Adriaan A Lammertsma Selected Research

Epilepsy (Aura)

1/2017	Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood-Brain Barrier.
1/2017	Altered GABAA receptor density and unaltered blood-brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis.
10/2014	(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
12/2013	Radiation dose of the P-glycoprotein tracer 11C-laniquidar.
8/2013	[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.
12/2012	Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.
3/2012	[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.
1/2011	(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.
1/2009	Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography.
1/2008	Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients.

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Adriaan A Lammertsma Research Topics

Disease

44	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 09/2007
36	Neoplasms (Cancer) 03/2023 - 01/2002
20	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2017 - 10/2002
15	Dementia (Dementias) 01/2021 - 07/2010
11	Cognitive Dysfunction 01/2020 - 12/2007
11	Epilepsy (Aura) 01/2017 - 11/2005
10	Rheumatoid Arthritis 01/2020 - 01/2011
8	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2002
8	Inflammation (Inflammations) 01/2020 - 11/2006
8	Cardiomyopathies (Cardiomyopathy) 01/2017 - 03/2007
7	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 07/2011
6	Cicatrix (Scar) 01/2022 - 12/2011
6	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2020 - 02/2007
6	Neuroinflammatory Diseases 01/2020 - 03/2013
6	Arthritis (Polyarthritis) 01/2020 - 01/2012
6	Body Weight (Weight, Body) 01/2019 - 01/2008
6	Type 2 Diabetes Mellitus (MODY) 10/2013 - 04/2009
6	Insulin Resistance 10/2013 - 04/2009
5	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 04/2014
5	Amyloid Plaque 10/2018 - 11/2008
5	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 07/2010
5	Lung Neoplasms (Lung Cancer) 08/2013 - 05/2011
4	Hypoxia (Hypoxemia) 03/2023 - 01/2002
4	Multiple Sclerosis 01/2022 - 01/2018
4	Glioma (Gliomas) 01/2020 - 07/2018
4	Neoplasm Metastasis (Metastasis) 10/2018 - 04/2004
4	Schizophrenia (Dementia Praecox) 08/2016 - 11/2008
4	Synovitis 03/2014 - 11/2008
4	Familial Primary Pulmonary Hypertension 09/2013 - 11/2011
4	Head and Neck Neoplasms (Head and Neck Cancer) 03/2009 - 07/2003
3	Pulmonary Arterial Hypertension 03/2023 - 01/2018
3	Ankylosing Spondylitis 01/2023 - 01/2018
3	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 06/2020 - 01/2018
3	Hyperemia 01/2019 - 01/2014
3	Necrosis 01/2018 - 11/2007
3	Left Ventricular Dysfunction 01/2017 - 07/2006
3	Temporal Lobe Epilepsy 10/2014 - 01/2008
3	Ischemia 07/2011 - 04/2009
3	Heart Failure 04/2009 - 08/2004
3	Nervous System Diseases (Neurological Disorders) 11/2006 - 01/2005
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 07/2011
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 07/2018
2	Celiac Disease (Celiac Sprue) 01/2017 - 01/2017
2	Drug Resistant Epilepsy 01/2017 - 01/2012

Drug/Important Bio-Agent (IBA)

26	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 01/2002
22	Amyloid (Amyloid Fibrils)IBA 01/2023 - 01/2011
14	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 10/2022 - 10/2002
13	Biomarkers (Surrogate Marker)IBA 08/2021 - 11/2007
11	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2017 - 01/2005
10	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2018 - 05/2011
9	PK 11195 (PK11195)IBA 01/2016 - 11/2006
8	Proteins (Proteins, Gene)FDA Link 05/2018 - 03/2013
7	GadoliniumIBA 01/2022 - 08/2012
7	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 05/2014 - 08/2010
6	Oxygen (Dioxygen)IBA 05/2017 - 08/2006
6	Verapamil (Calan)FDA LinkGeneric 01/2017 - 01/2008
6	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 01/2015 - 04/2005
6	Docetaxel (Taxotere)FDA Link 04/2014 - 10/2010
4	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 01/2014
4	poly(ethylene glycol)-folateIBA 01/2020 - 03/2013
4	LigandsIBA 12/2017 - 03/2013
4	Flumazenil (Romazicon)FDA LinkGeneric 12/2017 - 03/2012
4	ErbB Receptors (EGF Receptor)IBA 04/2017 - 05/2011
4	Insulin (Novolin)FDA Link 12/2013 - 10/2009
4	GABA-A Receptors (GABA(A) Receptor)IBA 12/2012 - 11/2005
4	2- (1- (6- ((2- fluoroethyl)(methyl)amino)- 2- naphthyl)ethylidene)malononitrileIBA 06/2012 - 11/2008
3	Purinergic P2X7 ReceptorsIBA 01/2020 - 06/2014
3	Tyrosine (L-Tyrosine)FDA Link 01/2020 - 07/2018
3	Monoclonal AntibodiesIBA 12/2019 - 04/2006
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 03/2013
3	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 11/2018 - 03/2014
3	methylated bovine serum albumin (MBSA)IBA 01/2018 - 03/2014
3	CalciumIBA 01/2014 - 04/2012
3	ThymidineIBA 01/2013 - 11/2007
3	Carbon MonoxideIBA 12/2011 - 07/2006
3	Triglycerides (Triacylglycerol)IBA 11/2010 - 04/2009
2	MonocrotalineIBA 03/2023 - 01/2018
2	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2023 - 09/2022
2	Retinaldehyde (Retinal)IBA 08/2021 - 12/2019
2	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 01/2016
2	Amyloid beta-PeptidesIBA 01/2021 - 10/2012
2	florbetapirIBA 01/2021 - 01/2019
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2020 - 12/2017
2	Choline (Choline Chloride)IBA 06/2019 - 05/2016
2	4- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA 03/2019 - 01/2018
2	flutemetamolIBA 03/2019 - 01/2017
2	Androgen Receptors (Androgen Receptor)IBA 01/2019 - 10/2018
2	Everolimus FDA Link 01/2019 - 11/2009
2	Protein Glutamine gamma Glutamyltransferase 2IBA 05/2018 - 01/2017
2	EnzymesIBA 05/2018 - 01/2017
2	Methotrexate (Mexate)FDA LinkGeneric 01/2018 - 01/2018
2	Tyrosine Kinase InhibitorsIBA 04/2017 - 09/2014

Therapy/Procedure

33	Therapeutics 01/2021 - 04/2004
10	Drug Therapy (Chemotherapy) 12/2013 - 10/2002
7	Radiotherapy 01/2020 - 07/2003
3	Sympathectomy (Sympathectomies) 01/2020 - 07/2015
3	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2016 - 04/2010
2	Aftercare (After-Treatment) 01/2023 - 04/2008
2	Secondary Prevention 01/2021 - 10/2018
2	Castration 01/2019 - 10/2018