Guiying Nie Selected Research

Neoplasms (Cancer)

1/2024	Podocalyxin promotes the formation of compact and chemoresistant cancer spheroids in high grade serous carcinoma.
10/2021	Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy Complications.
6/2021	Podocalyxin in Normal Tissue and Epithelial Cancer.
10/2017	The significance of post-translational removal of α-DG-N in early stage endometrial cancer development.
1/2014	Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.
1/2013	HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.
3/2012	Proprotein convertases in post-menopausal endometrial cancer: distinctive regulation and non-invasive diagnosis.
1/2012	HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.
10/2010	High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers.
10/2006	Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer.

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Guiying Nie Research Topics

Disease

11	Neoplasms (Cancer) 01/2024 - 03/2002
8	Pre-Eclampsia (Preeclampsia) 01/2021 - 02/2011
7	Endometrial Neoplasms (Endometrial Cancer) 06/2022 - 03/2002
2	Carcinoma (Carcinomatosis) 01/2024 - 03/2002
2	Neoplasm Metastasis (Metastasis) 06/2021 - 03/2002
2	Carcinogenesis 01/2018 - 03/2002
2	Infertility (Sterility) 03/2013 - 04/2011
2	HIV Infections (HIV Infection) 12/2012 - 04/2005
2	Ovarian Neoplasms (Ovarian Cancer) 10/2010 - 10/2006
1	Ascites 01/2024
1	Obesity 01/2023
1	Endometriosis 06/2022
1	Pregnancy Complications 10/2021
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/2019
1	Premature Birth (Birth, Premature) 01/2019
1	Uterine Diseases (Endometrial Disease) 11/2016
1	Arthritis (Polyarthritis) 01/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2014
1	Lymphatic Metastasis 12/2013
1	Breast Neoplasms (Breast Cancer) 12/2013
1	Serous Cystadenocarcinoma 01/2013
1	Cysts 01/2013
1	Granulosa Cell Tumor 10/2010
1	Female Infertility 08/2010
1	Melanoma (Melanoma, Malignant) 10/2006

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2024 - 03/2002
5	Peptide Hydrolases (Proteases)FDA Link 10/2021 - 01/2013
4	podocalyxinIBA 01/2024 - 11/2017
4	Serine Proteases (Serine Protease)IBA 01/2019 - 10/2006
4	Messenger RNA (mRNA)IBA 03/2013 - 03/2002
4	PC6 extract (PC6)IBA 12/2012 - 04/2005
3	Biomarkers (Surrogate Marker)IBA 06/2021 - 11/2016
3	Protein Isoforms (Isoforms)IBA 12/2018 - 01/2012
3	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 07/2016 - 03/2012
2	factor AIBA 01/2021 - 01/2014
2	FurinIBA 10/2017 - 03/2012
2	EnzymesIBA 10/2017 - 03/2002
1	Carboplatin (JM8)FDA LinkGeneric 01/2024
1	Advanced Glycation End ProductsIBA 01/2023
1	AntioxidantsIBA 01/2023
1	MicroRNAs (MicroRNA)IBA 06/2022
1	cadherin 5IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	Progesterone Receptors (Progesterone Receptor)IBA 12/2013
1	Estrogen ReceptorsIBA 12/2013
1	N 30IBA 03/2012
1	tetrapeptide carbamateIBA 03/2012
1	Monoclonal AntibodiesIBA 01/2012
1	Oxygen (Dioxygen)IBA 02/2011
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 03/2002
1	Tissue Inhibitor of Metalloproteinase-1IBA 03/2002
1	GelatinasesIBA 03/2002
1	Tissue Inhibitor of Metalloproteinase-2IBA 03/2002
1	Tissue Inhibitor of Metalloproteinase-3IBA 03/2002
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 03/2002
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2002
1	Matrix Metalloproteinases (MMPs)IBA 03/2002
1	Metalloproteases (Metalloproteinases)IBA 03/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2024
1	Hysterectomy 07/2016
1	Therapeutics 01/2014