Motohiko Oshima Selected Research

Hepatocellular Carcinoma (Hepatoma)

11/2021	EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma.
3/2017	Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.
1/2014	Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.
1/2013	Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells.

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Motohiko Oshima Research Topics

Disease

16	Neoplasms (Cancer) 01/2023 - 01/2013
8	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021 - 05/2014
4	Multiple Myeloma 01/2023 - 08/2017
4	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 01/2013
4	Hematologic Neoplasms (Hematological Malignancy) 08/2019 - 10/2017
3	POEMS Syndrome (Syndrome, POEMS) 01/2023 - 01/2019
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 09/2015
2	Anemia 01/2023 - 06/2017
2	Primary Myelofibrosis (Myelosclerosis) 01/2022 - 06/2017
1	Acute Promyelocytic Leukemia 12/2022
1	Leukemia 12/2022
1	Plasma Cell Neoplasms 10/2022
1	Infections 01/2022
1	Thrombocytopenia (Thrombopenia) 12/2021
1	Liver Neoplasms (Liver Cancer) 11/2021
1	Hypoxia (Hypoxemia) 10/2021
1	Alopecia (Baldness) 01/2021
1	Heart Failure 01/2020
1	Breast Neoplasms (Breast Cancer) 02/2019
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2018
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018
1	Prostatic Neoplasms (Prostate Cancer) 08/2017
1	Splenomegaly 06/2017
1	Diabetes Mellitus 01/2013
1	Hypersensitivity (Allergy) 12/2009
1	Septic Shock (Toxic Shock Syndrome) 12/2009

Drug/Important Bio-Agent (IBA)

6	Polycomb Repressive Complex 2IBA 01/2022 - 06/2014
5	RNA (Ribonucleic Acid)IBA 01/2023 - 08/2017
3	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2019
3	ChromatinIBA 12/2022 - 01/2019
3	Co-Repressor ProteinsIBA 10/2019 - 10/2017
2	Histones (Histone)IBA 01/2023 - 01/2022
2	UNC1999IBA 11/2021 - 08/2017
2	Sorafenib (BAY 43-9006)FDA Link 11/2021 - 01/2013
2	PTC596IBA 01/2021 - 12/2020
2	Proteasome InhibitorsIBA 01/2021 - 08/2017
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 02/2019
2	Messenger RNA (mRNA)IBA 06/2017 - 05/2014
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2022
1	Amino Acids FDA Link 10/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	ChemokinesIBA 10/2021
1	Pancreatic Elastase (Elastase)IBA 10/2021
1	emvododstatIBA 01/2021
1	LipidsIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Dihydroorotate DehydrogenaseIBA 01/2021
1	TubulinIBA 12/2020
1	PTC-028IBA 12/2020
1	Tubulin ModulatorsIBA 12/2020
1	Estrogen ReceptorsIBA 02/2019
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 02/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 02/2019
1	EnzymesIBA 11/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2017
1	BIX 01294IBA 03/2017
1	Histone-Lysine N-MethyltransferaseIBA 03/2017
1	Double-Stranded RNA (RNA, Double Stranded)IBA 09/2015
1	eIF-2 Kinase (eIF 2 Kinase)IBA 09/2015
1	Disulfiram (Antabuse)FDA Link 01/2014
1	Fluorouracil (Carac)FDA LinkGeneric 01/2014
1	Aldehyde DehydrogenaseIBA 01/2014
1	Metformin (Glucophage)FDA LinkGeneric 01/2013
1	Epithelial Cell Adhesion MoleculeIBA 01/2013
1	TOR Serine-Threonine KinasesIBA 01/2013
1	AMP-Activated Protein KinasesIBA 01/2013
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 12/2009
1	LipopolysaccharidesIBA 12/2009

Therapy/Procedure

2	Therapeutics 12/2022 - 08/2017
1	Radiotherapy 01/2022
1	Platelet Transfusion (Blood Platelet Transfusions) 12/2021
1	Transplantation 01/2019
1	Heterologous Transplantation (Xenotransplantation) 01/2013