Ming-Tain Lai Selected Research

Alzheimer Disease (Alzheimer's Disease)

7/2007	Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.
1/2006	A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
7/2005	Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
5/2005	Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.
4/2005	Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
11/2002	gamma-Secretase: characterization and implication for Alzheimer disease therapy.

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Ming-Tain Lai Research Topics

Disease

12	Infections 01/2022 - 06/2009
6	Alzheimer Disease (Alzheimer's Disease) 07/2007 - 11/2002
2	Neoplasms (Cancer) 01/2023 - 01/2021
2	Headache (Headaches) 01/2020 - 01/2018
2	Nausea 01/2020 - 01/2018
2	Amyloid Plaque 01/2006 - 07/2005
1	Stomach Neoplasms (Stomach Cancer) 01/2023
1	Cardiotoxicity 10/2020
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2020
1	Paroxysmal Extreme Pain Disorder 06/2016
1	Pain (Aches) 06/2016
1	Neuralgia (Stump Neuralgia) 06/2016
1	Congenital Pain Insensitivity 06/2016
1	Parkinson Disease (Parkinson's Disease) 01/2016
1	Chronic Pain 07/2014
1	HIV Infections (HIV Infection) 01/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 11/2011

Drug/Important Bio-Agent (IBA)

9	Reverse Transcriptase InhibitorsIBA 01/2022 - 06/2009
7	doravirineIBA 01/2022 - 01/2014
6	NucleosidesIBA 01/2022 - 09/2009
4	Peptides (Polypeptides)IBA 01/2006 - 11/2002
4	Amyloid beta-PeptidesIBA 01/2006 - 04/2005
2	Globo-HIBA 01/2023 - 01/2021
2	Rilpivirine (TMC-278)IBA 10/2020 - 01/2015
2	IntegrasesIBA 10/2020 - 05/2010
2	Ritonavir (Norvir)FDA Link 01/2020 - 01/2018
2	Darunavir (Prezista)FDA Link 01/2020 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2016 - 07/2014
2	Antiviral Agents (Antivirals)IBA 01/2014 - 05/2010
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2007 - 11/2002
1	EnzymesIBA 01/2023
1	GlycosphingolipidsIBA 01/2023
1	AntigensIBA 01/2023
1	Caveolin 1IBA 01/2023
1	Immunoconjugates (Immunoconjugate)IBA 01/2023
1	FucosyltransferasesIBA 01/2023
1	GalNAc- 1- 3- (Fuc- 1- 2)Gal- 1- 3- GlcNAc- 1- 3- Gal- 1- 4- Glc- PAIBA 01/2021
1	efavirenz (Sustiva)FDA Link 10/2020
1	Ion Channels (Ion Channel)IBA 10/2020
1	Anti-Retroviral Agents (Antiretroviral Agents)IBA 10/2020
1	acivicin (AT 125)IBA 01/2018
1	NAV1.7 Voltage-Gated Sodium ChannelIBA 06/2016
1	Leucine (L-Leucine)FDA Link 01/2016
1	Green Fluorescent ProteinsIBA 01/2015
1	Protease Inhibitors (Protease Inhibitor)IBA 05/2010
1	3- (5- ((6- amino- 1H- pyrazolo(3,4- b)pyridine- 3- yl)methoxy)- 2- chlorophenoxy)- 5- chlorobenzonitrileIBA 06/2009
1	Proteins (Proteins, Gene)FDA Link 11/2002
1	Peptide Hydrolases (Proteases)FDA Link 11/2002
1	Amyloid (Amyloid Fibrils)IBA 11/2002

Therapy/Procedure

4	Therapeutics 01/2016 - 11/2002
2	Immunotherapy 01/2023 - 01/2021
2	Highly Active Antiretroviral Therapy (HAART) 11/2011 - 09/2009
1	Aftercare (After-Treatment) 01/2021