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Christian Landles Selected Research

Huntington Disease (Huntington's Disease)

2/2024A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
12/2022Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
1/2021Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
1/2020TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
1/2017The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.
11/2013HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
2/2013Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
7/2012Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease.
3/2010Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
5/2007Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.
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Christian Landles Research Topics

Disease

13Huntington Disease (Huntington's Disease)
02/2024 - 10/2004
2Neurodegenerative Diseases (Neurodegenerative Disease)
11/2013 - 10/2004
1Fasciculation (Fasciculations)
01/2017
1Schizophrenia (Dementia Praecox)
01/2017
1Infertility (Sterility)
10/2011
1Heart Injuries
05/2007
1Ischemia
05/2007
1Mitochondrial Diseases (Mitochondrial Disease)
05/2007
1Necrosis
12/2003

Drug/Important Bio-Agent (IBA)

8polyglutamineIBA
02/2024 - 10/2004
6Proteins (Proteins, Gene)FDA Link
01/2021 - 10/2004
5Huntingtin ProteinIBA
02/2024 - 05/2007
1Messenger RNA (mRNA)IBA
12/2022
1Protein Isoforms (Isoforms)IBA
01/2021
1EnzymesIBA
01/2020
1Caspase 6IBA
07/2012
1Phenobarbital (Luminal)FDA Link
10/2011
1Phosphotransferases (Kinase)IBA
10/2011
1Kainic Acid (Kainate)IBA
05/2007
1Free RadicalsIBA
05/2007
1Mediator Complex Subunit 1IBA
12/2003

Therapy/Procedure

2Therapeutics
02/2024 - 12/2022