S Lalezari Selected Research

Hemorrhage

9/2018	BAY 94-9027, a PEGylated recombinant factor VIII, exhibits a prolonged half-life and higher area under the curve in patients with severe haemophilia A: Comprehensive pharmacokinetic assessment from clinical studies.
9/2016	Efficacy and safety of BAY 81-8973, a full-length recombinant factor VIII: results from the LEOPOLD I trial.
5/2014	Patient characteristics that influence efficacy of prophylaxis with rFVIII-FS three times per week: a subgroup analysis of the LIPLONG study.
1/2014	Correlation between endogenous VWF:Ag and PK parameters and bleeding frequency in severe haemophilia A subjects during three-times-weekly prophylaxis with rFVIII-FS.
2/2007	Trp207Gly in platelet glycoprotein Ibalpha is a novel mutation that disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome.

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S Lalezari Research Topics

Disease

7	Hemophilia A (Haemophilia) 09/2018 - 01/2006
5	Hemorrhage 09/2018 - 02/2007
2	Hyperthyroidism 07/2001 - 02/2001
1	Bernard-Soulier Syndrome (Giant Platelet Syndrome) 02/2007
1	Chronic Hepatitis C 01/2006
1	Infections 01/2006
1	Liver Diseases (Liver Disease) 01/2006
1	Virus Diseases (Viral Diseases) 01/2006
1	Thyrotoxicosis 07/2001
1	Inflammation (Inflammations) 02/2001

Drug/Important Bio-Agent (IBA)

3	sugar formulated recombinant FVIIIIBA 05/2016 - 01/2014
2	Factor VIII (Coagulation Factor VIII)IBA 09/2018 - 05/2014
2	human F8 protein FDA Link 09/2016 - 05/2016
2	Propranolol (Inderal)FDA LinkGeneric 07/2001 - 02/2001
1	BAY 94-9027IBA 09/2018
1	Sucrose (Saccharose)IBA 05/2014
1	AntigensIBA 01/2014
1	Liposomes (Liposome)IBA 09/2008
1	Glycoproteins (Glycoprotein)IBA 02/2007
1	Platelet Membrane GlycoproteinsIBA 02/2007
1	Leucine (L-Leucine)FDA Link 02/2007
1	DisulfidesIBA 02/2007
1	von Willebrand FactorIBA 02/2007
1	Blood Coagulation Factors (Coagulation Factor)IBA 01/2006
1	EnzymesIBA 01/2006
1	RNA (Ribonucleic Acid)IBA 01/2006
1	Hepatitis C AntibodiesIBA 01/2006
1	CatecholaminesIBA 07/2001
1	Adrenergic Receptors (Adrenergic Receptor)IBA 07/2001
1	C-Reactive ProteinIBA 02/2001
1	Proteins (Proteins, Gene)FDA Link 02/2001
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2001
1	Interleukin-6 (Interleukin 6)IBA 02/2001

Therapy/Procedure

1	Aftercare (After-Treatment) 02/2001