Michael Mullan Selected Research

Proteins (Proteins, Gene)

1/2024	Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain.
10/2013	Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo.
2/2013	Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier.
11/2011	Anatabine lowers Alzheimer's Aβ production in vitro and in vivo.
12/2009	Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta.
3/2007	CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway.
5/2005	Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors.
7/2004	Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice.
12/2003	Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice.
9/2003	Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation.

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Michael Mullan Research Topics

Disease

55	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2002
9	Cognitive Dysfunction 12/2023 - 01/2002
9	Brain Concussion (Cerebral Concussion) 01/2023 - 04/2014
7	Neuroinflammatory Diseases 06/2023 - 01/2013
7	Inflammation (Inflammations) 01/2022 - 04/2002
7	Amyloid Plaque 01/2010 - 09/2003
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 01/2018
5	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2024 - 01/2012
5	Wounds and Injuries (Trauma) 06/2023 - 01/2014
5	Gliosis 01/2023 - 02/2006
5	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2023 - 01/2014
4	Memory Disorders (Memory Loss) 01/2022 - 12/2004
4	Dementia (Dementias) 01/2018 - 11/2002
3	Craniocerebral Trauma (Head Injury) 01/2024 - 10/2021
3	Hypertension (High Blood Pressure) 01/2018 - 12/2004
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 01/2021
2	Tauopathies 01/2024 - 01/2015
2	Fatigue 01/2021 - 01/2020
2	Demyelinating Diseases (Demyelinating Disease) 01/2016 - 04/2014
2	Neuroblastoma 09/2008 - 04/2002
2	Neoplasms (Cancer) 05/2005 - 05/2004
1	Autoimmune Diseases (Autoimmune Disease) 01/2021
1	Chronic Pain 01/2021
1	Nervous System Diseases (Neurological Disorders) 01/2021
1	Neurobehavioral Manifestations 01/2021
1	Pain (Aches) 01/2021
1	Headache (Headaches) 01/2021
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Weight Loss (Weight Reduction) 01/2019
1	Frailty 01/2016
1	Amyloidosis 01/2015

Drug/Important Bio-Agent (IBA)

16	Apolipoproteins E (ApoE)IBA 01/2024 - 01/2002
16	Amyloid beta-PeptidesIBA 12/2019 - 09/2002
13	ApolipoproteinsIBA 01/2023 - 01/2002
12	Peptides (Polypeptides)IBA 06/2011 - 09/2002
11	Amyloid (Amyloid Fibrils)IBA 12/2018 - 07/2004
10	Proteins (Proteins, Gene)FDA Link 01/2024 - 09/2003
8	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2012
7	LipidsIBA 01/2023 - 01/2018
5	Protein Isoforms (Isoforms)IBA 01/2024 - 11/2002
5	Phospholipids (Phosphatides)FDA LinkGeneric 01/2023 - 12/2014
5	nilvadipine (Escor)IBA 01/2020 - 10/2014
5	anatabineIBA 01/2017 - 11/2011
4	Apolipoprotein E4IBA 01/2024 - 01/2013
4	CytokinesIBA 01/2023 - 01/2013
4	salicylhydroxamic acid (SHAM)IBA 10/2021 - 04/2014
4	1,4-dihydropyridine (dihydropyridine)IBA 01/2020 - 06/2011
4	CD40 Ligand (CD40L)IBA 09/2008 - 07/2004
3	Arachidonic Acid (Vitamin F)IBA 01/2023 - 01/2017
3	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2020 - 04/2012
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2011 - 05/2005
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2023 - 01/2019
2	OxylipinsIBA 01/2023 - 01/2021
2	Docosahexaenoic AcidsIBA 01/2022 - 01/2017
2	Metalloproteases (Metalloproteinases)IBA 01/2021 - 11/2020
2	Syk KinaseIBA 01/2019 - 01/2017
2	Ether (Diethyl Ether)IBA 01/2016 - 12/2014
2	Antihypertensive Agents (Antihypertensives)IBA 06/2011 - 11/2009
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2009 - 04/2002
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2024
1	Nerve Growth Factors (Neurotrophins)IBA 12/2023
1	InflammasomesIBA 06/2023
1	TensinsIBA 01/2023
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2023
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2023
1	anandamide (arachidonylethanolamide)IBA 01/2023
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2023
1	trimethyloxamine (trimethylamine N-oxide)IBA 01/2023
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2023
1	Permethrin (Ambush)FDA LinkGeneric 10/2022
1	Nerve AgentsIBA 10/2022
1	PesticidesIBA 10/2022
1	Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric 10/2022
1	Lipase (Acid Lipase)FDA Link 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022
1	Biotin (Vitamin H)FDA Link 10/2021
1	Angiopoietin-1IBA 10/2021
1	Caveolin 1IBA 10/2021
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2021
1	Hazardous Substances (Hazardous Materials)IBA 01/2021
1	nicotinamide-beta-ribosideIBA 01/2020
1	Sirtuin 1IBA 01/2020
1	SirtuinsIBA 01/2020
1	Lipoprotein Receptors (Lipoprotein Receptor)IBA 12/2019
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2019
1	Apolipoprotein E3IBA 01/2019
1	Insulin (Novolin)FDA Link 01/2019
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	oleoylethanolamideIBA 01/2018
1	erucylphosphocholineIBA 01/2016
1	EpitopesIBA 12/2014
1	Retinaldehyde (Retinal)IBA 04/2014

Therapy/Procedure

3	Therapeutics 01/2019 - 06/2011
1	Drug Therapy (Chemotherapy) 10/2021
1	Euthanasia (Mercy Killing) 01/2020
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2019
1	Treatment Delay 01/2017
1	Duration of Therapy 10/2014