Paul S Meltzer Selected Research

Breast Neoplasms (Breast Cancer)

1/2014	MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
12/2013	Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.
12/2011	Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
7/2011	A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology.
1/2011	Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences.
10/2009	Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.
9/2009	Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
1/2009	TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.
8/2007	Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.
2/2004	Predicting continuous values of prognostic markers in breast cancer from microarray gene expression profiles.

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Paul S Meltzer Research Topics

Disease

82	Neoplasms (Cancer) 01/2023 - 01/2002
12	Breast Neoplasms (Breast Cancer) 01/2014 - 09/2003
9	Neoplasm Metastasis (Metastasis) 01/2020 - 02/2004
8	Melanoma (Melanoma, Malignant) 01/2020 - 05/2003
5	Carcinogenesis 01/2021 - 11/2003
5	Leukemia 01/2020 - 04/2006
5	Synovial Sarcoma (Synovioma) 12/2018 - 11/2002
5	Ewing Sarcoma (Sarcoma, Ewing) 09/2015 - 05/2006
4	Colorectal Neoplasms (Colorectal Cancer) 01/2023 - 01/2020
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 01/2013
4	Osteosarcoma (Osteogenic Sarcoma) 10/2019 - 01/2015
4	Brain Neoplasms (Brain Tumor) 03/2015 - 09/2009
3	Genomic Instability 01/2022 - 01/2014
3	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 05/2013
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2020 - 01/2019
3	Lung Neoplasms (Lung Cancer) 01/2018 - 08/2008
3	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/2013 - 09/2010
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023 - 11/2019
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 12/2019
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2021 - 01/2019
2	Rhabdomyosarcoma 01/2021 - 09/2015
2	Embryonal Rhabdomyosarcoma 01/2021 - 11/2013
2	Alveolar Rhabdomyosarcoma 01/2021 - 08/2010
2	Prostatic Neoplasms (Prostate Cancer) 12/2018 - 11/2013
2	Adenocarcinoma of Lung 11/2016 - 07/2015
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016 - 01/2012
2	Diffuse Intrinsic Pontine Glioma 06/2015 - 03/2012
2	Thymoma (Thymic Carcinoma) 12/2014 - 09/2010
2	Chordoma 01/2013 - 01/2010
2	Sarcoma (Soft Tissue Sarcoma) 03/2012 - 10/2005
2	Triple Negative Breast Neoplasms 10/2009 - 01/2009
2	Retinoblastoma (Glioblastoma, Retinal) 01/2005 - 01/2003
1	T-Cell Leukemia (Leukemia, T Cell) 10/2021
1	Hematologic Neoplasms (Hematological Malignancy) 10/2021
1	Microsatellite Instability 10/2020
1	Bites and Stings (Sting) 01/2020
1	Chromosomal Instability (Chromosome Stability) 01/2020
1	Hairy Cell Leukemia 01/2020

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
17	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2003
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2005
9	Transcription Factors (Transcription Factor)IBA 11/2021 - 11/2002
7	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2022 - 01/2013
7	MicroRNAs (MicroRNA)IBA 11/2017 - 10/2009
6	Messenger RNA (mRNA)IBA 01/2022 - 09/2009
6	Complementary DNA (cDNA)IBA 10/2013 - 01/2002
5	Oncogene Proteins (Oncogene Protein)IBA 01/2021 - 04/2006
5	ChromatinIBA 12/2018 - 04/2006
4	Estrogen ReceptorsIBA 07/2011 - 09/2003
3	nuclear pore complex protein 98IBA 01/2023 - 11/2019
3	EnzymesIBA 01/2022 - 12/2014
3	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 10/2021 - 06/2013
3	Succinic Acid (Succinate)IBA 01/2021 - 06/2013
3	PlatinumIBA 01/2021 - 05/2013
3	NucleotidesIBA 01/2018 - 09/2012
3	Histones (Histone)IBA 12/2014 - 10/2009
3	Hormones (Hormone)IBA 07/2011 - 11/2003
2	Calcibiotic Root Canal SealerIBA 01/2023 - 10/2018
2	Topoisomerase I InhibitorsIBA 01/2023 - 09/2015
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2023 - 01/2019
2	3' Untranslated Regions (3' UTR)IBA 01/2022 - 01/2019
2	Fumarate Hydratase (Fumarase)IBA 01/2022 - 01/2021
2	AntigensIBA 11/2021 - 02/2005
2	AntibodiesIBA 01/2021 - 01/2004
2	alpha-hydroxyglutarateIBA 01/2021 - 01/2014
2	Long Noncoding RNAIBA 10/2020 - 10/2020
2	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2018
2	Co-Repressor ProteinsIBA 01/2019 - 02/2014
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2018 - 09/2015
2	Coloring Agents (Dyes)IBA 09/2017 - 01/2004
2	Proto-Oncogene Proteins c-etsIBA 09/2015 - 11/2013
2	EWS-FLI fusion proteinIBA 09/2015 - 03/2015
2	dipinacoline glutamateIBA 06/2015 - 03/2012
2	Phosphotransferases (Kinase)IBA 06/2013 - 10/2005
2	Small Interfering RNA (siRNA)IBA 05/2013 - 08/2007
2	OligonucleotidesIBA 05/2013 - 01/2004
2	Glutamic Acid (Glutamate)FDA Link 01/2012 - 05/2003
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2010 - 01/2009
2	Estrogens (Estrogen)FDA Link 01/2009 - 09/2003
2	Cyclin D1IBA 08/2008 - 01/2005
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 09/2003 - 01/2003
1	UbiquitinIBA 01/2023
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2023
1	pevonedistatIBA 01/2023
1	Ligases (Synthetase)IBA 01/2023
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2023
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2021
1	Monoclonal AntibodiesIBA 01/2021
1	FumaratesIBA 01/2021
1	DNA HelicasesIBA 10/2020
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2020
1	purineIBA 01/2020
1	Circular RNAIBA 01/2020
1	exodeoxyribonuclease IIBA 01/2020
1	Cullin Proteins (Cullins)IBA 01/2020
1	A-Form DNA (A-DNA)IBA 01/2020
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2020
1	Tartrate-Resistant Acid PhosphataseIBA 01/2020

Therapy/Procedure

30	Therapeutics 01/2022 - 03/2004
6	Drug Therapy (Chemotherapy) 01/2020 - 10/2009