Michael Manns Selected Research

Hepatitis B

10/2021	Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine: A Phase 3 Randomized Clinical Trial.
1/2020	RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection.
1/2010	Patient management and clinical decision making in HBV--aims of therapy and what we can achieve.
7/2002	Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene.

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Michael Manns Research Topics

Disease

24	Infections 12/2021 - 07/2002
19	Fibrosis (Cirrhosis) 01/2023 - 05/2002
13	Chronic Hepatitis C 09/2017 - 05/2002
11	Liver Diseases (Liver Disease) 12/2021 - 12/2005
10	Chronic Hepatitis B 01/2020 - 07/2002
7	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020 - 05/2002
6	Neoplasms (Cancer) 06/2014 - 06/2002
6	Hepatitis C 12/2013 - 05/2002
4	Hepatitis B 10/2021 - 07/2002
4	Hepatocellular Carcinoma (Hepatoma) 09/2017 - 06/2002
4	Hepatitis 06/2016 - 07/2002
3	Cholestasis 01/2023 - 06/2014
3	End Stage Liver Disease 01/2023 - 06/2014
3	Inflammation (Inflammations) 01/2023 - 05/2002
3	Chronic Hepatitis (Chronic Active Hepatitis) 10/2019 - 06/2013
2	Ulcerative Colitis 10/2019 - 07/2010
2	Sclerosing Cholangitis 01/2019 - 06/2014
2	Hereditary Hemorrhagic Telangiectasia 11/2017 - 11/2004
2	Fatty Liver 10/2017 - 12/2005
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2016 - 07/2006
2	Hepatitis D 12/2015 - 01/2012
2	Chronic Hepatitis D 12/2015 - 01/2012
1	Pruritus (Itching) 01/2023
1	Acute-On-Chronic Liver Failure 12/2021
1	Bacterial Infections (Bacterial Infection) 01/2021
1	Fever (Fevers) 01/2020
1	Disease Progression 12/2019
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/2019
1	Ascites 01/2018
1	Brain Diseases (Brain Disorder) 01/2018
1	Syncope (Fainting) 01/2017
1	Pulmonary Embolism 01/2017

Drug/Important Bio-Agent (IBA)

17	InterferonsIBA 01/2019 - 05/2002
15	Ribavirin (Virazole)FDA LinkGeneric 01/2017 - 05/2002
7	Antiviral Agents (Antivirals)IBA 01/2022 - 10/2002
6	Tenofovir (Viread)FDA Link 10/2019 - 12/2008
5	Biomarkers (Surrogate Marker)IBA 01/2023 - 08/2003
5	Proteins (Proteins, Gene)FDA Link 12/2004 - 01/2002
4	Hepatitis B e AntigensIBA 01/2020 - 12/2008
4	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2020 - 07/2002
4	RNA (Ribonucleic Acid)IBA 12/2015 - 08/2011
3	Alanine Transaminase (SGPT)IBA 01/2018 - 01/2010
3	SofosbuvirIBA 01/2018 - 06/2016
3	Telbivudine FDA Link 01/2016 - 02/2009
3	DNA (Deoxyribonucleic Acid)IBA 12/2015 - 12/2008
3	adefovirIBA 12/2015 - 01/2012
3	peginterferon alfa-2a (Pegasys)FDA Link 01/2015 - 01/2003
3	Interferon alpha-2 (Roferon-A)FDA Link 08/2014 - 01/2003
3	SimeprevirIBA 08/2014 - 01/2011
3	peginterferon alfa-2b (Pegintron)FDA Link 09/2011 - 05/2002
2	VaccinesIBA 10/2021 - 07/2002
2	AntigensIBA 01/2020 - 07/2002
2	NucleotidesIBA 01/2020 - 01/2011
2	ledipasvirIBA 01/2017 - 06/2016
2	sofosbuvir drug combination ledipasvirIBA 01/2017 - 06/2016
2	faldaprevirIBA 01/2016 - 02/2015
2	deleobuvirIBA 01/2016 - 02/2015
2	Protease Inhibitors (Protease Inhibitor)IBA 11/2014 - 08/2014
2	adefovir dipivoxil (Hepsera)FDA Link 01/2011 - 12/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2010 - 08/2005
2	Lamivudine (Epivir)FDA Link 02/2009 - 07/2002
2	Telomerase (Telomerase Reverse Transcriptase)IBA 08/2005 - 06/2003
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2023
1	Dihydrotachysterol (AT 10)IBA 01/2023
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2023
1	obeticholic acidIBA 01/2023
1	Bile Acids and Salts (Bile Acids)IBA 01/2023
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2021
1	Anti-Idiotypic AntibodiesIBA 10/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Reverse Transcriptase InhibitorsIBA 01/2020
1	NucleosidesIBA 01/2020
1	ARC-520IBA 01/2020
1	Factor XI (Plasma Thromboplastin Antecedent)IBA 01/2020
1	AutoantibodiesIBA 12/2019
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 12/2019
1	SteroidsIBA 10/2019
1	simtuzumabIBA 01/2019
1	Alkaline PhosphataseIBA 01/2019
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2019
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2018
1	AlbuminsIBA 01/2018
1	Bevacizumab (Avastin)FDA Link 11/2017
1	Amiodarone (Amiodarona)FDA LinkGeneric 10/2017
1	Anti-Arrhythmia AgentsIBA 10/2017
1	CreatinineIBA 01/2017
1	Cytidine Triphosphate (CTP)IBA 06/2016
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2016
1	ALF-5755IBA 01/2016
1	C-Type Lectins (C-Type Lectin)IBA 01/2016
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2016
1	AntioxidantsIBA 01/2016
1	EnzymesIBA 12/2015

Therapy/Procedure

21	Therapeutics 01/2023 - 01/2002
5	Liver Transplantation 06/2016 - 07/2006
4	Aftercare (After-Treatment) 12/2015 - 05/2002
2	Subcutaneous Injections 01/2019 - 08/2014
2	Transplantation 06/2016 - 07/2006
2	Drug Therapy (Chemotherapy) 08/2005 - 01/2004
1	Rejuvenation 01/2020