Pál Pacher Selected Research

Enzymes

1/2020	Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system.
8/2013	Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro.
5/2013	Modulating the endocannabinoid system in human health and disease--successes and failures.
4/2012	Interplay of cannabinoid 2 (CB2) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration.
1/2011	Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury.
6/2010	CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model.
2/2010	Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.
3/2009	Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.
12/2006	Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
2/2006	Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.

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Pál Pacher Research Topics

Disease

49	Inflammation (Inflammations) 01/2022 - 01/2002
21	Sepsis (Septicemia) 09/2023 - 04/2002
19	Heart Failure 01/2023 - 09/2002
16	Neoplasms (Cancer) 01/2019 - 04/2004
15	Atherosclerosis 01/2023 - 11/2004
14	Reperfusion Injury 11/2021 - 01/2002
12	Shock 03/2012 - 03/2002
11	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 01/2004
10	Obesity 11/2017 - 05/2005
9	Ischemia 01/2023 - 01/2002
9	Hypertension (High Blood Pressure) 01/2023 - 01/2004
9	Cardiomyopathies (Cardiomyopathy) 01/2017 - 10/2005
8	Cardiotoxicity 11/2015 - 02/2003
6	Myocardial Infarction 01/2023 - 07/2005
6	Pneumonia (Pneumonitis) 12/2021 - 02/2002
6	Hypoxia (Hypoxemia) 04/2016 - 07/2004
6	Fibrosis (Cirrhosis) 01/2015 - 04/2008
6	Hypotension (Low Blood Pressure) 01/2013 - 11/2003
6	Stroke (Strokes) 09/2012 - 09/2002
5	Diabetic Cardiomyopathies 02/2015 - 02/2006
5	Necrosis 08/2013 - 04/2002
5	Pain (Aches) 05/2013 - 05/2007
4	Weight Gain 04/2024 - 10/2005
4	Asthma (Bronchial Asthma) 01/2019 - 03/2004
4	Multiple Sclerosis 01/2019 - 09/2006
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 04/2015 - 10/2002
4	Hyperglycemia 02/2015 - 01/2005
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2013 - 09/2006
4	Diabetes Complications 02/2012 - 01/2005
4	Liver Cirrhosis (Hepatic Cirrhosis) 08/2009 - 07/2004
3	Infections 01/2019 - 10/2007
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019 - 06/2007
3	Lung Injury 09/2013 - 02/2003
3	Arthritis (Polyarthritis) 09/2008 - 10/2002
3	Body Weight (Weight, Body) 05/2008 - 04/2003

Drug/Important Bio-Agent (IBA)

32	EndocannabinoidsIBA 01/2020 - 07/2004
23	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2015 - 01/2002
22	CannabinoidsIBA 11/2015 - 11/2003
19	EnzymesIBA 01/2020 - 03/2002
18	Adenosine (Adenocard)FDA LinkGeneric 09/2023 - 04/2003
12	Purinergic P1 Receptors (Adenosine Receptor)IBA 11/2017 - 10/2005
12	CytokinesIBA 10/2011 - 02/2002
11	anandamide (arachidonylethanolamide)IBA 01/2020 - 07/2004
11	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2015 - 02/2003
10	Superoxides (Superoxide)IBA 02/2015 - 10/2002
10	NitrogenIBA 01/2011 - 12/2002
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 02/2002
9	Poly(ADP-ribose) Polymerase InhibitorsIBA 11/2011 - 01/2002
9	Peroxynitrous Acid (Peroxynitrite)IBA 05/2009 - 10/2002
8	Antineoplastic Agents (Antineoplastics)IBA 01/2013 - 02/2003
8	Cisplatin (Platino)FDA LinkGeneric 07/2012 - 03/2009
8	Oxygen (Dioxygen)IBA 01/2011 - 12/2002
8	Oxidants (Oxidizing Agents)IBA 03/2005 - 01/2002
7	LipidsIBA 01/2020 - 12/2008
7	Cannabinoid Receptors (Cannabinoid Receptor)IBA 04/2016 - 06/2005
7	3-nitrotyrosineIBA 01/2015 - 03/2009
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2009 - 02/2002
6	LipopolysaccharidesIBA 12/2021 - 01/2002
6	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 07/2005
6	CannabidiolIBA 01/2015 - 03/2009
6	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 01/2013 - 11/2003
6	ChemokinesIBA 05/2007 - 02/2002
5	Adenosine Triphosphate (ATP)IBA 09/2023 - 10/2003
5	LigandsIBA 01/2023 - 05/2005
5	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 12/2010
5	Messenger RNA (mRNA)IBA 01/2015 - 07/2004
5	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2015 - 04/2004
5	Poly (ADP-Ribose) Polymerase-1IBA 08/2013 - 02/2002
5	AntioxidantsIBA 08/2013 - 03/2009
5	Poly Adenosine Diphosphate RiboseIBA 12/2010 - 04/2002
5	N- (oxo- 5,6- dihydrophenanthridin- 2- yl)- N,N- dimethylacetamide hydrochlorideIBA 04/2004 - 01/2002
4	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017 - 06/2011
4	CB2 Cannabinoid ReceptorIBA 02/2016 - 08/2007
4	Proteins (Proteins, Gene)FDA Link 01/2015 - 02/2002
4	Peroxidase (Myeloperoxidase)IBA 10/2011 - 02/2002
4	Interleukin-10 (Interleukin 10)IBA 10/2007 - 04/2002
3	Interleukin-6 (Interleukin 6)IBA 12/2021 - 02/2002
3	Inosine FDA Link 11/2021 - 04/2002
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020 - 07/2010
3	Purinergic Receptors (Receptors, Purine)IBA 01/2019 - 01/2015
3	Insulin (Novolin)FDA Link 11/2017 - 06/2009
3	Streptozocin (Streptozotocin)FDA Link 10/2016 - 10/2002
3	LeptinIBA 10/2016 - 06/2009
3	SaltsIBA 09/2015 - 12/2002
3	Protein Kinase CIBA 02/2015 - 01/2005
3	polyolIBA 02/2015 - 01/2005
3	Transforming Growth Factor beta (TGF-beta)IBA 01/2015 - 11/2008
3	SodiumIBA 01/2015 - 04/2003
3	Fibronectins (Fibronectin)IBA 01/2015 - 08/2009
3	DNA (Deoxyribonucleic Acid)IBA 08/2013 - 01/2004
3	JNK Mitogen-Activated Protein KinasesIBA 03/2012 - 06/2010
3	CollagenIBA 12/2010 - 10/2002
3	Caspase 3 (Caspase-3)IBA 12/2010 - 03/2009
3	CreatinineIBA 06/2010 - 03/2009
3	Ethanol (Ethyl Alcohol)IBA 06/2009 - 05/2005

Therapy/Procedure

12	Ligation 01/2022 - 04/2002
10	Therapeutics 01/2018 - 04/2002
9	Punctures 01/2022 - 04/2002
4	Drug Therapy (Chemotherapy) 01/2020 - 03/2009
3	Heart Transplantation (Grafting, Heart) 02/2006 - 01/2002