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Alice Nomura Selected Research

Neoplasms (Cancer)

1/2021Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology.
1/2018GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.
11/2017Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.
1/2017Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters.
12/2016Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer.
8/2016Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells.
1/2016A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies.
11/2015Minnelide effectively eliminates CD133(+) side population in pancreatic cancer.
4/2015Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas.
5/2014CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide.

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Alice Nomura Research Topics

Disease

10Neoplasms (Cancer)
01/2021 - 05/2014
10Pancreatic Neoplasms (Pancreatic Cancer)
12/2018 - 05/2014
3Tics (Tic)
12/2018 - 05/2014
2Hypoxia (Hypoxemia)
11/2017 - 01/2017
1Neoplasm Metastasis (Metastasis)
12/2018
1Retinoblastoma (Glioblastoma, Retinal)
04/2015
1Carcinoma (Carcinomatosis)
01/2014
1Carcinogenesis
01/2014
1Adenoma (Adenomas)
01/2014

Drug/Important Bio-Agent (IBA)

4Proteins (Proteins, Gene)FDA Link
01/2018 - 05/2014
414-O-phosphonooxymethyltriptolide disodium saltIBA
11/2017 - 05/2014
3triptolideIBA
11/2017 - 11/2015
2ATP-Binding Cassette Transporters (ABC Transporters)IBA
12/2018 - 01/2018
2Transcription Factors (Transcription Factor)IBA
01/2018 - 01/2017
2NF-kappa B (NF-kB)IBA
11/2017 - 12/2016
2ProdrugsIBA
11/2017 - 11/2015
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2021
1GemcitabineFDA Link
01/2021
1LipidsIBA
12/2018
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2018
1CaveolinsIBA
12/2018
1CholesterolIBA
12/2018
1EnzymesIBA
12/2018
1AntioxidantsIBA
01/2018
1Endoplasmic Reticulum Chaperone BiPIBA
01/2018
1CalciumIBA
01/2017
1CytokinesIBA
01/2017
1BAY 11-7085IBA
12/2016
1Nerve Growth Factor (NGF)IBA
12/2016
1Retinaldehyde (Retinal)IBA
04/2015
1E2F Transcription FactorsIBA
04/2015
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2014
1Dextrans (Dextran)FDA Link
01/2014
1CateninsIBA
01/2014

Therapy/Procedure

4Drug Therapy (Chemotherapy)
01/2021 - 08/2016
4Therapeutics
01/2018 - 05/2014