Virginia M-Y Lee Selected Research

Proteins (Proteins, Gene)

4/2024	Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye.
2/2024	O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology.
3/2023	O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.
1/2023	Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model.
1/2023	A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
1/2023	Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein.
1/2022	Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology.
1/2022	Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology.
12/2021	Distinct brain-derived TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo.
1/2021	Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.

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Virginia M-Y Lee Research Topics

Disease

125	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 05/2002
89	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 05/2002
66	Parkinson Disease (Parkinson's Disease) 05/2024 - 07/2002
59	Tauopathies 03/2024 - 06/2002
58	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 02/2023 - 06/2006
48	Frontotemporal Dementia (Semantic Dementia) 02/2023 - 05/2003
44	Synucleinopathies 01/2023 - 05/2002
43	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2023 - 11/2004
39	Dementia (Dementias) 05/2024 - 06/2002
24	Amyloid Plaque 10/2020 - 03/2002
18	Cognitive Dysfunction 03/2023 - 01/2002
13	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019 - 09/2004
11	TDP-43 Proteinopathies 01/2023 - 07/2007
10	Multiple System Atrophy 01/2023 - 12/2002
9	Corticobasal Degeneration 11/2019 - 06/2002
9	Parkinsonian Disorders (Parkinsonism) 01/2019 - 12/2002
8	Amyloidosis 03/2011 - 07/2002
6	Neoplasms (Cancer) 01/2020 - 09/2002
6	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2018 - 02/2012
5	Movement Disorders (Movement Disorder) 01/2019 - 05/2002
5	Pick Disease of the Brain (Pick's Disease) 01/2017 - 06/2002
4	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2023 - 12/2004
4	Neuroinflammatory Diseases 01/2022 - 02/2007
4	Inflammation (Inflammations) 01/2022 - 07/2008
4	Atrophy 01/2021 - 11/2003
4	Disease Progression 01/2021 - 02/2004
4	Proteostasis Deficiencies 01/2020 - 02/2013
4	Gliosis 01/2020 - 12/2002
3	Lewy Body Disease (Lewy Body Dementia) 10/2023 - 07/2011
3	limbic-predominant age-related TDP-43 encephalopathy 01/2022 - 12/2021
3	Central Nervous System Diseases (CNS Diseases) 09/2014 - 01/2006
3	Brain Injuries (Brain Injury) 12/2005 - 08/2004
3	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2005 - 12/2002
2	Brain Diseases (Brain Disorder) 01/2020 - 04/2013
2	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 05/2019 - 01/2006
2	Brain Neoplasms (Brain Tumor) 01/2017 - 08/2003
2	Hippocampal Sclerosis 09/2014 - 12/2011
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 03/2011 - 08/2010
2	Down Syndrome (Down's Syndrome) 12/2009 - 08/2006

Drug/Important Bio-Agent (IBA)

91	Proteins (Proteins, Gene)FDA Link 04/2024 - 05/2002
44	SynucleinsIBA 05/2024 - 05/2002
44	alpha-SynucleinIBA 01/2023 - 05/2002
43	Amyloid (Amyloid Fibrils)IBA 02/2024 - 05/2002
38	tau Proteins (tau Protein)IBA 01/2023 - 06/2002
33	DNA-Binding Proteins (DNA Binding Protein)IBA 02/2023 - 07/2007
31	Biomarkers (Surrogate Marker)IBA 05/2024 - 12/2003
30	Amyloid beta-PeptidesIBA 01/2023 - 05/2002
25	Peptides (Polypeptides)IBA 01/2023 - 03/2002
23	UbiquitinIBA 02/2023 - 12/2002
14	AntibodiesIBA 05/2024 - 06/2002
12	ProgranulinsIBA 08/2012 - 03/2007
11	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 03/2024 - 11/2004
11	Protein Isoforms (Isoforms)IBA 01/2022 - 06/2002
10	DNA (Deoxyribonucleic Acid)IBA 02/2023 - 10/2003
9	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2023 - 05/2002
7	Excipients (Suspending Agents)IBA 09/2017 - 08/2012
7	Carrier Proteins (Binding Protein)IBA 09/2014 - 01/2005
6	EnzymesIBA 01/2023 - 12/2002
6	Protein AggregatesIBA 04/2015 - 01/2004
5	Apolipoproteins E (ApoE)IBA 12/2021 - 07/2006
4	RNA-Binding Proteins (RNA-Binding Protein)IBA 03/2024 - 05/2008
4	Monoclonal AntibodiesIBA 01/2019 - 11/2003
4	Amyloidogenic ProteinsIBA 01/2018 - 06/2004
4	LigandsIBA 01/2017 - 11/2002
4	thioflavin TIBA 08/2013 - 04/2005
4	Paclitaxel (Taxol)FDA LinkGeneric 04/2011 - 07/2007
4	IsoprostanesIBA 08/2010 - 01/2002
4	Valosin Containing ProteinIBA 06/2010 - 07/2007
3	Complement System Proteins (Complement)IBA 02/2023 - 05/2003
3	ApolipoproteinsIBA 12/2021 - 07/2006
3	Phosphotransferases (Kinase)IBA 01/2016 - 12/2005
3	desoxyepothilone B (epothilone D)IBA 09/2013 - 10/2010
3	Flavin-Adenine Dinucleotide (FAD)IBA 08/2013 - 06/2008
3	polyglutamineIBA 03/2011 - 01/2004
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2006 - 01/2004
3	Vitamin E FDA LinkGeneric 08/2004 - 02/2004
2	Fluorescent Dyes (Fluorescent Probes)IBA 04/2024 - 03/2020
2	PyrimidinesIBA 12/2023 - 01/2021
2	CytokinesIBA 01/2020 - 11/2008
2	VaccinesIBA 01/2020 - 11/2002
2	Staphylococcal Protein A (Protein A)IBA 01/2019 - 09/2004
2	Doxycycline (Periostat)FDA LinkGeneric 10/2018 - 12/2015
2	aspartyl- arginyl- valyl- tyrosyl- isoleucyl- histidyl- prolyl- phenylalanyl- histidyl- leucyl- valyl- isoleucyl- histidine (hTDP)IBA 10/2018 - 01/2016
2	CalciumIBA 10/2016 - 06/2008
2	Amino Acids FDA Link 12/2015 - 01/2012
2	Glial Fibrillary Acidic ProteinIBA 05/2014 - 04/2005
2	Lysine (L-Lysine)FDA Link 08/2013 - 03/2012
2	Threonine (L-Threonine)FDA Link 04/2013 - 04/2009
2	Thromboxane Receptors (Thromboxane Receptor)IBA 11/2012 - 04/2008
2	Glycogen Synthase Kinase 3IBA 05/2012 - 05/2003
2	Glycogen Synthase (Synthase I)IBA 05/2012 - 12/2005
2	EpitopesIBA 03/2012 - 09/2004
2	SodiumIBA 05/2010 - 07/2007
2	Nuclear Proteins (Protein, Nuclear)IBA 04/2010 - 06/2008
2	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)IBA 04/2010 - 06/2004
2	Coloring Agents (Dyes)IBA 04/2010 - 10/2006
2	Messenger RNA (mRNA)IBA 01/2010 - 07/2007

Therapy/Procedure

26	Therapeutics 12/2023 - 04/2002
4	Injections 01/2020 - 02/2015
2	Immunotherapy 01/2020 - 01/2015