Luke McAlary Selected Research

Superoxide Dismutase-1

5/2024	Rapid classification of a novel ALS-causing I149S variant in superoxide dismutase-1.
1/2024	Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
1/2023	ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
1/2020	Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises.
1/2020	Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
1/2019	CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
1/2019	Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
10/2018	Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.
1/2018	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
11/2013	Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.

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Luke McAlary Research Topics

Disease

19	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2024 - 11/2013
6	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2024 - 01/2019
3	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 01/2019
1	Frontotemporal Dementia (Semantic Dementia) 01/2023
1	Disease Progression 01/2021
1	Brain Neoplasms (Brain Tumor) 11/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/2020
1	Amyloid angiopathy 01/2020
1	Neuroinflammatory Diseases 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Neuroblastoma 01/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020

Drug/Important Bio-Agent (IBA)

10	Superoxide Dismutase-1IBA 05/2024 - 11/2013
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2018
4	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2023 - 01/2017
4	PrionsIBA 01/2020 - 01/2019
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 02/2024 - 01/2019
2	UbiquitinIBA 01/2023 - 11/2020
2	CuATSMIBA 01/2022 - 01/2021
1	EnzymesIBA 05/2024
1	Oxygen (Dioxygen)IBA 05/2024
1	Free RadicalsIBA 05/2024
1	CopperIBA 01/2021
1	ThuliumIBA 11/2020
1	thulium oxideIBA 11/2020
1	OxidesIBA 11/2020
1	Protein AggregatesIBA 01/2020
1	Heat Shock Transcription FactorsIBA 01/2020
1	ApolipoproteinsIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	HDL LipoproteinsIBA 01/2020
1	Amyloid beta-PeptidesIBA 01/2020
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2020
1	InflammasomesIBA 01/2020
1	Prion ProteinsIBA 01/2019

Therapy/Procedure

1	Therapeutics 01/2019