Koichi Miyake Selected Research

Dental Enamel Hypomineralization

1/2023	Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia.
1/2021	Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice.

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Koichi Miyake Research Topics

Disease

8	Neoplasms (Cancer) 01/2017 - 02/2003
7	Hypophosphatasia 01/2023 - 11/2011
4	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 10/2021 - 06/2006
3	Neuralgia (Stump Neuralgia) 01/2017 - 09/2013
3	Keloid 09/2015 - 12/2010
3	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 02/2007 - 04/2005
2	Osteomalacia 01/2023 - 11/2011
2	Dental Enamel Hypomineralization 01/2023 - 01/2021
2	Demyelinating Diseases (Demyelinating Disease) 10/2021 - 07/2010
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 10/2021 - 08/2015
2	Pain (Aches) 01/2017 - 09/2013
2	Burns 01/2014 - 05/2010
1	Scoliosis 01/2023
1	Chronic Renal Insufficiency 01/2023
1	Aortic Dissection 01/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2021
1	Injection Site Reaction 01/2021
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 06/2020
1	Foreign Bodies (Foreign Body) 02/2020
1	Aortic Aneurysm (Aneurysm, Aortic) 10/2018
1	Hyperalgesia 01/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2017
1	Leukemia 01/2017
1	Ischemia 01/2016
1	Stomatognathic Diseases (Dental Disease) 12/2015
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 02/2014
1	Choroidal Neovascularization 01/2014
1	Atrophy 01/2014
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2014
1	Acute Lung Injury 10/2013
1	Infarction (Infarctions) 10/2012
1	Seizures (Absence Seizure) 04/2012
1	Odontohypophosphatasia 04/2012
1	Infantile Hypophosphatasia 11/2011
1	Rickets (Rachitis) 11/2011
1	Parkinson Disease (Parkinson's Disease) 08/2011
1	Globoid Cell Leukodystrophy (Krabbe Disease) 07/2010
1	Nervous System Diseases (Neurological Disorders) 07/2010
1	Multiple Sclerosis 07/2010
1	Lung Neoplasms (Lung Cancer) 04/2010
1	Pathologic Processes 04/2010
1	Melanoma (Melanoma, Malignant) 10/2007

Drug/Important Bio-Agent (IBA)

7	Alkaline PhosphataseIBA 01/2023 - 11/2011
7	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2023 - 11/2011
4	MicroRNAs (MicroRNA)IBA 01/2017 - 04/2010
4	Small Interfering RNA (siRNA)IBA 03/2014 - 04/2005
3	Cerebroside-Sulfatase (Arylsulfatase A)IBA 10/2021 - 06/2006
3	EnzymesIBA 09/2015 - 06/2006
3	Proteins (Proteins, Gene)FDA Link 01/2014 - 09/2005
2	Green Fluorescent ProteinsIBA 01/2016 - 10/2012
2	CollagenIBA 09/2015 - 03/2014
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2014 - 12/2010
2	AngiostatinsIBA 09/2005 - 02/2003
2	ribosomal protein S19IBA 06/2005 - 04/2005
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2023
1	alizarinIBA 01/2023
1	Hematoxylin (Haematoxylon)IBA 01/2023
1	asfotase alfaIBA 01/2021
1	diphosphoric acid (pyrophosphoric acid)IBA 01/2021
1	MineralsIBA 01/2021
1	Telomerase (Telomerase Reverse Transcriptase)IBA 06/2020
1	telomerase RNA (bTR)IBA 06/2020
1	AlloysIBA 02/2020
1	Platinum Compounds (Compounds, Platinum)IBA 01/2017
1	Potassium Channels (Potassium Channel)IBA 01/2017
1	Core Binding Factors (Core-Binding Factor)IBA 01/2017
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 01/2017
1	amlexanox (Aphthasol)FDA Link 01/2017
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2017
1	Tissue Inhibitor of Metalloproteinase-2IBA 09/2015
1	ImmunosorbentsIBA 09/2015
1	Matrix Metalloproteinases (MMPs)IBA 09/2015
1	Tissue Inhibitor of Metalloproteinase-1IBA 03/2014
1	Collagen Type I (Type I Collagen)IBA 03/2014
1	Ataxin-3IBA 02/2014
1	SurvivinIBA 10/2013
1	RNA (Ribonucleic Acid)IBA 09/2013
1	PlasticsIBA 09/2013
1	Voltage-Gated Sodium ChannelsIBA 09/2013
1	Protein Subunits (Protein Subunit)IBA 09/2013
1	Messenger RNA (mRNA)IBA 09/2013
1	UbiquitinIBA 08/2011
1	Ligases (Synthetase)IBA 08/2011
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 08/2011
1	DNA (Deoxyribonucleic Acid)IBA 12/2010
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2010
1	InterleukinsIBA 10/2007
1	Conditioned Culture MediaIBA 10/2007

Therapy/Procedure

3	Therapeutics 10/2021 - 02/2006
2	Semiconductor Lasers 01/2014 - 05/2010
1	Stents 01/2022
1	Injections 01/2021
1	Enzyme Replacement Therapy 01/2021
1	Sutures (Suture) 02/2020
1	Endovascular Procedures 10/2018
1	Drug Therapy (Chemotherapy) 01/2017
1	Hematopoietic Stem Cell Transplantation 01/2017
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/2010
1	Transplantation 07/2010