Makoto Otsu Selected Research

Immunotherapy

4/2009	T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.
2/2006	Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap.

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Makoto Otsu Research Topics

Disease

9	Neoplasms (Cancer) 01/2017 - 02/2006
5	Severe combined immunodeficiency due to adenosine deaminase deficiency 12/2021 - 02/2002
3	Teratoma (Teratoid Tumor) 01/2015 - 11/2010
2	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2021 - 08/2002
2	Inflammation (Inflammations) 01/2017 - 11/2013
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2016 - 05/2014
2	Mucopolysaccharidosis II (Hunter Syndrome) 11/2016 - 03/2015
2	Leukemia 07/2013 - 06/2012
1	Chromosomal Instability (Chromosome Stability) 08/2023
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2023
1	Autoimmune Diseases (Autoimmune Disease) 01/2023
1	Osteoporosis 10/2018
1	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 10/2018
1	Chronic Granulomatous Disease 10/2016
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 01/2015
1	Liver Diseases (Liver Disease) 12/2014
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 11/2014
1	Primary Myelofibrosis (Myelosclerosis) 09/2014
1	Glycogen Storage Disease Type II (Pompe's Disease) 05/2014
1	Insulin Resistance 11/2013
1	Bone Marrow Failure Disorders 09/2013
1	Congenital amegakaryocytic thrombocytopenia 09/2013
1	Pancytopenia 09/2013
1	Leukopenia 09/2013
1	Thrombocytopenia (Thrombopenia) 09/2013
1	Anemia 09/2013
1	Graft vs Host Disease (Graft-Versus-Host Disease) 07/2013
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2012
1	Thrombosis (Thrombus) 02/2012
1	Fabry Disease (Fabry's Disease) 05/2011
1	Primary Immunodeficiency Diseases 01/2010
1	Vesicular Stomatitis 09/2008
1	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 01/2002

Drug/Important Bio-Agent (IBA)

4	Adenosine DeaminaseIBA 12/2021 - 02/2002
4	Proteins (Proteins, Gene)FDA Link 07/2011 - 09/2008
2	GlycosaminoglycansIBA 11/2016 - 03/2015
2	Complementary DNA (cDNA)IBA 10/2016 - 09/2008
2	Codon (Codons)IBA 10/2016 - 09/2008
2	CytokinesIBA 09/2014 - 08/2009
2	AntigensIBA 07/2011 - 02/2006
1	ChromatinIBA 08/2023
1	InterferonsIBA 01/2023
1	Diphosphonates (Bisphosphonates)IBA 10/2018
1	Clodronic Acid (Clodronate)IBA 10/2018
1	Heparitin Sulfate (Heparan Sulfate)IBA 11/2016
1	Iduronic Acid (Iduronate)IBA 11/2016
1	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 01/2015
1	SphingosineIBA 11/2014
1	Interleukin-8 (Interleukin 8)IBA 09/2014
1	Messenger RNA (mRNA)IBA 09/2014
1	GlycogenIBA 05/2014
1	GlucosidasesIBA 05/2014
1	AcidsIBA 05/2014
1	Interleukin-10 (Interleukin 10)IBA 11/2013
1	CohesinsIBA 10/2013
1	Thrombopoietin ReceptorsIBA 09/2013
1	Imatinib Mesylate (Gleevec)FDA Link 06/2012
1	TalinIBA 02/2012
1	IntegrinsIBA 02/2012
1	Acetylcysteine (Siran)FDA LinkGeneric 02/2012
1	Estrogen ReceptorsIBA 07/2011
1	GlycolipidsIBA 05/2011
1	GalactosidasesIBA 05/2011
1	EnzymesIBA 05/2011
1	Interleukin-2 (IL2)IBA 04/2009
1	Peptides (Polypeptides)IBA 02/2006
1	ZAP-70 Protein-Tyrosine Kinase (ZAP 70 Protein Tyrosine Kinase)IBA 08/2002

Therapy/Procedure

4	Transplantation 01/2017 - 09/2008
4	Therapeutics 12/2014 - 01/2002
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/2016 - 05/2011
2	Immunotherapy 04/2009 - 02/2006
1	Enzyme Replacement Therapy 12/2015
1	Intravenous Injections 07/2013
1	Hematopoietic Stem Cell Transplantation 01/2010
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2010