Hong-Yu Li Selected Research

Proteolysis Targeting Chimera

8/2022	Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction.
10/2021	Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG.

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Hong-Yu Li Research Topics

Disease

50	Neoplasms (Cancer) 03/2024 - 12/2002
13	Pancreatic Neoplasms (Pancreatic Cancer) 02/2017 - 07/2005
6	Hepatocellular Carcinoma (Hepatoma) 06/2018 - 12/2002
4	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020 - 03/2006
4	Infections 09/2017 - 01/2014
3	Melanoma (Melanoma, Malignant) 03/2024 - 04/2015
3	Carcinogenesis 10/2023 - 03/2006
3	Liver Neoplasms (Liver Cancer) 01/2023 - 02/2020
3	Colorectal Neoplasms (Colorectal Cancer) 04/2021 - 01/2018
3	Liver Cirrhosis (Hepatic Cirrhosis) 12/2020 - 06/2018
2	End Stage Liver Disease 01/2023 - 06/2018
2	Breast Neoplasms (Breast Cancer) 10/2022 - 10/2014
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021 - 01/2018
2	Thyroid Neoplasms (Thyroid Cancer) 11/2020 - 01/2017
2	Neoplasm Metastasis (Metastasis) 07/2020 - 03/2017
2	Leukemia 08/2019 - 12/2017
2	Body Weight (Weight, Body) 01/2017 - 01/2011
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2016 - 01/2016
2	Classical Swine Fever (Swine Fever) 10/2011 - 09/2010
1	Squamous Cell Carcinoma of Head and Neck 12/2023
1	Cerebral Infarction 11/2023
1	Bites and Stings (Sting) 10/2023
1	Hyperbilirubinemia 10/2023
1	Methylenetetrahydrofolate reductase deficiency 10/2023
1	Primary Effusion Lymphoma 01/2023
1	Ganglion Cysts (Ganglion) 01/2023
1	Hypoxia (Hypoxemia) 01/2023
1	Stomach Neoplasms (Stomach Cancer) 01/2023
1	Coma (Comas) 01/2023
1	Medium chain acyl CoA dehydrogenase deficiency 10/2022
1	Triple Negative Breast Neoplasms 10/2022
1	Alzheimer Disease (Alzheimer's Disease) 08/2022
1	Sepsis (Septicemia) 12/2021
1	Second Primary Neoplasms (Neoplasms, Second) 04/2021

Drug/Important Bio-Agent (IBA)

11	Phosphotransferases (Kinase)IBA 01/2022 - 11/2011
10	Proteins (Proteins, Gene)FDA Link 10/2021 - 07/2013
6	RNA (Ribonucleic Acid)IBA 12/2023 - 09/2013
4	Messenger RNA (mRNA)IBA 02/2017 - 12/2002
4	AntigensIBA 01/2016 - 12/2005
3	Aurora Kinase BIBA 11/2023 - 12/2019
3	Oncogene Proteins (Oncogene Protein)IBA 10/2023 - 08/2019
3	MethyltransferasesIBA 03/2021 - 10/2014
3	SolutionsIBA 01/2014 - 06/2009
2	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 05/2021
2	Retinaldehyde (Retinal)IBA 01/2023 - 01/2018
2	benzimidazoleIBA 10/2022 - 01/2018
2	Proteolysis Targeting ChimeraIBA 08/2022 - 10/2021
2	fms-Like Tyrosine Kinase 3IBA 12/2021 - 01/2018
2	Carbapenems (Carbapenem Antibiotics)IBA 12/2021 - 01/2017
2	Lactic Acid (Lactate)FDA LinkGeneric 05/2021 - 01/2019
2	Adenosine Triphosphate (ATP)IBA 05/2021 - 04/2002
2	TropomyosinIBA 04/2021 - 01/2019
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2020 - 12/2013
2	Sorafenib (BAY 43-9006)FDA Link 02/2020 - 05/2015
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020 - 01/2017
2	Monoclonal AntibodiesIBA 02/2017 - 12/2005
2	Caspase 3 (Caspase-3)IBA 02/2016 - 08/2013
2	Irbesartan FDA LinkGeneric 01/2016 - 01/2016
2	CateninsIBA 12/2015 - 06/2015
2	Gemcitabine FDA Link 12/2015 - 06/2015
2	Cancer VaccinesIBA 10/2015 - 09/2013
2	ArsenicIBA 01/2014 - 01/2010
2	arsenic disulfide (realgar)IBA 01/2014 - 06/2009
2	Glycoproteins (Glycoprotein)IBA 10/2011 - 03/2011
1	Immune Checkpoint InhibitorsIBA 03/2024
1	Long Noncoding RNAIBA 12/2023
1	Glial Fibrillary Acidic ProteinIBA 11/2023
1	Thrombospondin 1IBA 11/2023
1	Betaine (C.B.B.)FDA Link 10/2023
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 10/2023
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 10/2023
1	4-hexyloxyaniline (HOA)IBA 01/2023
1	Trastuzumab (Herceptin)FDA Link 01/2023
1	Metformin (Glucophage)FDA LinkGeneric 01/2023
1	human ERBB2 proteinIBA 01/2023
1	AcidsIBA 10/2022
1	Progesterone Receptors (Progesterone Receptor)IBA 10/2022
1	Estrogen ReceptorsIBA 10/2022
1	imidazoleIBA 10/2022
1	pyrimidineIBA 01/2022
1	pyridineIBA 12/2021
1	ThiophenesIBA 12/2021
1	Transcription Factors (Transcription Factor)IBA 10/2021
1	DNA-Binding Proteins (DNA Binding Protein)IBA 10/2021
1	Lymphoid Enhancer-Binding Factor 1IBA 10/2021
1	Peptides (Polypeptides)IBA 08/2021
1	IntegrinsIBA 08/2021
1	NAD (NADH)IBA 05/2021
1	Nicotinamide MononucleotideIBA 05/2021
1	EnzymesIBA 05/2021
1	hepatitis B virus X proteinIBA 05/2021
1	Nicotinamide PhosphoribosyltransferaseIBA 05/2021
1	AcetamidesIBA 04/2021

Therapy/Procedure

12	Therapeutics 11/2023 - 09/2013
4	Immunotherapy 03/2024 - 10/2011
4	Liver Transplantation 01/2023 - 01/2012
2	Drug Therapy (Chemotherapy) 01/2023 - 06/2018
2	Transplantation 01/2023 - 01/2012
2	Hepatectomy 02/2018 - 03/2017
1	Chronotherapy 01/2023