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George Poulogiannis Selected Research

Neoplasms (Cancer)

11/2023Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer.
1/2020Reprogramming of fatty acid metabolism in cancer.
1/2018Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer.
3/2017PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
1/2017PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN.
5/2016Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.
4/2015Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
11/2013Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
6/2013IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.
5/2013The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
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George Poulogiannis Research Topics

Disease

16Neoplasms (Cancer)
11/2023 - 08/2010
6Breast Neoplasms (Breast Cancer)
11/2023 - 11/2013
6Neoplasm Metastasis (Metastasis)
01/2020 - 10/2009
6Adenoma (Adenomas)
02/2014 - 10/2009
4Colorectal Neoplasms (Colorectal Cancer)
02/2014 - 02/2010
2Carcinogenesis
01/2018 - 06/2010
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
01/2016
1Melanoma (Melanoma, Malignant)
04/2015
1Ovarian Neoplasms (Ovarian Cancer)
04/2015
1Carcinoma (Carcinomatosis)
06/2013
1Hypoxia (Hypoxemia)
02/2013
1Disease Progression
02/2012
1Lung Neoplasms (Lung Cancer)
12/2011
1Chromosomal Instability (Chromosome Stability)
02/2011
1Parkinsonian Disorders (Parkinsonism)
08/2010
1Prostatic Intraepithelial Neoplasia
06/2010
1Microsatellite Instability
01/2010
1T-Cell Lymphoma (Lymphoma, T Cell)
10/2009

Drug/Important Bio-Agent (IBA)

6Proteins (Proteins, Gene)FDA Link
01/2016 - 07/2011
4DNA (Deoxyribonucleic Acid)IBA
02/2012 - 01/2010
3Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2017 - 06/2010
3Dimenhydrinate (DMH)FDA LinkGeneric
02/2014 - 04/2010
3CarcinogensIBA
02/2014 - 04/2010
3Protein Isoforms (Isoforms)IBA
07/2011 - 04/2010
2Transcription Factors (Transcription Factor)IBA
11/2023 - 08/2012
2Fatty Acids (Saturated Fatty Acids)IBA
01/2020 - 01/2019
2Phosphatidylinositols (Phosphatidylinositol)IBA
01/2018 - 11/2013
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2018 - 03/2017
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2018 - 12/2011
2AsparagineIBA
01/2018 - 01/2018
2TensinsIBA
01/2017 - 06/2010
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2017 - 08/2010
2Biomarkers (Surrogate Marker)IBA
04/2015 - 02/2013
2A-Form DNA (A-DNA)IBA
04/2015 - 02/2010
2Phosphotransferases (Kinase)IBA
02/2014 - 11/2013
2Mechanistic Target of Rapamycin Complex 1IBA
05/2013 - 06/2011
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2011 - 10/2009
2GastrinsIBA
07/2011 - 10/2009
1Coenzyme A (CoA)IBA
11/2023
1Pantothenic Acid (Calcium Pantothenate)FDA Link
11/2023
1VitaminsIBA
11/2023
1Adenosine Triphosphate (ATP)IBA
01/2020
1Aldo-Keto ReductasesIBA
01/2019
1Asparaginase (Elspar)FDA Link
01/2018
1NexusIBA
01/2018
1Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA
01/2018
1MTOR InhibitorsIBA
03/2017
1ProteomeIBA
05/2016
1Poly(ADP-ribose) Polymerase InhibitorsIBA
04/2015
1LipidsIBA
04/2015
1phosphatidylinositol-3,4-bisphosphate 4-phosphataseIBA
04/2015
1RNA (Ribonucleic Acid)IBA
02/2014
1Mitogen-Activated Protein KinasesIBA
02/2014
1phosphatidylinositol 5-phosphateIBA
11/2013
1PlasticsIBA
11/2013
1Messenger RNA (mRNA)IBA
06/2013
1Small Interfering RNA (siRNA)IBA
02/2013
1Tyrosine (L-Tyrosine)FDA Link
02/2013
1TEA Domain Transcription FactorsIBA
08/2012
1Pyruvate KinaseIBA
12/2011
1EnzymesIBA
12/2011
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
06/2011
1Caspase 3 (Caspase-3)IBA
02/2011
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
06/2010
11,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA
04/2010
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
10/2009
1beta-NaphthoflavoneIBA
10/2009
1PPAR deltaIBA
10/2009
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
10/2009
1Protein Phosphatase 1IBA
10/2009
1Matrix Metalloproteinase 7 (Matrilysin)IBA
10/2009

Therapy/Procedure

2Therapeutics
01/2018 - 11/2017
1Diet Therapy (Therapy, Diet)
11/2023