Peter J M Openshaw Selected Research

Cytokines

12/2023	Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
11/2023	A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.
11/2022	Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
1/2020	Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities.
1/2016	The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells.
6/2014	Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection.
1/2014	Immunity to RSV in Early-Life.
5/2010	Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection.
4/2010	Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells.
12/2009	IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection.

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Peter J M Openshaw Research Topics

Disease

33	COVID-19 09/2024 - 01/2020
31	Infections 12/2023 - 01/2002
17	Respiratory Syncytial Virus Infections 01/2024 - 11/2002
14	Human Influenza (Influenza) 12/2023 - 01/2002
9	Virus Diseases (Viral Diseases) 01/2023 - 06/2004
8	Inflammation (Inflammations) 12/2023 - 06/2003
8	Bronchiolitis 01/2022 - 07/2005
8	Lung Diseases (Lung Disease) 01/2021 - 10/2004
6	Asthma (Bronchial Asthma) 01/2022 - 12/2004
6	Pneumonia (Pneumonitis) 01/2020 - 10/2004
5	Critical Illness (Critically Ill) 01/2023 - 01/2020
5	Reinfection 01/2023 - 11/2002
4	Obesity 10/2023 - 04/2011
4	Weight Loss (Weight Reduction) 01/2014 - 11/2002
3	Neoplasms (Cancer) 04/2024 - 01/2023
3	Disease Progression 12/2023 - 04/2011
3	Hypersensitivity (Allergy) 01/2021 - 06/2003
3	Vaccinia 01/2009 - 11/2004
2	Heart Diseases (Heart Disease) 01/2023 - 04/2011
2	Coinfection 05/2022 - 05/2010
2	Chronic Obstructive Pulmonary Disease (COPD) 08/2012 - 04/2006
2	Eosinophilia 02/2008 - 06/2003
2	Paramyxoviridae Infections (Parainfluenza) 06/2004 - 01/2002
1	Post-Acute COVID-19 Syndrome 04/2024
1	Sepsis (Septicemia) 02/2024
1	Necrosis 11/2023
1	Brain Injuries (Brain Injury) 11/2022
1	Bell Palsy (Bell's Palsy) 11/2022
1	Edema (Dropsy) 11/2022
1	Asymptomatic Infections 01/2022
1	Cardiac Arrhythmias (Arrythmia) 01/2022
1	Hyperglycemia 01/2022
1	Heart Arrest (Cardiac Arrest) 01/2022
1	Heart Failure 01/2022
1	Stroke (Strokes) 01/2022
1	Ischemia 01/2022
1	Dementia (Dementias) 01/2022
1	Hypoxia (Hypoxemia) 10/2021
1	HIV Infections (HIV Infection) 10/2021

Drug/Important Bio-Agent (IBA)

18	VaccinesIBA 12/2023 - 01/2002
17	CytokinesIBA 12/2023 - 01/2002
13	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2004
10	Antiviral Agents (Antivirals)IBA 10/2023 - 01/2005
8	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2021
8	InterferonsIBA 10/2023 - 06/2014
5	ChemokinesIBA 12/2023 - 05/2006
5	Oxygen (Dioxygen)IBA 10/2023 - 08/2012
4	Immunoglobulin G (IgG)IBA 04/2024 - 12/2009
4	AntibodiesIBA 11/2023 - 01/2021
4	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2022 - 01/2021
4	Messenger RNA (mRNA)IBA 01/2018 - 07/2005
4	Interleukin-4 (Interleukin 4)IBA 01/2014 - 12/2007
4	Interferon-gamma (Interferon, gamma)IBA 04/2008 - 11/2002
3	Immunoglobulin A (IgA)IBA 09/2024 - 05/2015
3	Interleukin-5 (Interleukin 5)IBA 01/2014 - 06/2003
2	Influenza Vaccines (Influenza Vaccine)FDA Link 12/2023 - 03/2017
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2023 - 01/2020
2	Interleukin-17 (Interleukin 17)IBA 11/2023 - 12/2012
2	AntigensIBA 01/2023 - 06/2003
2	AutoantibodiesIBA 01/2023 - 11/2022
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2023 - 01/2022
2	Peptides (Polypeptides)IBA 01/2023 - 11/2020
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2020 - 01/2014
2	Neutralizing AntibodiesIBA 05/2015 - 04/2004
2	AllergensIBA 03/2014 - 06/2003
2	Liposomes (Liposome)IBA 01/2014 - 05/2008
2	Clodronic Acid (Clodronate)IBA 01/2014 - 05/2008
2	DNA (Deoxyribonucleic Acid)IBA 02/2008 - 10/2004
2	EpitopesIBA 10/2004 - 04/2004
1	Interleukin-2 (IL2)IBA 12/2023
1	Interleukin-10 (Interleukin 10)IBA 12/2023
1	Interleukin-23 (Interleukin 23)IBA 11/2023
1	Viral RNAIBA 11/2023
1	LeptinIBA 10/2023
1	Desmoglein 2IBA 01/2023
1	Complement C3b (C3bi)IBA 01/2023
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2023
1	Complement System Proteins (Complement)IBA 01/2023
1	DesmogleinsIBA 01/2023
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2023
1	remdesivirIBA 01/2023
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2023
1	Glial Fibrillary Acidic ProteinIBA 11/2022
1	Adenosine Monophosphate (AMP)IBA 11/2022
1	ProcalcitoninIBA 05/2022
1	Immunoglobulin M (IgM)IBA 01/2022
1	Subgenomic RNAIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	NucleoproteinsIBA 01/2022
1	Blood Glucose (Blood Sugar)IBA 01/2022
1	Ligases (Synthetase)IBA 10/2021
1	Ribonucleases (Ribonuclease)IBA 10/2021
1	hydroxide ionIBA 10/2021
1	Vitamin D FDA LinkGeneric 10/2021
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 07/2021

Therapy/Procedure

10	Critical Care (Surgical Intensive Care) 01/2023 - 01/2012
9	Therapeutics 04/2024 - 12/2004
4	Immunomodulation 02/2024 - 07/2005
2	Artificial Respiration (Mechanical Ventilation) 01/2021 - 01/2020
1	Perioperative Care 11/2022