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Tomohiro Okagawa Selected Research

Immune Checkpoint Proteins

9/2023Development of a high-affinity anti-bovine PD-1 rabbit-bovine chimeric antibody using an efficient selection and large production system.
1/2023Molecular characterization of feline immune checkpoint molecules and establishment of PD-L1 immunohistochemistry for feline tumors.
1/2023Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus.
1/2017A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.

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Tomohiro Okagawa Research Topics

Disease

13Disease Progression
09/2023 - 05/2012
11Neoplasms (Cancer)
06/2023 - 01/2014
9Deltaretrovirus Infections (BLV Infection)
01/2023 - 05/2012
8Persistent Infection
09/2023 - 05/2012
8Melanoma (Melanoma, Malignant)
06/2023 - 01/2016
7Infections
01/2020 - 05/2012
5Paratuberculosis (Johne's Disease)
10/2022 - 01/2016
3Marek Disease (Marek's Disease)
01/2024 - 11/2021
2Carcinogenesis
01/2024 - 11/2021
2Osteosarcoma (Osteogenic Sarcoma)
06/2023 - 01/2020
2Cattle Diseases (Bovine Diseases)
01/2022 - 07/2014
2Bacterial Infections (Bacterial Infection)
01/2020 - 01/2019
2Chronic Disease (Chronic Diseases)
10/2019 - 01/2017
1Listeriosis (Listeria Infection)
07/2023
1Necrosis
06/2023
1Respiratory Tract Infections (Respiratory Tract Infection)
03/2023
1Adenocarcinoma
01/2023
1Thrombocytopenia (Thrombopenia)
01/2023
1Diarrhea
01/2023
1Horse Diseases (Horse Disease)
01/2020
1Inflammation (Inflammations)
02/2019
1Virus Diseases (Viral Diseases)
01/2019
1Sarcoma (Soft Tissue Sarcoma)
01/2017
1Lymphocytosis
03/2016
1Renal Cell Carcinoma (Grawitz Tumor)
01/2016
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2016
1Lymphoma (Lymphomas)
08/2014
1Disease Resistance
08/2012

Drug/Important Bio-Agent (IBA)

10LigandsIBA
01/2023 - 05/2012
9B7-H1 AntigenIBA
06/2023 - 01/2014
6CytokinesIBA
01/2023 - 08/2012
6AntibodiesIBA
01/2023 - 01/2016
5Monoclonal AntibodiesIBA
07/2023 - 01/2017
5Immune Checkpoint InhibitorsIBA
06/2023 - 01/2016
5Dinoprostone (PGE2)FDA Link
01/2022 - 01/2018
4Immune Checkpoint ProteinsIBA
09/2023 - 01/2017
4AntigensIBA
10/2022 - 01/2014
3Proteins (Proteins, Gene)FDA Link
01/2024 - 03/2016
3Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2020 - 01/2018
2InterferonsIBA
06/2023 - 01/2023
2MucinsIBA
01/2023 - 05/2012
2Antiviral Agents (Antivirals)IBA
01/2023 - 01/2019
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2022 - 02/2019
2ProstaglandinsIBA
10/2022 - 01/2019
2Transforming Growth Factors (Transforming Growth Factor)IBA
01/2021 - 01/2020
2Blocking AntibodiesIBA
01/2018 - 01/2017
2Messenger RNA (mRNA)IBA
02/2015 - 05/2012
1Protein Isoforms (Isoforms)IBA
01/2024
1Complementary DNA (cDNA)IBA
07/2023
1CME-Carbodiimide (CMEC)IBA
06/2023
1Viral VaccinesIBA
03/2023
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2023
1Anti-Bacterial Agents (Antibiotics)IBA
01/2023
1CTLA-4 AntigenIBA
10/2022
1Biomarkers (Surrogate Marker)IBA
01/2022
1Estradiol (Delestrogen)FDA LinkGeneric
01/2022
1Interleukin-2 (IL2)IBA
12/2021
1Transcription Factors (Transcription Factor)IBA
11/2021
1Protein SIBA
11/2021
1Oncogene Proteins (Oncogene Protein)IBA
11/2021
1Toll-Like Receptors (Toll-Like Receptor)IBA
01/2021
1Transforming Growth Factor beta (TGF-beta)IBA
01/2021
1vesatolimodIBA
01/2021
1Interleukin-10 (Interleukin 10)IBA
01/2020
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
01/2019
1Meloxicam (Mobic)FDA LinkGeneric
01/2019
1Prostaglandin E Receptors (Prostaglandin E Receptor)IBA
01/2019
1Tuberculin (PPD)IBA
01/2018
1Interferon-gamma (Interferon, gamma)IBA
01/2018
1VaccinesIBA
06/2016
1PerforinIBA
03/2016
1Immunoglobulin M (IgM)IBA
08/2014
1Histocompatibility Antigens Class IIIBA
01/2013
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
05/2012

Therapy/Procedure

11Therapeutics
06/2023 - 07/2013
8Immunotherapy
01/2023 - 01/2016
1Radiotherapy
06/2023