Nancy Ratner Selected Research

Mitogens

1/2023

Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage.

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Nancy Ratner Research Topics

Disease

55	Neoplasms (Cancer) 05/2024 - 02/2002
29	Neurofibrosarcoma (MPNST) 03/2024 - 01/2005
29	Neurofibroma 01/2023 - 12/2003
21	Neurofibromatosis 1 (Neurofibromatosis Type I) 10/2023 - 01/2004
12	Plexiform Neurofibroma 03/2024 - 02/2012
12	Neurofibromatoses (Neurofibromatosis) 01/2021 - 11/2002
9	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 10/2012
7	Carcinogenesis 01/2019 - 03/2003
5	Neurilemmoma (Schwannoma) 01/2020 - 02/2002
4	Glioblastoma (Glioblastoma Multiforme) 11/2018 - 01/2018
3	Fibrosis (Cirrhosis) 07/2020 - 05/2006
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 12/2004
3	Neurofibromatosis 2 (Neurofibromatosis Type II) 01/2019 - 02/2002
3	Schwannomatosis 01/2018 - 03/2013
3	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 09/2014 - 01/2012
2	Neoplasm Metastasis (Metastasis) 01/2023 - 03/2006
2	Glioma (Gliomas) 01/2021 - 01/2018
2	Pain (Aches) 01/2021 - 01/2021
2	Neuroblastoma 03/2017 - 01/2009
2	Peripheral Nervous System Neoplasms 01/2013 - 05/2006
1	Hypersensitivity (Allergy) 01/2024
1	Neuralgia (Stump Neuralgia) 01/2024
1	Ependymoma 01/2019
1	Meningioma (Meningiomas) 01/2019
1	Necrosis 01/2019
1	Melanoma (Melanoma, Malignant) 10/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2018
1	Ovarian Neoplasms (Ovarian Cancer) 03/2018

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2002
12	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 05/2024 - 01/2013
10	ErbB Receptors (EGF Receptor)IBA 07/2014 - 03/2003
9	Neurofibromin 1 (Neurofibromin)IBA 01/2020 - 01/2004
6	CateninsIBA 03/2021 - 03/2013
6	Small Interfering RNA (siRNA)IBA 01/2021 - 03/2006
6	Guanosine Triphosphate (GTP)IBA 07/2020 - 11/2002
5	Biomarkers (Surrogate Marker)IBA 01/2023 - 03/2006
5	Neurofibromin 2 (Merlin)IBA 01/2023 - 02/2002
5	CytokinesIBA 01/2023 - 02/2016
4	Mitogen-Activated Protein KinasesIBA 01/2023 - 01/2015
4	AZD 6244IBA 01/2023 - 12/2016
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 11/2008
3	LigandsIBA 01/2021 - 10/2012
3	mirdametinibIBA 01/2021 - 01/2013
3	Aurora Kinase AIBA 01/2020 - 09/2012
3	Adenylate KinaseIBA 11/2018 - 01/2018
3	Everolimus FDA Link 03/2014 - 05/2008
3	CollagenIBA 08/2007 - 01/2005
2	CalciumIBA 01/2024 - 01/2023
2	Messenger RNA (mRNA)IBA 01/2024 - 10/2018
2	RNA (Ribonucleic Acid)IBA 01/2022 - 07/2016
2	Cyclin-Dependent Kinase Inhibitor p16IBA 11/2020 - 03/2006
2	Aurora KinasesIBA 01/2020 - 09/2012
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2019 - 05/2006
2	Protein Isoforms (Isoforms)IBA 01/2018 - 02/2002
2	MLN 8237IBA 03/2017 - 09/2012
2	Conditioned Culture MediaIBA 01/2017 - 10/2010
2	LipidsIBA 12/2015 - 04/2004
2	ras GTPase-Activating Proteins (ras-GAP)IBA 10/2015 - 01/2006
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 07/2012 - 01/2012
2	TensinsIBA 07/2012 - 01/2012
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2008 - 02/2007
2	OligonucleotidesIBA 03/2006 - 12/2004
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2006 - 01/2004
1	Synthetic DrugsIBA 03/2024
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2024
1	AntibodiesIBA 01/2024
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2023
1	EndoglinIBA 01/2023
1	Neutralizing AntibodiesIBA 01/2023
1	Oncogene Proteins (Oncogene Protein)IBA 01/2023
1	carotuximabIBA 01/2023
1	MitogensIBA 01/2023
1	BI-3406IBA 01/2023
1	Guanosine Diphosphate (GDP)IBA 01/2023
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022
1	Angiogenesis InhibitorsIBA 01/2022
1	Purinergic AgonistsIBA 01/2021
1	ArrestinIBA 01/2021
1	Peptide Nucleic AcidsIBA 01/2021
1	Purinergic Receptors (Receptors, Purine)IBA 01/2021
1	diphosphoric acid (pyrophosphoric acid)IBA 11/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020
1	Cytostatic AgentsIBA 01/2020
1	Polo-Like Kinase 1IBA 01/2020
1	CXCR3 ReceptorsIBA 02/2019
1	Chemokine CXCL10IBA 02/2019
1	FLLL 32IBA 01/2019
1	Myelin ProteinsIBA 01/2019
1	Dual-Specificity PhosphatasesIBA 01/2019
1	Core Binding Factors (Core-Binding Factor)IBA 01/2019
1	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 11/2018
1	Superoxides (Superoxide)IBA 03/2018

Therapy/Procedure

36	Therapeutics 03/2024 - 12/2003
5	Drug Therapy (Chemotherapy) 01/2020 - 03/2006
3	Transplantation 11/2020 - 03/2016
2	Immunotherapy 10/2018 - 10/2017
1	Cell Transplantation 01/2023
1	Precision Medicine 01/2021