Brent J Ryan Selected Research

Frontotemporal Dementia (Semantic Dementia)

11/2023

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

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Brent J Ryan Research Topics

Disease

13	Parkinson Disease (Parkinson's Disease) 01/2023 - 02/2014
6	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2023 - 03/2016
6	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 02/2014
3	Rheumatoid Arthritis 01/2014 - 04/2013
2	Autoimmune Diseases (Autoimmune Disease) 01/2014 - 01/2014
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 11/2023
1	Frontotemporal Dementia (Semantic Dementia) 11/2023
1	Proteostasis Deficiencies 01/2023
1	Alzheimer Disease (Alzheimer's Disease) 01/2023
1	Huntington Disease (Huntington's Disease) 01/2023
1	Disease Progression 01/2019
1	REM Sleep Behavior Disorder 10/2018
1	Corticobasal Degeneration 10/2017
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Phenylketonurias (Phenylketonuria) 01/2017
1	Vascular Diseases (Vascular Disease) 01/2017
1	Bradycardia 03/2015
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2014
1	Inflammation (Inflammations) 01/2014

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 11/2023 - 04/2013
4	SynucleinsIBA 01/2021 - 02/2014
3	Phosphotransferases (Kinase)IBA 01/2023 - 04/2015
3	AutoantibodiesIBA 01/2014 - 04/2013
2	ProgranulinsIBA 11/2023 - 02/2023
2	Glucosylceramidase (Glucocerebrosidase)IBA 01/2023 - 03/2016
2	Transcription Factors (Transcription Factor)IBA 01/2023 - 01/2021
2	Leucine (L-Leucine)FDA Link 01/2023 - 04/2015
2	Glucose (Dextrose)FDA LinkGeneric 03/2019 - 10/2018
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 01/2017 - 05/2015
1	Adenosine Triphosphatases (ATPase)IBA 11/2023
1	CathepsinsIBA 11/2023
1	Glycoproteins (Glycoprotein)IBA 11/2023
1	HydrolasesIBA 11/2023
1	Adenylate KinaseIBA 01/2023
1	protein kinase DIBA 01/2023
1	Chloroquine (Aralen)FDA LinkGeneric 01/2023
1	Protein AggregatesIBA 01/2023
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	RE1-silencing transcription factorIBA 01/2021
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2019
1	Chemokine ReceptorsIBA 10/2018
1	Superoxide DismutaseIBA 10/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2018
1	AntioxidantsIBA 10/2018
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2017
1	EnzymesIBA 01/2017
1	Superoxides (Superoxide)IBA 01/2017
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2016
1	NeurotoxinsIBA 11/2015
1	Levodopa (L Dopa)FDA LinkGeneric 03/2015
1	sapropterin (tetrahydrobiopterin)FDA Link 02/2014
1	Free RadicalsIBA 01/2014
1	NitrogenIBA 01/2014
1	SugarsIBA 01/2014
1	LipidsIBA 01/2014
1	Collagen Type II (Type II Collagen)IBA 01/2014
1	ChlorineIBA 01/2014
1	AutoantigensIBA 01/2014
1	Rheumatoid FactorIBA 01/2014
1	Oxygen (Dioxygen)IBA 01/2014

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2017