Dorit Naot Selected Research

Uric Acid (Urate)

1/2022	Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout.
10/2018	Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state.
1/2018	Lack of Evidence that Soluble Urate Directly Influences Bone Remodelling: A Laboratory and Clinical Study.
4/2015	Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals.
9/2014	Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout.
12/2013	The effects of monosodium urate monohydrate crystals on chondrocyte viability and function: implications for development of cartilage damage in gout.
9/2011	Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout.
6/2008	Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells.

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Dorit Naot Research Topics

Disease

8	Gout 01/2022 - 06/2008
7	Bone Resorption 01/2019 - 09/2004
5	Osteoporosis 01/2019 - 05/2004
4	Hyperostosis corticalis deformans juvenilis 11/2014 - 09/2002
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2016 - 11/2007
2	Tendinopathy (Tendonitis) 04/2024 - 01/2023
2	Osteoarthritis 01/2021 - 11/2020
2	Secondary Hyperparathyroidism 08/2011 - 11/2007
1	Rotator Cuff Tear Arthropathy 01/2023
1	Hypophosphatemic Rickets 05/2020
1	Hypercalciuria 05/2020
1	Rickets (Rachitis) 05/2020
1	Breast Neoplasms (Breast Cancer) 11/2019
1	Weight Loss (Weight Reduction) 05/2017
1	Inflammation (Inflammations) 01/2017
1	Wounds and Injuries (Trauma) 01/2017
1	Foreign-Body Reaction 01/2017
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2016
1	Peritonitis 04/2015
1	Necrosis 04/2015
1	Pain (Aches) 11/2014
1	Cataract (Cataracts) 03/2014
1	Bone Diseases (Bone Disease) 03/2014
1	Hypocalcemia 03/2014
1	Obesity 01/2014
1	Insulin Resistance 08/2009
1	Measles 04/2008
1	Neoplasms (Cancer) 11/2007
1	Metabolic Bone Diseases (Osteopenia) 11/2007
1	Type 3 Maturity-Onset Diabetes of the Young 10/2003
1	Body Weight (Weight, Body) 06/2003

Drug/Important Bio-Agent (IBA)

8	Uric Acid (Urate)IBA 01/2022 - 06/2008
4	Imatinib Mesylate (Gleevec)FDA Link 01/2016 - 11/2007
4	OsteoprotegerinIBA 11/2014 - 09/2002
3	Proteins (Proteins, Gene)FDA Link 05/2020 - 03/2006
3	Peptides (Polypeptides)IBA 01/2019 - 06/2003
3	LactoferrinIBA 06/2010 - 09/2004
2	Phosphates (Orthophosphate)IBA 11/2020 - 05/2020
2	Zoledronic Acid (Zometa)FDA Link 11/2019 - 03/2014
2	AdiponectinIBA 05/2017 - 08/2009
2	Tyrosine Kinase InhibitorsIBA 01/2016 - 08/2011
2	nilotinib FDA Link 01/2016 - 08/2011
2	Insulin (Novolin)FDA Link 01/2014 - 10/2003
1	Chondroitinases and Chondroitin LyasesIBA 04/2024
1	Collagenases (Collagenase)FDA Link 04/2024
1	calcium phosphateIBA 01/2023
1	MineralsIBA 11/2020
1	CarbonatesIBA 11/2020
1	CollagenIBA 11/2020
1	LipidsIBA 11/2020
1	Phosphate Transport Proteins (Phosphate Transporter)IBA 05/2020
1	Diphosphonates (Bisphosphonates)IBA 11/2019
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2019
1	CalciumIBA 01/2019
1	Allopurinol (Remid)FDA LinkGeneric 01/2018
1	Interleukin-8 (Interleukin 8)IBA 04/2015
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 04/2015
1	Alkaline PhosphataseIBA 11/2014
1	Retinaldehyde (Retinal)IBA 03/2014
1	Risedronic Acid (Actonel)FDA LinkGeneric 03/2014
1	Denosumab FDA Link 03/2014
1	Islet Amyloid PolypeptideIBA 01/2014
1	Glucose (Dextrose)FDA LinkGeneric 01/2014
1	preptinIBA 01/2014
1	MitogensIBA 01/2011
1	bone resorption factorIBA 01/2011
1	GhrelinIBA 01/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2009
1	Macrophage Colony-Stimulating FactorIBA 06/2008
1	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 06/2008
1	RNA (Ribonucleic Acid)IBA 04/2008
1	Biomarkers (Surrogate Marker)IBA 11/2007
1	Phosphotransferases (Kinase)IBA 11/2007
1	Tyrosine (L-Tyrosine)FDA Link 11/2007
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 11/2007
1	Aspartic Acid (Aspartate)FDA Link 03/2006
1	Hepatocyte Nuclear Factor 1IBA 10/2003
1	A-factor (Streptomyces)IBA 06/2003
1	alpha-MSHIBA 06/2003
1	LeptinIBA 06/2003
1	AcidsIBA 06/2003

Therapy/Procedure

3	Therapeutics 06/2008 - 05/2004
1	Replacement Arthroplasty 01/2021
1	Sutures (Suture) 01/2017
1	Operative Surgical Procedures 01/2017