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Warren S Pear Selected Research

Therapeutics

1/2022EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.
11/2014Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
10/2014Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.
4/2013Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration.
1/2011Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.
7/2010HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice.
1/2008Notch signaling in leukemia.
12/2005Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

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Warren S Pear Research Topics

Disease

13Neoplasms (Cancer)
10/2022 - 12/2002
9Leukemia
11/2017 - 12/2005
7Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2022 - 11/2004
6Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2022 - 01/2003
4BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
09/2003 - 04/2002
3Genetic Translocation (Chromosomal Translocation)
07/2010 - 06/2002
3T-Cell Lymphoma (Lymphoma, T Cell)
07/2010 - 05/2006
3Lymphoma (Lymphomas)
01/2008 - 11/2004
2Carcinogenesis
10/2022 - 10/2015
2Triple Negative Breast Neoplasms
01/2019 - 10/2014
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2010 - 11/2006
1Lymphopenia (Lymphocytopenia)
01/2022
1Mite Infestations (Mange)
10/2020
1Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
10/2020
1Ulcerative Colitis
10/2020
1Persistent Infection
01/2020
1Wounds and Injuries (Trauma)
01/2019
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2019
1Cicatrix (Scar)
01/2017
1Adenoid Cystic Carcinoma (Cylindroma)
10/2014
1Muscular Dystrophies (Muscular Dystrophy)
04/2013
1Hyperplasia
02/2013
1Inflammation (Inflammations)
02/2013
1Metaplasia
02/2013
1Graft vs Host Disease (Graft-Versus-Host Disease)
01/2011
1Hematologic Neoplasms (Hematological Malignancy)
01/2011
1Myeloid Leukemia (Leukemia, Myelocytic)
08/2010
1Disease Progression
07/2010
1Tuberous Sclerosis (Bourneville's Disease)
01/2010
1Melanoma (Melanoma, Malignant)
07/2009
1Vascular Remodeling
02/2008
1Congenital Heart Defects (Congenital Heart Defect)
02/2008
1Basal Cell Carcinoma (Rodent Ulcer)
08/2006
1Hypoxia (Hypoxemia)
12/2005
1Philadelphia Chromosome
12/2002
1Blast Crisis (Blast Phase)
06/2002
1Hemorrhage
03/2002

Drug/Important Bio-Agent (IBA)

4LigandsIBA
01/2022 - 12/2005
4Transcription Factors (Transcription Factor)IBA
01/2019 - 05/2006
4Proteins (Proteins, Gene)FDA Link
11/2017 - 06/2002
4Notch ReceptorsIBA
01/2011 - 01/2003
3ChromatinIBA
01/2022 - 01/2014
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2016 - 11/2004
2PlasticsIBA
01/2022 - 01/2017
2CCAAT-Enhancer-Binding Protein-alphaIBA
08/2010 - 11/2006
2T-Cell Antigen Receptors (T-Cell Receptor)IBA
07/2010 - 05/2006
2Lysine (L-Lysine)FDA Link
02/2009 - 01/2006
2Histones (Histone)IBA
02/2009 - 01/2006
2MethyltransferasesIBA
02/2009 - 01/2006
2Notch1 ReceptorIBA
01/2008 - 11/2004
2Fibronectins (Fibronectin)IBA
09/2003 - 06/2002
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2002 - 04/2002
1ArginaseIBA
10/2022
1CytokinesIBA
10/2022
1Dextran SulfateIBA
10/2020
1AntigensIBA
01/2020
1RNA (Ribonucleic Acid)IBA
01/2019
1Biomarkers (Surrogate Marker)IBA
10/2014
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
09/2014
1Complementary DNA (cDNA)IBA
03/2013
1Mucin 5ACIBA
02/2013
1Recombinases (Recombinase)IBA
12/2010
1Messenger RNA (mRNA)IBA
08/2010
1Carrier Proteins (Binding Protein)IBA
07/2010
1ClathrinIBA
07/2010
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
07/2010
1TensinsIBA
07/2010
1IronIBA
07/2010
1trans-sodium crocetinate (crocetin)IBA
01/2010
1Mitogen-Activated Protein KinasesIBA
07/2009
1Staphylococcal Protein A (Protein A)IBA
02/2009
1CarcinogensIBA
09/2008
1TCF Transcription FactorsIBA
10/2007
1Oxygen (Dioxygen)IBA
12/2005
1A 7 (A-7)IBA
11/2004
1Peptide Hydrolases (Proteases)FDA Link
11/2004
1PresenilinsIBA
01/2003
1Imatinib Mesylate (Gleevec)FDA Link
06/2002
1PhosphoproteinsIBA
03/2002

Therapy/Procedure

8Therapeutics
01/2022 - 12/2005
1Immunotherapy
10/2022
1Drug Tapering
10/2020
1Hematopoietic Stem Cell Transplantation
01/2011
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
09/2003