Ivana Krajsova Selected Research

Mitogen-Activated Protein Kinase Kinases (MEKs)

10/2023	Contribution of MEK Inhibition to BRAF/MEK Inhibitor Combination Treatment of BRAF-Mutant Melanoma: Part 2 of the Randomized, Open-Label, Phase III COLUMBUS Trial.
1/2020	Update on tolerability and overall survival in COLUMBUS: landmark analysis of a randomised phase 3 trial of encorafenib plus binimetinib vs vemurafenib or encorafenib in patients with BRAF V600-mutant melanoma.
1/2019	Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
1/2018	Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

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Ivana Krajsova Research Topics

Disease

10	Melanoma (Melanoma, Malignant) 10/2023 - 08/2005
2	Myalgia 10/2018 - 01/2018
2	Hypertension (High Blood Pressure) 10/2018 - 01/2018
2	Arthralgia (Joint Pain) 10/2018 - 01/2018
2	Neoplasms (Cancer) 01/2018 - 08/2005
1	Skin Neoplasms (Skin Cancer) 01/2020
1	Fever (Fevers) 01/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2015
1	Keratoacanthoma 01/2015

Drug/Important Bio-Agent (IBA)

8	VemurafenibIBA 10/2023 - 04/2014
5	binimetinibIBA 10/2023 - 01/2018
5	encorafenibIBA 10/2023 - 01/2018
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2023 - 01/2018
2	Creatine Kinase (Creatine Phosphokinase)IBA 10/2018 - 01/2018
2	Proto-Oncogene Proteins B-rafIBA 01/2017 - 04/2014
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	dabrafenibIBA 01/2015
1	trametinibIBA 01/2015
1	Dacarbazine (DIC)FDA LinkGeneric 04/2014
1	Imatinib Mesylate (Gleevec)FDA Link 08/2005
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2005

Therapy/Procedure

5	Therapeutics 01/2019 - 08/2005
3	Immunotherapy 01/2020 - 01/2018