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James Murray Selected Research

VER-246608

12/2014VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.

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James Murray Research Topics

Disease

16Neoplasms (Cancer)
08/2023 - 12/2007
9Mitochondrial Diseases (Mitochondrial Disease)
05/2011 - 04/2003
7Breast Neoplasms (Breast Cancer)
12/2023 - 01/2005
6Wounds and Injuries (Trauma)
08/2023 - 05/2002
4Pain (Aches)
09/2022 - 01/2016
3Arthritis (Polyarthritis)
09/2023 - 01/2014
3Infections
08/2023 - 08/2020
3Leukemia
11/2020 - 10/2016
3Parkinson Disease (Parkinson's Disease)
12/2004 - 04/2003
2Snake Bites (Snake Bite)
11/2023 - 01/2022
2Residual Neoplasm
01/2023 - 01/2022
2Second Primary Neoplasms (Neoplasms, Second)
01/2023 - 01/2022
2Ovarian Neoplasms (Ovarian Cancer)
01/2017 - 03/2016
2Lymphoma (Lymphomas)
10/2016 - 08/2004
2Cytochrome-c Oxidase Deficiency
12/2007 - 11/2007
2Neurodegenerative Diseases (Neurodegenerative Disease)
02/2006 - 09/2003
1Hypertension (High Blood Pressure)
01/2023
1Cardiotoxicity
10/2022
1Cardiovascular Diseases (Cardiovascular Disease)
10/2022
1Myocarditis (Carditis)
10/2022
1Periodontitis
04/2022
1Gingivitis
04/2022
1Dental Caries (Decay, Dental)
04/2022
1Delirium
01/2022
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2022
1Postoperative Pain
01/2022
1Hemorrhage
01/2022
1Knee Injuries (Knee Injury)
08/2021
1Osteoarthritis
08/2021
1COVID-19
11/2020
1Mediastinal Emphysema (Pneumomediastinum)
11/2020
1Pneumothorax
11/2020
1B-Cell Lymphoma (Lymphoma, B Cell)
04/2018
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
04/2018
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
04/2018
1Multiple Myeloma
10/2016
1Type 2 Diabetes Mellitus (MODY)
06/2016
1Brain Diseases (Brain Disorder)
01/2016
1Sexually Transmitted Diseases (Sexually Transmitted Disease)
12/2015
1Glioblastoma (Glioblastoma Multiforme)
12/2015
1Brain Neoplasms (Brain Tumor)
12/2015
1Hypoxia (Hypoxemia)
12/2014
1Inflammation (Inflammations)
10/2014

Drug/Important Bio-Agent (IBA)

9Proteins (Proteins, Gene)FDA Link
11/2020 - 09/2003
4Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2017 - 12/2015
4rucaparibIBA
01/2017 - 12/2015
3Monoclonal AntibodiesIBA
01/2023 - 09/2004
3Biomarkers (Surrogate Marker)IBA
01/2022 - 09/2003
3EnzymesIBA
12/2014 - 02/2006
2Antivenins (Antivenoms)IBA
11/2023 - 01/2022
2Immune Checkpoint InhibitorsIBA
10/2022 - 01/2021
2AcidsIBA
02/2014 - 02/2005
2Anti-Bacterial Agents (Antibiotics)IBA
02/2014 - 12/2007
2Mitochondrial DNA (mtDNA)IBA
05/2011 - 10/2008
1PerforinIBA
01/2023
1Trastuzumab (Herceptin)FDA Link
01/2023
1AnthracyclinesIBA
01/2023
1Cytotoxins (Cytolysins)IBA
01/2023
1N,N- dimethyl- N- hexadecyl- 1- octadecylammonium (DDAC)IBA
01/2023
1omega-Chloroacetophenone (Mace)IBA
10/2022
1VenomsIBA
01/2022
1Tyrosine Kinase InhibitorsIBA
01/2022
1Adrenal Cortex Hormones (Corticosteroids)IBA
01/2021
1Polyethylene (Polythene)IBA
08/2020
1Apoptosis Regulatory ProteinsIBA
04/2018
1S55746IBA
04/2018
1venetoclaxIBA
04/2018
1Cell ExtractsIBA
01/2017
1S63845IBA
10/2016
1Insulin (Novolin)FDA Link
06/2016
1PlatinumIBA
03/2016
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
03/2016
1Imatinib Mesylate (Gleevec)FDA Link
01/2016
1Temozolomide (Temodar)FDA LinkGeneric
12/2015
1Adenosine Triphosphate (ATP)IBA
12/2014
1VER-246608IBA
12/2014
1Glutamine (L-Glutamine)FDA Link
12/2014
1Culture MediaIBA
12/2014
1Glucose (Dextrose)FDA LinkGeneric
12/2014
1Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA
12/2014
1Protein Isoforms (Isoforms)IBA
12/2014
1ArtesunateIBA
12/2014
1Oxygen (Dioxygen)IBA
12/2014

Therapy/Procedure

7Drug Therapy (Chemotherapy)
12/2023 - 10/2009
7Therapeutics
01/2023 - 08/2004
3Knee Replacement Arthroplasty (Total Knee Replacement)
08/2020 - 01/2016
3Length of Stay
03/2017 - 11/2005
2Prostheses and Implants (Prosthesis)
09/2022 - 08/2008
2Lasers (Laser)
12/2018 - 12/2015
2Condoms (Condom)
12/2015 - 08/2005
1Arthrodesis
09/2023
1Arthroplasty
08/2023
1Meniscectomy
09/2022
1Transplantation
09/2022
1Oral Hygiene (Dental Hygiene)
04/2022
1Tourniquets
01/2022
1Ligation
01/2022
1Osteotomy
08/2021
1Injections
01/2021
1Extracorporeal Membrane Oxygenation
11/2020