Jan P Kraus Selected Research

Cystathionine

11/2019	Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy.
12/2017	Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria.
7/2016	Thioethers as markers of hydrogen sulfide production in homocystinurias.
1/2016	Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model.
1/2013	Metabolic profiling of total homocysteine and related compounds in hyperhomocysteinemia: utility and limitations in diagnosing the cause of puzzling thrombophilia in a family.
12/2012	Conformational properties of nine purified cystathionine β-synthase mutants.
1/2012	Brain phenotype of transgenic mice overexpressing cystathionine β-synthase.

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Jan P Kraus Research Topics

Disease

33	Homocystinuria 11/2019 - 06/2002
5	Propionic Acidemia 01/2018 - 06/2002
5	Inborn Genetic Diseases (Disease, Hereditary) 07/2013 - 06/2009
2	Perinatal Death 12/2017 - 06/2002
2	Hyperhomocysteinemia 01/2013 - 06/2009
1	Osteoporosis 12/2017
1	Metabolic Diseases (Metabolic Disease) 01/2016
1	Cardiomyopathies (Cardiomyopathy) 07/2013
1	Thrombophilia 01/2013
1	Down Syndrome (Down's Syndrome) 01/2012
1	Hemorrhage 10/2010
1	Intellectual Disability (Idiocy) 10/2010
1	Fibrosis (Cirrhosis) 10/2010
1	Thromboembolism 10/2010
1	Nutrition Disorders (Nutritional Disorders) 06/2009
1	Pyridoxine-Responsive Homocystinuria 03/2007
1	Vascular Diseases (Vascular Disease) 03/2006
1	Ischemia 12/2004
1	Atherosclerosis 12/2004
1	Hepatocellular Carcinoma (Hepatoma) 11/2002
1	Starvation 07/2002
1	Ketosis 06/2002
1	Thrombosis (Thrombus) 06/2002

Drug/Important Bio-Agent (IBA)

19	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 05/2018 - 06/2002
13	HomocysteineIBA 11/2019 - 06/2002
8	Sulfur Amino AcidsIBA 01/2018 - 04/2003
7	CystathionineIBA 11/2019 - 01/2012
7	EnzymesIBA 01/2018 - 06/2002
7	Proteins (Proteins, Gene)FDA Link 01/2013 - 06/2002
6	Cysteine (L-Cysteine)FDA Link 12/2017 - 04/2003
4	S-Adenosylmethionine (Ademetionine)IBA 01/2018 - 06/2002
4	Methionine (L-Methionine)FDA Link 01/2016 - 04/2003
3	Propionyl-Coenzyme A Carboxylase (Propionyl CoA Carboxylase)IBA 01/2018 - 06/2002
3	Pyridoxine (Pyridoxin)FDA LinkGeneric 01/2013 - 04/2008
2	LigandsIBA 01/2016 - 01/2013
2	SulfurIBA 10/2013 - 01/2012
2	Amino Acids FDA Link 07/2013 - 01/2012
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2013 - 06/2009
1	lanthionineIBA 07/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2013
1	Lysine (L-Lysine)FDA Link 07/2013
1	6-propylchromone-2-carboxylic acid (PCCA)IBA 07/2013
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 07/2013
1	Alanine (L-Alanine)FDA Link 07/2013
1	AmmoniaIBA 07/2013
1	propionylcarnitineIBA 07/2013
1	S-AdenosylhomocysteineIBA 01/2013
1	VitaminsIBA 01/2013
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2013
1	Betaine (C.B.B.)FDA Link 10/2010
1	Mutant Proteins (Protein, Mutant)IBA 01/2010
1	Proteasome InhibitorsIBA 01/2010
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2009
1	homocysteine thiolactoneIBA 06/2009
1	Serum AlbuminIBA 12/2004
1	Biomarkers (Surrogate Marker)IBA 12/2004
1	Insulin (Novolin)FDA Link 11/2002
1	Messenger RNA (mRNA)IBA 11/2002
1	GlucocorticoidsIBA 11/2002
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 07/2002

Therapy/Procedure

5	Enzyme Replacement Therapy 05/2018 - 01/2016
3	Therapeutics 07/2016 - 07/2005