Gilles Mithieux Selected Research

Lipids

1/2022	Portal Glucose Infusion, Afferent Nerve Fibers, and Glucose and Insulin Tolerance of Insulin-Resistant Rats.
1/2022	Cellular and metabolic effects of renin-angiotensin system blockade on glycogen storage disease type I nephropathy.
1/2021	The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice.
12/2020	Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease.
11/2020	Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a.
1/2020	Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.
11/2018	Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis.
11/2018	Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.
10/2018	Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context.
1/2018	Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases.

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Gilles Mithieux Research Topics

Disease

19	Insulin Resistance 10/2023 - 05/2006
14	Obesity 02/2024 - 08/2008
14	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2002
12	Body Weight (Weight, Body) 02/2024 - 11/2011
12	Glycogen Storage Disease (Glycogenosis) 04/2023 - 03/2011
11	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 04/2002
7	Hyperglycemia 01/2021 - 05/2006
6	Hepatomegaly 04/2023 - 03/2011
6	Non-alcoholic Fatty Liver Disease 01/2021 - 01/2016
5	Weight Loss (Weight Reduction) 02/2024 - 03/2014
5	Fibrosis (Cirrhosis) 01/2022 - 01/2018
5	Neoplasms (Cancer) 01/2021 - 10/2018
4	Glycogen Storage Disease Type I 01/2022 - 01/2016
4	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 04/2002
4	Metabolic Diseases (Metabolic Disease) 11/2019 - 01/2016
3	Chronic Renal Insufficiency 01/2022 - 10/2018
3	Inflammation (Inflammations) 01/2022 - 01/2020
3	Liver Cell Adenoma (Hepatocellular Adenoma) 11/2021 - 04/2015
3	AIDS-Related Complex (ARC) 01/2021 - 09/2014
3	Hepatorenal form of glycogen storage disease 12/2019 - 12/2017
2	Carcinoma (Carcinomatosis) 11/2021 - 05/2015
2	Hypertriglyceridemia 11/2021 - 01/2021
2	Carcinogenesis 01/2019 - 11/2018
2	Morbid Obesity 10/2018 - 09/2009
2	Rare Diseases (Rare Disease) 04/2015 - 03/2012
2	Acidosis 01/2014 - 12/2011
2	Hypoxia (Hypoxemia) 10/2013 - 10/2012
1	Weight Gain 10/2023
1	Liver Neoplasms (Liver Cancer) 04/2023
1	Chromosomal Instability (Chromosome Stability) 04/2023
1	Bites and Stings (Sting) 04/2023
1	Renal Insufficiency (Renal Failure) 01/2022
1	Anemia 01/2022
1	Anorexia 01/2022
1	Hemolysis 01/2022
1	Hemorrhage 11/2021
1	Fatty Liver 01/2021
1	Dyslipidemias (Dyslipidemia) 01/2021
1	Overweight 01/2021
1	Osteoporosis 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020

Drug/Important Bio-Agent (IBA)

40	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2002
14	LipidsIBA 01/2022 - 08/2009
13	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 10/2023 - 04/2002
11	Insulin (Novolin)FDA Link 10/2023 - 04/2002
9	GlycogenIBA 01/2022 - 03/2011
8	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2009
6	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022 - 03/2011
5	LeptinIBA 01/2021 - 08/2008
5	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 01/2002
4	Fatty Acids (Saturated Fatty Acids)IBA 12/2016 - 08/2009
3	GlucocorticoidsIBA 10/2023 - 12/2011
3	Dietary Fiber FDA Link 01/2023 - 01/2014
3	CarbohydratesIBA 01/2022 - 11/2020
3	Triglycerides (Triacylglycerol)IBA 01/2022 - 11/2020
3	Hypoglycemic Agents (Hypoglycemics)IBA 11/2021 - 04/2002
3	Sucrose (Saccharose)IBA 01/2020 - 07/2013
3	Hormones (Hormone)IBA 01/2020 - 04/2011
3	EnzymesIBA 01/2018 - 03/2011
3	Glucagon (Glukagon)FDA Link 04/2016 - 12/2011
2	Dietary ProteinsIBA 02/2024 - 01/2022
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2020
2	Carrier Proteins (Binding Protein)IBA 01/2021 - 11/2020
2	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 12/2019
2	Blood Glucose (Blood Sugar)IBA 06/2017 - 04/2015
2	AngiopoietinsIBA 12/2016 - 08/2014
2	fibroblast growth factor 21IBA 12/2016 - 08/2014
2	Leucine (L-Leucine)FDA Link 03/2014 - 01/2013
2	MelanocortinsIBA 04/2011 - 08/2008
2	Agouti-Related ProteinIBA 04/2011 - 08/2008
1	Deoxyglucose (2 Deoxy D glucose)IBA 10/2023
1	Fish OilsIBA 10/2023
1	FructoseIBA 10/2023
1	PhosphoenolpyruvateIBA 10/2023
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 10/2023
1	DNA (Deoxyribonucleic Acid)IBA 04/2023
1	SugarsIBA 01/2023
1	heme aIBA 01/2022
1	phospholipid emulsion soybean oil (Intralipid)IBA 01/2022
1	Capsaicin (Zostrix)FDA Link 01/2022
1	EmulsionsIBA 01/2022
1	Prothrombin (Factor II)IBA 11/2021
1	CorticosteroneIBA 11/2021
1	Adenosine Diphosphate (ADP)IBA 11/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	Lipid NanoparticlesIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	VLDL LipoproteinsIBA 01/2021
1	Nonesterified Fatty Acids (NEFA)IBA 01/2021
1	Starch (Cornstarch)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2020
1	KetonesIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Vitamin A (Retinol)FDA LinkGeneric 01/2020

Therapy/Procedure

10	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/2024 - 09/2008
3	Therapeutics 01/2021 - 03/2014
2	Glycemic Control 11/2021 - 01/2021
1	Catheters 01/2022
1	Kidney Transplantation 01/2022
1	Bariatric Surgery 01/2020