Kyung Lee Selected Research

Fibrosis (Cirrhosis)

3/2024	HIPK2 C-terminal domain inhibits NF-κB signaling and renal inflammation in kidney injury.
2/2024	Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy against Kidney Fibrosis.
12/2023	Chronic kidney disease in a murine model of non-alcoholic steatohepatitis (NASH).
1/2023	Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development.
1/2023	HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy.
10/2022	Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression.
1/2022	Modulation of transforming growth factor-β-induced kidney fibrosis by leucine-rich ⍺-2 glycoprotein-1.
1/2022	Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit.
1/2021	Inhibition of apoptosis signal-regulating kinase 1 mitigates the pathogenesis of human immunodeficiency virus-associated nephropathy.
1/2020	Tubular HIPK2 is a key contributor to renal fibrosis.

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Kyung Lee Research Topics

Disease

17	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 01/2014
15	Fibrosis (Cirrhosis) 03/2024 - 01/2015
13	Kidney Diseases (Kidney Disease) 03/2024 - 01/2015
9	Proteinuria 12/2023 - 01/2016
9	Albuminuria 01/2021 - 06/2015
6	Disease Progression 04/2024 - 04/2015
6	Chronic Renal Insufficiency 03/2024 - 07/2015
6	AIDS-Associated Nephropathy (HIV-Associated Nephropathy) 11/2023 - 12/2017
3	Acute Kidney Injury (Acute Renal Failure) 03/2024 - 01/2016
3	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2020
3	COVID-19 01/2023 - 07/2021
3	Glomerulonephritis 01/2022 - 12/2017
3	Inflammation (Inflammations) 01/2021 - 10/2019
2	Ureteral Obstruction 03/2024 - 01/2022
2	Lupus Nephritis 12/2018 - 01/2018
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 11/2018 - 01/2016
1	Wounds and Injuries (Trauma) 04/2024
1	Bites and Stings (Sting) 01/2024
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2023
1	Acquired Immunodeficiency Syndrome (AIDS) 11/2023
1	Hyponatremia 11/2023
1	Colitis 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Cytokine Release Syndrome 01/2022
1	Rupture 01/2022
1	Hypertrophy 09/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	Nephrotic Syndrome (Syndrome, Nephrotic) 10/2020
1	Vasculitis (Vasculitides) 01/2020

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 04/2024 - 02/2003
5	Messenger RNA (mRNA)IBA 10/2023 - 11/2011
5	Sirtuin 1IBA 01/2020 - 01/2014
4	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 04/2024 - 12/2017
4	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2023 - 01/2016
4	RNA (Ribonucleic Acid)IBA 01/2022 - 12/2018
4	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2018
3	LipidsIBA 04/2024 - 01/2019
3	Phosphotransferases (Kinase)IBA 03/2024 - 06/2015
3	CytokinesIBA 03/2024 - 01/2016
3	Protein Kinases (Protein Kinase)IBA 01/2020 - 01/2015
2	LipopolysaccharidesIBA 03/2024 - 01/2016
2	aristolochic acid I (aristolochic acid)IBA 01/2022 - 07/2017
2	puerarinIBA 01/2022 - 11/2017
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2016
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 01/2020
2	Apolipoprotein L1IBA 07/2021 - 01/2019
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2021 - 12/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 12/2018
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2020 - 01/2019
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2020 - 07/2017
2	DNA (Deoxyribonucleic Acid)IBA 12/2018 - 11/2011
2	Protein SIBA 11/2018 - 01/2018
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 04/2024
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 03/2024
1	InterferonsIBA 01/2024
1	salicylhydroxamic acid (SHAM)IBA 12/2023
1	Insulin (Novolin)FDA Link 12/2023
1	SaltsIBA 11/2023
1	vpr Gene ProductsIBA 11/2023
1	BoronIBA 01/2023
1	Proto-Oncogene Proteins c-hckIBA 01/2023
1	Viral ProteinsIBA 01/2023
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2023
1	AngiotensinogenIBA 10/2022
1	CollagenIBA 01/2022
1	Serine (L-Serine)FDA Link 01/2022
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2022
1	Sodium-Glucose Transport ProteinsIBA 01/2022
1	Leucine (L-Leucine)FDA Link 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	NF-kappa B (NF-kB)IBA 01/2022
1	ParaffinIBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 01/2022
1	Angiotensin Receptor AntagonistsIBA 01/2022
1	SYTO 13IBA 01/2022
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 07/2021
1	InterleukinsIBA 07/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	AcidsIBA 01/2021
1	RetinoidsIBA 01/2021
1	BI 2536IBA 01/2021
1	Differentiation AntigensIBA 01/2021
1	Phosphodiesterase 4 InhibitorsIBA 01/2021
1	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 01/2021
1	MAP Kinase Kinase Kinase 5IBA 01/2021
1	GS-444217IBA 01/2021
1	p38 Mitogen-Activated Protein KinasesIBA 01/2021
1	Drug CombinationsIBA 01/2020
1	empagliflozinIBA 01/2020
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2020
1	Metformin (Glucophage)FDA LinkGeneric 01/2020
1	SodiumIBA 01/2020
1	Ramipril (Altace)FDA LinkGeneric 01/2020
1	Activins (Activin)IBA 01/2020

Therapy/Procedure

15	Therapeutics 02/2024 - 01/2015
3	Nephrectomy 12/2019 - 01/2016
1	Liver Transplantation 12/2023
1	Highly Active Antiretroviral Therapy (HAART) 01/2021