Lefkothea C Papadopoulou Selected Research

Electron Transport Complex IV (Cytochrome c Oxidase)

1/2024	Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K‑562 and colorectal HCT‑116 cancer cells.
1/2023	Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency.
12/2021	Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders.
6/2010	Intracellular delivery of full length recombinant human mitochondrial L-Sco2 protein into the mitochondria of permanent cell lines and SCO2 deficient patient's primary cells.

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Lefkothea C Papadopoulou Research Topics

Disease

6	Neoplasms (Cancer) 01/2024 - 03/2002
6	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 03/2002
4	Cytochrome-c Oxidase Deficiency 01/2023 - 06/2010
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 12/2020
3	Thalassemia 12/2021 - 12/2018
3	Leukemia 06/2014 - 03/2002
2	Hemoglobinopathies 07/2021 - 12/2018
1	Hypoxia (Hypoxemia) 01/2024
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2024
1	Acute Erythroblastic Leukemia (Erythroleukemia) 07/2021
1	Protein Deficiency 12/2018
1	Hematologic Diseases (Blood Diseases) 01/2013
1	Anemia 08/2006
1	Acute Intermittent Porphyria (Porphyria, Acute) 08/2006
1	Hematologic Neoplasms (Hematological Malignancy) 08/2006

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2010
4	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2024 - 06/2010
4	Messenger RNA (mRNA)IBA 11/2023 - 12/2021
3	Recombinant ProteinsIBA 01/2023 - 06/2010
2	FrataxinIBA 01/2024 - 06/2014
2	Imatinib Mesylate (Gleevec)FDA Link 01/2024 - 06/2014
2	Heme (Haem)IBA 01/2024 - 08/2006
2	Chimeric Antigen ReceptorsIBA 11/2022 - 01/2020
2	GlobinsIBA 07/2021 - 12/2018
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 06/2014 - 11/2011
1	Biomarkers (Surrogate Marker)IBA 01/2024
1	Lactate Dehydrogenase 5IBA 01/2024
1	Oxidoreductases (Dehydrogenase)IBA 01/2024
1	Pyruvate KinaseIBA 01/2024
1	Stem Cell FactorIBA 01/2024
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2024
1	ErbB Receptors (EGF Receptor)IBA 11/2022
1	Surface Antigens (Surface Antigen)IBA 11/2022
1	hemoglobin Bart'sIBA 07/2021
1	EnzymesIBA 01/2013
1	Carrier Proteins (Binding Protein)IBA 01/2013
1	Oxygen (Dioxygen)IBA 01/2013
1	Recombinant DNA (Recombinant DNA Research)IBA 11/2011
1	Mitochondrial DNA (mtDNA)IBA 03/2002

Therapy/Procedure

8	Therapeutics 11/2023 - 11/2011
4	Immunotherapy 11/2023 - 01/2018
1	Drug Therapy (Chemotherapy) 01/2024