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Vincent C O Njar Selected Research

4- (+;- )- (1H- imidazole- 1- yl)- N- (4- fluorophenyl)- (E)- retinamide

1/2023VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
3/2019The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.

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Vincent C O Njar Research Topics

Disease

42Prostatic Neoplasms (Prostate Cancer)
10/2023 - 06/2003
29Neoplasms (Cancer)
10/2023 - 10/2004
10Breast Neoplasms (Breast Cancer)
01/2023 - 12/2004
4Neoplasm Metastasis (Metastasis)
03/2019 - 04/2010
2Triple Negative Breast Neoplasms
03/2019 - 01/2014
2Disease Progression
08/2017 - 01/2008
1Myeloproliferative Disorders (Myeloproliferative Disorder)
11/2020
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2017
1Carcinogenesis
05/2017
1Carcinoma (Carcinomatosis)
05/2012
1Acne Vulgaris
07/2006
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
07/2006
1Acute Promyelocytic Leukemia
07/2006
1Skin Neoplasms (Skin Cancer)
07/2006
1Kaposi Sarcoma (Kaposi's Sarcoma)
07/2006
1Psoriasis (Pustulosis Palmaris et Plantaris)
07/2006

Drug/Important Bio-Agent (IBA)

16Androgen Receptors (Androgen Receptor)IBA
02/2023 - 10/2006
15AndrogensIBA
10/2017 - 06/2003
103- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
10/2023 - 06/2013
9Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
05/2011 - 10/2004
8Tretinoin (Retinoic Acid)FDA LinkGeneric
08/2012 - 12/2004
7Eukaryotic Initiation Factor-4EIBA
01/2023 - 01/2014
64-(1H-imidazol-1-yl)retinoic acidIBA
07/2014 - 12/2004
6Hormones (Hormone)IBA
07/2008 - 10/2004
5Proteins (Proteins, Gene)FDA Link
01/2018 - 04/2008
4enzalutamideIBA
10/2023 - 10/2019
4Phosphotransferases (Kinase)IBA
03/2019 - 10/2006
3Mitogen-Activated Protein KinasesIBA
03/2019 - 12/2006
3Aromatase InhibitorsIBA
07/2014 - 12/2006
3Estrogens (Estrogen)FDA Link
05/2012 - 12/2006
3ProdrugsIBA
04/2010 - 08/2007
3EnzymesIBA
04/2010 - 08/2007
3Androgen Antagonists (Antiandrogens)IBA
08/2008 - 04/2005
3bicalutamide (Casodex)FDA LinkGeneric
08/2008 - 10/2004
2Docetaxel (Taxotere)FDA Link
10/2023 - 01/2023
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
02/2023 - 01/2023
2RNA (Ribonucleic Acid)IBA
02/2023 - 01/2022
24- (+;- )- (1H- imidazole- 1- yl)- N- (4- fluorophenyl)- (E)- retinamideIBA
01/2023 - 03/2019
2abirateroneIBA
01/2022 - 11/2011
2Messenger RNA (mRNA)IBA
01/2022 - 11/2016
2Therapeutic UsesIBA
10/2019 - 01/2018
2VimentinIBA
01/2018 - 11/2016
2Matrix Metalloproteinases (MMPs)IBA
01/2018 - 11/2016
2Cadherins (E-Cadherin)IBA
01/2018 - 11/2016
2Cyclin D1IBA
01/2018 - 12/2006
2Peptide Initiation Factors (Initiation Factor)IBA
05/2017 - 01/2014
2VNPT55IBA
11/2016 - 09/2015
2Aromatase (CYP19)IBA
07/2014 - 08/2007
2Letrozole (Femara)FDA LinkGeneric
07/2014 - 12/2006
2Chloroquine (Aralen)FDA LinkGeneric
08/2012 - 04/2012
2Estrogen ReceptorsIBA
05/2012 - 12/2006
2Abiraterone AcetateIBA
11/2011 - 05/2011
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2010 - 08/2007
2Mixed Function Oxygenases (Monooxygenases)IBA
09/2008 - 08/2008
2Histone Deacetylase InhibitorsIBA
07/2008 - 03/2008
2RetinoidsIBA
03/2008 - 07/2005
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2006 - 10/2006
1SaltsIBA
10/2023
1UbiquitinIBA
02/2023
1Eukaryotic Initiation Factor-4F (EIF4F)IBA
01/2023
1CytokinesIBA
03/2019
1Mechanistic Target of Rapamycin Complex 1IBA
03/2019
1ChemokinesIBA
03/2019
1CateninsIBA
01/2018
1ClaudinsIBA
01/2018
1Dihydrotachysterol (AT 10)IBA
01/2018
1retinamideIBA
01/2018
1Prostate-Specific Antigen (Semenogelase)IBA
01/2018
1LigandsIBA
10/2017
1GemcitabineFDA Link
08/2017
1Ether (Diethyl Ether)IBA
07/2016
1Cytochromes c (Cytochrome c)IBA
09/2015
1ThapsigarginIBA
07/2014
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
05/2012
1Estradiol (Delestrogen)FDA LinkGeneric
05/2012
1orteronelIBA
05/2011
1Ketoconazole (Nizoral)FDA LinkGeneric
05/2011
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
04/2010
1PhytochemicalsIBA
04/2010
1AntioxidantsIBA
04/2010
13beta- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
08/2008
1theasinensin AIBA
03/2008
1Isotretinoin (Accutane)FDA LinkGeneric
03/2008
1entinostat (MS 275)IBA
03/2008
1tacedinaline (CI 994)IBA
03/2008
1Androgen Receptor AntagonistsIBA
01/2008
1dehydroepiandrosterone acetateIBA
12/2007
1CytochromesIBA
12/2007
1Cholecalciferol (Vitamin D3)FDA Link
08/2007
1Vitamin A (Retinol)FDA LinkGeneric
08/2007
1Estrogen Receptor alphaIBA
12/2006
1TamoxifenFDA LinkGeneric
12/2006
1src-Family KinasesIBA
10/2006
1Tyrosine (L-Tyrosine)FDA Link
10/2006
1Histone Deacetylases (Histone Deacetylase)IBA
07/2005
1VorinostatFDA Link
07/2005

Therapy/Procedure

16Therapeutics
11/2020 - 06/2003
15Castration
02/2023 - 10/2004
2Chemoprevention
04/2010 - 08/2007
1Oral Administration
10/2023