/2021 - 07/2002
22	Unstable Angina 01/2023 - 06/2002
19	Ischemic Stroke 02/2024 - 03/2016
19	Ischemia 12/2023 - 04/2003
18	Atherosclerosis 02/2024 - 02/2003
18	Coronary Disease (Coronary Heart Disease) 02/2024 - 02/2003
16	Diabetes Mellitus 12/2023 - 04/2006
15	Peripheral Arterial Disease 02/2024 - 03/2016
15	Infections 01/2023 - 04/2006
13	Hypertension (High Blood Pressure) 01/2023 - 02/2003
12	Atrial Fibrillation 01/2023 - 06/2015
12	Non-ST Elevated Myocardial Infarction 01/2023 - 06/2002
12	Infarction (Infarctions) 01/2022 - 07/2002
11	Myocardial Ischemia (Ischemic Heart Diseases) 09/2016 - 07/2002
10	Hypercholesterolemia 07/2022 - 01/2012
9	Inflammation (Inflammations) 02/2024 - 02/2003
9	Chronic Renal Insufficiency 11/2023 - 04/2006
8	Cardiomyopathies (Cardiomyopathy) 05/2024 - 01/2020
8	Kidney Diseases (Kidney Disease) 10/2023 - 01/2019
6	Obesity 12/2023 - 12/2012
5	Hemorrhagic Stroke 01/2023 - 09/2016
5	Necrosis 01/2023 - 02/2003
5	Vascular Diseases (Vascular Disease) 09/2019 - 03/2016
5	Weight Loss (Weight Reduction) 01/2019 - 01/2018
4	Genetic Risk Score 01/2023 - 10/2019
4	Injection Site Reaction 11/2022 - 01/2017
4	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 05/2014
4	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

85	dapagliflozinIBA 05/2024 - 01/2018
47	Clopidogrel (Plavix)FDA Link 11/2022 - 02/2005
45	evolocumabIBA 02/2024 - 01/2012
44	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023 - 06/2006
38	Biomarkers (Surrogate Marker)IBA 01/2023 - 04/2002
33	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2022 - 02/2003
32	oxidized low density lipoproteinIBA 12/2023 - 11/2005
30	Brain Natriuretic Peptide (Natrecor)FDA Link 05/2024 - 04/2002
30	LDL CholesterolIBA 12/2023 - 06/2007
29	omega-Chloroacetophenone (Mace)IBA 04/2024 - 06/2007
28	TicagrelorIBA 01/2023 - 11/2013
25	C-Reactive ProteinIBA 02/2024 - 04/2002
22	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 02/2008
21	Sodium-Glucose Transport ProteinsIBA 10/2023 - 01/2019
18	SodiumIBA 04/2024 - 01/2018
17	Troponin IIBA 01/2021 - 04/2002
16	Proprotein Convertase 9IBA 12/2023 - 08/2013
16	Pravastatin (Pravachol)FDA LinkGeneric 09/2015 - 11/2005
15	LipidsIBA 12/2023 - 01/2012
15	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2023 - 01/2018
15	Heparin (Liquaemin)FDA LinkGeneric 03/2021 - 03/2005
13	Troponin T (Troponin T1)IBA 01/2022 - 01/2006
13	Glycoproteins (Glycoprotein)IBA 01/2020 - 11/2002
13	Atorvastatin (Lipitor)FDA Link 09/2019 - 04/2006
12	pro-brain natriuretic peptide (1-76)IBA 12/2023 - 07/2007
11	otamixabanIBA 01/2023 - 09/2009
10	TroponinIBA 01/2022 - 01/2006
10	CholesterolIBA 01/2022 - 11/2005
10	Tirofiban (Aggrastat)FDA Link 11/2020 - 07/2002
10	Prasugrel Hydrochloride FDA Link 01/2020 - 01/2009
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2008
8	CreatinineIBA 10/2023 - 03/2009
7	Lipoprotein(a)IBA 02/2024 - 08/2013
7	Eptifibatide (Integrilin)FDA Link 03/2021 - 09/2009
7	Neurofibromin 2 (Merlin)IBA 01/2021 - 03/2010
7	Enoxaparin (Lovenox)FDA LinkGeneric 03/2009 - 06/2002
6	SymportersIBA 04/2024 - 01/2019
6	Natriuretic PeptidesIBA 12/2023 - 11/2004
6	DiureticsIBA 01/2023 - 02/2008
6	Troleandomycin (TAO)FDA Link 01/2023 - 09/2013
6	Ranolazine FDA Link 01/2021 - 03/2010
6	Cytochrome P-450 CYP2C19IBA 01/2016 - 01/2009
5	HDL CholesterolIBA 04/2024 - 03/2016
5	Monoclonal AntibodiesIBA 12/2023 - 01/2012
5	AlbuminsIBA 10/2023 - 01/2019
5	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 04/2021 - 01/2016
5	trandolapril (Mavik)FDA LinkGeneric 01/2019 - 03/2007
4	Triglycerides (Triacylglycerol)IBA 04/2024 - 06/2011
4	AnticoagulantsIBA 11/2022 - 09/2013
4	vorapaxarIBA 08/2022 - 10/2012
4	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 08/2022 - 12/2005
4	HDL LipoproteinsIBA 01/2022 - 01/2019
4	saxagliptin FDA Link 11/2021 - 11/2019
4	Simvastatin (Zocor)FDA LinkGeneric 10/2021 - 07/2006
4	lorcaserinIBA 01/2019 - 01/2018

Therapy/Procedure

123	Therapeutics 04/2024 - 07/2002
27	Percutaneous Coronary Intervention 03/2024 - 09/2004
17	Stents 03/2024 - 01/2009
17	Thrombolytic Therapy 01/2021 - 01/2005
11	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 03/2024 - 04/2007
10	Secondary Prevention 01/2021 - 10/2012
8	Surgical Amputation (Amputations) 10/2023 - 01/2018
5	Patient Readmission 07/2012 - 02/2004