Jeffrey B Kopp Selected Research

Fibrosis (Cirrhosis)

1/2024	Bile Acid Receptor Agonist Reverses Transforming Growth Factor-β1-Mediated Fibrogenesis in Human Induced Pluripotent Stem Cells-Derived Kidney Organoids.
1/2023	Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development.
11/2022	IL-18 deficiency ameliorates the progression from AKI to CKD.
11/2022	The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
1/2022	Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease.
1/2022	Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
1/2021	circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a.
12/2020	miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro.
12/2019	LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration.
1/2018	FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

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Jeffrey B Kopp Research Topics

Disease

39	Kidney Diseases (Kidney Disease) 01/2023 - 09/2002
36	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 05/2024 - 02/2006
27	Proteinuria 01/2022 - 06/2005
26	Fibrosis (Cirrhosis) 01/2024 - 03/2002
19	Chronic Renal Insufficiency 10/2023 - 09/2007
17	Diabetic Nephropathies (Diabetic Nephropathy) 01/2023 - 02/2010
16	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 08/2003
15	Albuminuria 12/2023 - 06/2005
14	Inflammation (Inflammations) 12/2023 - 01/2002
12	AIDS-Associated Nephropathy (HIV-Associated Nephropathy) 05/2024 - 08/2003
12	Infections 01/2022 - 02/2003
12	Hypertension (High Blood Pressure) 01/2022 - 04/2009
9	Wilms Tumor (Wilm's Tumor) 01/2023 - 02/2007
7	Glomerulonephritis 01/2021 - 04/2002
6	Lupus Nephritis 01/2022 - 01/2010
6	HIV Infections (HIV Infection) 01/2019 - 08/2003
5	Neoplasms (Cancer) 02/2024 - 11/2004
5	Mitochondrial Diseases (Mitochondrial Disease) 12/2023 - 01/2018
5	Insulin Resistance 10/2023 - 02/2008
5	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 09/2008
5	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2019 - 02/2006
4	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2023 - 04/2015
4	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2022 - 03/2010
4	Obesity 01/2021 - 12/2013
3	Bites and Stings (Sting) 12/2023 - 10/2021
3	Stroke (Strokes) 05/2023 - 07/2017
3	Cardiovascular Diseases (Cardiovascular Disease) 03/2023 - 01/2018
3	Type 2 Diabetes Mellitus (MODY) 01/2023 - 11/2009
3	Wounds and Injuries (Trauma) 01/2023 - 10/2007
3	Interstitial Nephritis (Tubulointerstitial Nephritis) 11/2022 - 04/2002
3	IGA Glomerulonephritis (IGA Nephropathy) 01/2022 - 06/2009
3	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 04/2002
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 04/2002
3	Disease Progression 10/2019 - 03/2002
2	COVID-19 04/2024 - 01/2022
2	Acquired Immunodeficiency Syndrome (AIDS) 11/2023 - 01/2022
2	Pregnancy Complications 11/2023 - 03/2023
2	Ischemia 10/2023 - 09/2008
2	Renal Insufficiency (Renal Failure) 05/2023 - 09/2011
2	Fatty Liver 11/2022 - 10/2017
2	Virus Diseases (Viral Diseases) 01/2022 - 01/2005
2	Nephritis 12/2021 - 08/2010

Drug/Important Bio-Agent (IBA)

30	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2003
21	Apolipoprotein L1IBA 05/2023 - 09/2010
12	Biomarkers (Surrogate Marker)IBA 11/2023 - 09/2008
9	InterferonsIBA 05/2024 - 02/2015
9	RNA (Ribonucleic Acid)IBA 05/2024 - 10/2017
9	CreatinineIBA 05/2023 - 01/2011
9	Messenger RNA (mRNA)IBA 01/2021 - 06/2009
8	CytokinesIBA 12/2023 - 01/2002
7	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2022 - 04/2004
6	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2024 - 03/2010
6	AlbuminsIBA 01/2022 - 06/2005
5	EnzymesIBA 10/2023 - 09/2004
5	CholesterolIBA 11/2022 - 07/2014
5	LipidsIBA 01/2022 - 12/2014
5	NPHS2 proteinIBA 10/2020 - 02/2006
5	AutoantibodiesIBA 12/2019 - 04/2002
5	nephrinIBA 12/2014 - 02/2007
5	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2013 - 01/2009
4	vpr Gene ProductsIBA 11/2023 - 02/2008
4	Folic Acid (Vitamin M)FDA LinkGeneric 11/2022 - 12/2011
4	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 04/2004
4	MicroRNAs (MicroRNA)IBA 01/2022 - 04/2015
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 03/2008
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 11/2010
3	Monoclonal AntibodiesIBA 04/2024 - 03/2008
3	NAD (NADH)IBA 10/2023 - 01/2018
3	Transcription Factors (Transcription Factor)IBA 10/2023 - 09/2008
3	CollagenIBA 11/2022 - 10/2020
3	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2013
3	InflammasomesIBA 01/2022 - 01/2018
3	Circular RNAIBA 01/2022 - 10/2020
3	Erythropoietin FDA Link 01/2021 - 07/2007
3	SteroidsIBA 11/2018 - 11/2007
3	Streptozocin (Streptozotocin)FDA Link 01/2018 - 11/2010
3	podocalyxinIBA 04/2012 - 03/2010
3	pirfenidoneIBA 06/2011 - 09/2007
2	Nuclear RNAIBA 05/2024 - 03/2023
2	Bile Acids and Salts (Bile Acids)IBA 01/2024 - 01/2016
2	cyclic guanosine monophosphate-adenosine monophosphateIBA 12/2023 - 01/2023
2	SaltsIBA 11/2023 - 12/2010
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 10/2023 - 01/2022
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 12/2011
2	Mitochondrial DNA (mtDNA)IBA 01/2023 - 11/2013
2	Cadherins (E-Cadherin)IBA 11/2022 - 10/2010
2	AcidsIBA 11/2022 - 11/2013
2	6-ethyl-24-norcholane-3,7,23-triol-23 sulfateIBA 11/2022 - 01/2018
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2022 - 01/2016
2	SodiumIBA 07/2022 - 01/2022
2	LigandsIBA 01/2022 - 05/2019
2	Protein Isoforms (Isoforms)IBA 01/2022 - 04/2004
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 02/2007
2	Fibronectins (Fibronectin)IBA 01/2021 - 04/2004
2	ChemokinesIBA 01/2021 - 10/2020
2	InterleukinsIBA 01/2021 - 12/2011

Therapy/Procedure

29	Therapeutics 04/2024 - 04/2002
8	Kidney Transplantation 01/2022 - 01/2003
4	Nephrectomy 01/2022 - 01/2005
3	Precision Medicine 02/2024 - 01/2018