John F O'Toole Selected Research

Kidney Diseases (Kidney Disease)

1/2021	Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation.
1/2021	Apolipoprotein L1 and mechanisms of kidney disease susceptibility.
11/2020	Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project.
1/2020	Association of preeclampsia with infant APOL1 genotype in African Americans.
11/2017	The Cell Biology of APOL1.
6/2014	Kidney disease: new technologies translate mechanisms to cure.
3/2014	Plasma apolipoprotein L1 levels do not correlate with CKD.
1/2013	Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.
11/2011	APOL1 localization in normal kidney and nondiabetic kidney disease.
2/2010	AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis.

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John F O'Toole Research Topics

Disease

10	Kidney Diseases (Kidney Disease) 01/2021 - 02/2010
4	Proteinuria 01/2023 - 03/2014
3	Fibrosis (Cirrhosis) 03/2016 - 08/2007
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2023 - 11/2011
2	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2023 - 06/2014
2	AIDS-Associated Nephropathy (HIV-Associated Nephropathy) 01/2019 - 11/2011
2	Chronic Renal Insufficiency 01/2019 - 06/2018
2	Retinal Degeneration 02/2010 - 06/2006
2	Agenesis of Cerebellar Vermis 02/2010 - 06/2006
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 06/2006 - 03/2005
1	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2023
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2023
1	Albuminuria 01/2022
1	Wilms Tumor (Wilm's Tumor) 01/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022
1	Trypanosomiasis 01/2019
1	Atrophy 03/2016
1	IGA Glomerulonephritis (IGA Nephropathy) 06/2014
1	Hypertension (High Blood Pressure) 06/2014
1	Acute Kidney Injury (Acute Renal Failure) 06/2014
1	Dyslipidemias (Dyslipidemia) 03/2014
1	Hypertensive Nephropathy 11/2011
1	Ciliopathies 05/2011
1	Blindness (Hysterical Blindness) 02/2010
1	Cysts 06/2006
1	Senior Loken Syndrome 03/2005

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2006
6	Apolipoprotein L1IBA 01/2021 - 11/2011
3	Retinaldehyde (Retinal)IBA 02/2010 - 03/2005
2	Messenger RNA (mRNA)IBA 01/2021 - 03/2016
2	Transcription Factors (Transcription Factor)IBA 08/2007 - 06/2006
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2023
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2023
1	Cathepsin DIBA 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	LipopolysaccharidesIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	ApolipoproteinsIBA 01/2020
1	CreatinineIBA 03/2014
1	CytokinesIBA 03/2014
1	X-Pro aminopeptidase (aminopeptidase P)IBA 01/2013
1	Carrier Proteins (Binding Protein)IBA 06/2006
1	Activating Transcription Factor 4IBA 06/2006
1	GTP Phosphohydrolases (GTPases)IBA 03/2005
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 03/2005

Therapy/Procedure

2	Therapeutics 01/2023 - 06/2014
2	Precision Medicine 11/2020 - 06/2018
1	Kidney Transplantation 06/2014