Andrew Madin Selected Research

Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)

10/2021

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

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Andrew Madin Research Topics

Disease

6	Neoplasms (Cancer) 11/2022 - 02/2007
1	Reperfusion Injury 06/2023
1	Glioma (Gliomas) 01/2022
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2007
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 02/2007

Drug/Important Bio-Agent (IBA)

1	Proto-Oncogene Proteins c-metIBA 11/2022
1	hematopoietic progenitor kinase 1IBA 01/2022
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 10/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2019
1	TNF Receptor-Associated Factor 2 (TRAF2)IBA 01/2019
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 09/2011
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 09/2011
1	Gamma Secretase Inhibitors and ModulatorsIBA 02/2007
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2007
1	EnzymesIBA 02/2007

Therapy/Procedure

1	Nerve Crush 06/2023