Ina Oehme Selected Research

Neuroblastoma

1/2023	ERBB and P-glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P-glycoprotein.
1/2023	Evaluation of Antitumor and On-Target Activity of HDAC Inhibitors with the Zebrafish Embryo Xenograft Model.
7/2022	Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
1/2022	First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
9/2021	Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma.
1/2021	Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma.
10/2020	Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts.
1/2020	Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
12/2019	Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.
1/2019	The enzyme activity of histone deacetylase 8 is modulated by a redox-switch.

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Ina Oehme Research Topics

Disease

39	Neoplasms (Cancer) 04/2024 - 07/2008
22	Neuroblastoma 01/2023 - 07/2008
9	Medulloblastoma 01/2024 - 06/2010
3	Glioma (Gliomas) 04/2024 - 07/2010
3	Ependymoma 11/2012 - 03/2009
2	Astrocytoma (Pilocytic Astrocytoma) 01/2023 - 01/2019
2	Carcinogenesis 07/2015 - 01/2009
2	Carcinoma (Carcinomatosis) 05/2013 - 07/2008
1	Brain Neoplasms (Brain Tumor) 01/2023
1	Drug-Related Side Effects and Adverse Reactions 01/2023
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016
1	Colitis 12/2015
1	Intellectual Disability (Idiocy) 07/2015
1	Parasitic Diseases (Parasitic Disease) 07/2015
1	Lymphoma (Lymphomas) 08/2013
1	Hematologic Neoplasms (Hematological Malignancy) 08/2013
1	Hepatocellular Carcinoma (Hepatoma) 08/2013
1	Isochromosomes 12/2012
1	Pancreatic Neoplasms (Pancreatic Cancer) 06/2012
1	Disease Progression 03/2009
1	Neoplasm Metastasis (Metastasis) 03/2009
1	Chromosome Aberrations (Chromosome Abnormalities) 03/2009

Drug/Important Bio-Agent (IBA)

21	Histone Deacetylase InhibitorsIBA 01/2024 - 07/2008
15	Histone Deacetylases (Histone Deacetylase)IBA 01/2023 - 01/2009
4	IsoenzymesIBA 07/2022 - 07/2013
4	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2015
3	ZincIBA 01/2022 - 05/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 03/2009
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2020 - 07/2013
3	Messenger RNA (mRNA)IBA 12/2018 - 01/2009
3	Proteins (Proteins, Gene)FDA Link 07/2013 - 06/2010
2	Conditioned Culture MediaIBA 04/2024 - 01/2019
2	Drug CombinationsIBA 01/2024 - 10/2020
2	entinostat (MS 275)IBA 05/2023 - 01/2021
2	Mitogen-Activated Protein KinasesIBA 01/2023 - 01/2023
2	Vorinostat FDA Link 01/2021 - 11/2011
2	PCI 34051IBA 01/2020 - 12/2018
1	CytokinesIBA 04/2024
1	Adenosine Triphosphate (ATP)IBA 05/2023
1	ulixertinibIBA 01/2023
1	tariquidar (XR9576)IBA 01/2023
1	Histone Deacetylase 6IBA 01/2023
1	AfatinibIBA 01/2023
1	SenotherapeuticsIBA 01/2023
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2023
1	Trypan Blue FDA Link 01/2023
1	Vincristine (Oncovin)FDA LinkGeneric 01/2023
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2023
1	PolyaminesIBA 10/2022
1	Proteolysis Targeting ChimeraIBA 07/2022
1	sonidegibIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 09/2021
1	eprenetapoptIBA 09/2021
1	ChromatinIBA 01/2021
1	Chloroquine (Aralen)FDA LinkGeneric 01/2021
1	PanobinostatIBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	CrizotinibIBA 12/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2018
1	Differentiation AntigensIBA 01/2018
1	CaspasesIBA 01/2018
1	Antineoplastic Agents (Antineoplastics)IBA 01/2018
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 12/2015
1	Dextrans (Dextran)FDA Link 12/2015
1	EnzymesIBA 04/2015
1	Histone Deacetylase 2IBA 04/2015
1	LigandsIBA 08/2013
1	Cytotoxins (Cytolysins)IBA 07/2013
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 07/2013
1	MicroRNAs (MicroRNA)IBA 07/2013
1	Glial Fibrillary Acidic ProteinIBA 12/2012
1	NestinIBA 11/2012
1	Gemcitabine FDA Link 06/2012
1	belinostatIBA 06/2012
1	Sirolimus (Rapamycin)FDA Link 07/2010
1	Small Interfering RNA (siRNA)IBA 06/2010
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 06/2010
1	HKI 46F08IBA 10/2008
1	Histones (Histone)IBA 07/2008

Therapy/Procedure

15	Therapeutics 10/2023 - 07/2008
7	Drug Therapy (Chemotherapy) 01/2023 - 11/2011
2	Precision Medicine 01/2023 - 02/2022
2	Transplantation 12/2012 - 11/2011
1	Heterologous Transplantation (Xenotransplantation) 01/2023
1	Bioreactors (Bioreactor) 01/2017
1	Aftercare (After-Treatment) 01/2016
1	Immunotherapy 08/2013
1	Chemoradiotherapy 03/2009