Jennifer A Ligibel Selected Research

Metformin (Glucophage)

12/2023	Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer.
7/2023	Metformin, placebo, and endocrine therapy discontinuation among participants in a randomized double-blind trial of metformin vs placebo in hormone receptor-positive early-stage breast cancer (CCTG MA32).
1/2022	Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial.
10/2021	Cancer Antigen 15-3/Mucin 1 Levels in CCTG MA.32: A Breast Cancer Randomized Trial of Metformin vs Placebo.
6/2021	Effect of metformin versus placebo on metabolic factors in the MA.32 randomized breast cancer trial.
12/2020	Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial.
2/2020	Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors.
1/2018	Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
7/2017	Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32.
3/2015	Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32.

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Jennifer A Ligibel Research Topics

Disease

54	Breast Neoplasms (Breast Cancer) 03/2024 - 06/2002
37	Neoplasms (Cancer) 05/2024 - 08/2010
10	Fatigue 05/2024 - 06/2014
8	Weight Loss (Weight Reduction) 01/2024 - 07/2014
8	Obesity 11/2023 - 12/2012
7	Peripheral Nervous System Diseases (PNS Diseases) 03/2023 - 09/2014
6	Body Weight (Weight, Body) 12/2022 - 02/2008
5	Pain (Aches) 01/2022 - 07/2014
4	Ovarian Neoplasms (Ovarian Cancer) 01/2023 - 12/2017
3	Colorectal Neoplasms (Colorectal Cancer) 02/2024 - 05/2013
3	Insulin Resistance 01/2023 - 02/2008
3	Inflammation (Inflammations) 01/2023 - 12/2020
3	Type 2 Diabetes Mellitus (MODY) 01/2022 - 02/2011
3	Overweight 01/2021 - 02/2008
2	Triple Negative Breast Neoplasms 12/2023 - 07/2015
2	Pathologic Complete Response 12/2023 - 01/2013
2	Hematologic Neoplasms (Hematological Malignancy) 01/2023 - 01/2018
2	Second Primary Neoplasms (Neoplasms, Second) 03/2022 - 11/2014
2	Hypertension (High Blood Pressure) 01/2022 - 01/2019
2	Leukemia 01/2021 - 01/2018
2	Weight Gain 01/2019 - 08/2010
2	Lymphedema (Milroy Disease) 09/2014 - 04/2013
2	Brain Neoplasms (Brain Tumor) 11/2013 - 12/2011
1	Death (Near-Death Experience) 05/2024
1	Heart Failure 02/2024
1	Chronic Disease (Chronic Diseases) 07/2023
1	Drug-Related Side Effects and Adverse Reactions 07/2023
1	COVID-19 04/2023
1	Hot Flashes 10/2022
1	Nausea 05/2022
1	Menstruation Disturbances 01/2022
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022
1	Postoperative Pain 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Diarrhea 01/2022
1	Hypesthesia (Numbness) 09/2021

Drug/Important Bio-Agent (IBA)

13	Biomarkers (Surrogate Marker)IBA 02/2024 - 04/2013
13	Metformin (Glucophage)FDA LinkGeneric 12/2023 - 07/2009
11	Hormones (Hormone)IBA 12/2023 - 04/2003
6	Insulin (Novolin)FDA Link 01/2023 - 02/2008
5	Aromatase InhibitorsIBA 09/2018 - 04/2003
4	LeptinIBA 01/2023 - 10/2009
3	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 02/2008
3	taxaneIBA 01/2021 - 07/2015
3	Paclitaxel (Taxol)FDA LinkGeneric 09/2015 - 06/2002
2	Estrogen ReceptorsIBA 12/2023 - 09/2015
2	human ERBB2 proteinIBA 12/2023 - 11/2013
2	ErbB Receptors (EGF Receptor)IBA 12/2023 - 07/2015
2	AdiponectinIBA 01/2023 - 10/2009
2	AdipokinesIBA 01/2023 - 10/2009
2	Tumor Biomarkers (Tumor Markers)IBA 12/2022 - 10/2021
2	Lapatinib (GW572016)FDA Link 01/2022 - 11/2013
2	Interleukin-6 (Interleukin 6)IBA 12/2020 - 01/2018
2	C-Reactive ProteinIBA 12/2020 - 03/2015
2	Proteins (Proteins, Gene)FDA Link 09/2020 - 06/2002
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 01/2016
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/2015 - 07/2015
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2015 - 07/2015
2	Tamoxifen FDA LinkGeneric 01/2012 - 04/2003
1	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2024
1	pro-brain natriuretic peptide (1-76)IBA 02/2024
1	Brain Natriuretic Peptide (Natrecor)FDA Link 02/2024
1	Advanced Glycation End ProductsIBA 01/2024
1	Progesterone Receptors (Progesterone Receptor)IBA 12/2023
1	Clostridium perfringens epsilon-toxinIBA 01/2023
1	VS 261IBA 01/2023
1	LipidsIBA 01/2023
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2023
1	BiguanidesIBA 01/2022
1	MucinsIBA 10/2021
1	AntigensIBA 10/2021
1	DNA (Deoxyribonucleic Acid)IBA 10/2021
1	Mucin-1 (CA 15-3 Antigen)IBA 10/2021
1	Proteasome InhibitorsIBA 09/2021
1	Taxoids (Taxanes)IBA 09/2021
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2021
1	Nerve Growth Factors (Neurotrophins)IBA 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2020
1	Amino Acids FDA Link 09/2020

Therapy/Procedure

28	Therapeutics 11/2023 - 01/2003
22	Drug Therapy (Chemotherapy) 03/2024 - 06/2002
6	Adjuvant Chemotherapy 10/2021 - 08/2010
4	Aftercare (After-Treatment) 05/2024 - 06/2014
4	Preoperative Exercise 12/2023 - 09/2019
4	Caloric Restriction 03/2022 - 01/2017
3	Length of Stay 01/2022 - 05/2013
3	Resistance Training 11/2019 - 02/2008
3	Radiotherapy 07/2014 - 12/2011
2	Integrative Oncology 05/2024 - 01/2022
2	Qigong (Qi Gong) 05/2024 - 01/2022
1	Tai Ji (Tai Chi Chuan) 05/2024
1	Diet Therapy (Therapy, Diet) 01/2024
1	Neoadjuvant Therapy 12/2023
1	Polypharmacy 07/2023
1	Acupressure (Shiatsu) 04/2023
1	Ear Acupuncture 05/2022
1	Music Therapy 04/2022
1	Massage (Zone Therapy) 01/2022
1	Meditation 01/2022