Hiroyuki Mizuguchi Selected Research

Polyethylene Glycols (Polyethylene Glycol)

9/2011	Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy.
1/2010	Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.
12/2008	[Development of pegylated adenovirus vector for cancer gene therapy].
9/2007	Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.

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Hiroyuki Mizuguchi Research Topics

Disease

80	Neoplasms (Cancer) 03/2023 - 02/2002
23	Infections 02/2023 - 12/2002
15	Hypersensitivity (Allergy) 08/2022 - 04/2007
11	Seasonal Allergic Rhinitis (Hay Fever) 01/2022 - 12/2008
10	Allergic Rhinitis 02/2021 - 12/2008
9	Melanoma (Melanoma, Malignant) 01/2018 - 03/2002
8	Inflammation (Inflammations) 08/2022 - 05/2003
6	Circulating Neoplastic Cells 05/2018 - 10/2009
5	Insulin Resistance 04/2022 - 05/2003
4	Traumatic Brain Injuries (Traumatic Brain Injury) 11/2022 - 01/2020
4	Virus Diseases (Viral Diseases) 04/2022 - 12/2002
4	Communicable Diseases (Infectious Diseases) 02/2022 - 05/2003
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 05/2003
4	Carcinoma (Carcinomatosis) 01/2010 - 06/2005
3	Type 2 Diabetes Mellitus (MODY) 01/2024 - 07/2017
3	Hypoxia (Hypoxemia) 12/2023 - 05/2015
3	Pancreatic Neoplasms (Pancreatic Cancer) 02/2023 - 06/2009
3	Neoplasm Metastasis (Metastasis) 06/2022 - 07/2007
3	Drug-Related Side Effects and Adverse Reactions 09/2021 - 01/2012
3	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2006
3	Colitis 01/2020 - 05/2003
3	Sneezing 01/2018 - 12/2008
2	Hyperglycemia 01/2024 - 01/2005
2	Insulinoma 01/2024 - 02/2004
2	Non-alcoholic Fatty Liver Disease 01/2024 - 01/2023
2	Teratoma (Teratoid Tumor) 03/2021 - 12/2017
2	Atopic Dermatitis (Atopic Eczema) 02/2021 - 09/2018
2	Coinfection 01/2021 - 08/2004
2	Brain Edema (Cerebral Edema) 01/2021 - 01/2020
2	Lung Neoplasms (Lung Cancer) 05/2018 - 01/2010
2	Liver Diseases (Liver Disease) 01/2018 - 05/2016
2	Hemophilia B (Haemophilia B) 01/2018 - 09/2017
2	Liver Failure 01/2017 - 05/2016
2	Malignant Mesothelioma 01/2013 - 08/2011
2	type 2C Congenital disorder of glycosylation 01/2013 - 08/2008

Drug/Important Bio-Agent (IBA)

22	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2002
15	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2023 - 07/2005
13	Histamine (Histamine Dihydrochloride)FDA Link 01/2022 - 04/2007
13	Messenger RNA (mRNA)IBA 01/2022 - 06/2008
11	Histamine H1 Receptors (Histamine H1 Receptor)IBA 02/2021 - 04/2010
10	adenovirus receptorIBA 02/2023 - 03/2002
10	CytokinesIBA 01/2020 - 03/2002
9	Histamine Antagonists (Antihistamines)IBA 01/2022 - 09/2008
7	Thymidine KinaseIBA 09/2011 - 03/2002
6	Biomarkers (Surrogate Marker)IBA 01/2023 - 10/2009
6	Neutralizing AntibodiesIBA 12/2022 - 06/2004
6	VaccinesIBA 02/2022 - 01/2005
6	Peptides (Polypeptides)IBA 01/2017 - 04/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 02/2004
5	Antineoplastic Agents (Antineoplastics)IBA 02/2023 - 01/2006
5	LuciferasesIBA 12/2022 - 03/2002
5	MicroRNAs (MicroRNA)IBA 01/2019 - 11/2010
5	InterleukinsIBA 01/2018 - 03/2002
5	Interleukin-4 (Interleukin 4)IBA 01/2017 - 04/2003
5	AntigensIBA 05/2014 - 05/2003
5	Therapeutic UsesIBA 04/2012 - 03/2002
5	Interleukin-12 (IL 12)IBA 11/2008 - 12/2003
5	ChemokinesIBA 11/2008 - 08/2003
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2007 - 03/2002
5	arginyl-glycyl-aspartic acidIBA 06/2005 - 03/2002
4	Double-Stranded RNA (RNA, Double Stranded)IBA 12/2023 - 05/2015
4	LipidsIBA 01/2023 - 08/2008
4	Anti-Allergic Agents (Antiallergic Agents)IBA 08/2022 - 10/2015
4	CathepsinsIBA 05/2021 - 01/2015
4	AntibodiesIBA 01/2018 - 01/2010
4	IntegrinsIBA 08/2012 - 04/2002
4	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 09/2011 - 09/2007
4	Ganciclovir (Cytovene)FDA LinkGeneric 10/2008 - 03/2002
3	Indicators and Reagents (Reagents)IBA 01/2024 - 09/2012
3	Protein Kinases (Protein Kinase)IBA 12/2023 - 01/2018
3	Caspase 3 (Caspase-3)IBA 01/2023 - 12/2016
3	Interleukin-33IBA 08/2022 - 04/2012
3	Interleukin-9 (Interleukin 9)IBA 01/2020 - 01/2018
3	Capsid Proteins (Capsid Protein)IBA 03/2019 - 01/2015
3	Toluene 2,4-Diisocyanate (Toluene Diisocyanate)IBA 09/2018 - 06/2008
3	DNA (Deoxyribonucleic Acid)IBA 05/2018 - 11/2012
3	ErbB Receptors (EGF Receptor)IBA 12/2016 - 03/2004
3	LigandsIBA 06/2010 - 05/2003
2	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2021
2	Liposomes (Liposome)IBA 01/2023 - 05/2017
2	Propolis (Bee Bread)IBA 08/2022 - 01/2018
2	InterferonsIBA 01/2021 - 01/2015
2	Interleukin-10 (Interleukin 10)IBA 01/2020 - 05/2014
2	TolueneIBA 01/2018 - 03/2009
2	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2018 - 09/2017
2	Glutamine (L-Glutamine)FDA Link 01/2018 - 02/2004
2	Epithelial Cell Adhesion MoleculeIBA 05/2017 - 09/2011
2	adenovirus associated RNA (VA RNA)IBA 01/2017 - 01/2017
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 05/2016 - 05/2003
2	Histidine DecarboxylaseIBA 04/2016 - 06/2008
2	Dextrans (Dextran)FDA Link 01/2015 - 05/2003
2	Immunoglobulin E (IgE)IBA 01/2013 - 08/2008
2	EnzymesIBA 09/2011 - 07/2005

Therapy/Procedure

28	Therapeutics 08/2022 - 05/2003
8	Immunotherapy 03/2023 - 04/2004
4	Transplantation 03/2021 - 05/2016
3	Phototherapy (Light Therapy) 02/2021 - 01/2016
3	Liver Transplantation 01/2020 - 03/2010
2	Lasers (Laser) 08/2017 - 01/2016
2	Drug Therapy (Chemotherapy) 01/2013 - 09/2009